[1]王歆烨,崔萌萌,赵刚,等.司美格鲁肽治疗2型糖尿病心血管并发症的研究进展[J].心血管病学进展,2023,(8):733.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.014]
 WANG Xinye,CUI Mengmeng,ZHAO Gang,et al.Treatment with Semaglutide in Cardiovascular Complications of?ype 2 Diabetes[J].Advances in Cardiovascular Diseases,2023,(8):733.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.014]
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司美格鲁肽治疗2型糖尿病心血管并发症的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年8期
页码:
733
栏目:
综述
出版日期:
2023-08-25

文章信息/Info

Title:
Treatment with Semaglutide in Cardiovascular Complications of?ype 2 Diabetes
作者:
王歆烨1崔萌萌1 赵刚1 王小婷2
(1.山东第一医科大学附属省立医院心血管内科,山东 济南 250021;2.山东第一医科大学附属省立医院耳鼻咽喉科(睡眠医学)
Author(s):
WANG Xinye1CUI Mengmeng1ZHAO Gang1WANG Xiaoting2
?1.Department of Cardiology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong,China2.Department of Otolaryngology (sleep medicine),Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong,China)
关键词:
2型糖尿病心血管疾病司美格鲁肽并发症
Keywords:
Type 2 diabetesCardiovascular diseaseSemaglutideComplication[]
DOI:
10.16806/j.cnki.issn.1004-3934.2023.08.014
摘要:
糖尿病的发病率随着人民生活方式的改变而逐年攀升。血糖控制不达标会导致心脏、血管、肾脏等组织器官出现各种糖尿病并发症。其中,糖尿病的心血管并发症是导致患者致残甚至死亡的重要因素。在目前临床常用的降血糖药中,胰高血糖素样肽-1受体激动剂(GLP-1RA)被证实能明显降低2型糖尿病患者心血管疾病的发病率和死亡率。司美格鲁肽是一种经过改进的新型长效GLP-1RA,不仅具有良好的控糖效应,在保护心血管方面的效果同样突出。现通过检索PubMed等多个数据库来查找司美格鲁肽应用于2型糖尿病的研究和综述,总结司美格鲁肽治疗2型糖尿病患者心血管相关并发症的研究进展,并重点关注司美格鲁肽保护心血管的具体机制。
Abstract:
The incidence of diabetes mellitus is increasing year by year with the change of people’s lifestyles. Substandard blood sugar control can lead to various diabetic complications in the heart,blood vessels,kidneys and other tissues and organs. Among them,cardiovascular complications of diabetes are an important factor leading to disability and even death of patients. Among the commonly used clinical glucose-lowering drugs,GLP-1 receptor agonists (GLP-1RA) have been shown to significantly reduce the morbidity and mortality of cardiovascular disease in patients with type 2 diabetes. Smeaglutide is a novel modified long-acting GLP-1RA with not only good glucose control effects but also outstanding cardiovascular protection. In this review,we searched several databases such as pubmed to find studies and reviews on the application of semaglutide in type 2 diabetes,summarized the research progress of semaglutide in treating cardiovascular-related complications in type 2 diabetic patients,and focused on the specific mechanism of cardiovascular protection by semaglutide.

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更新日期/Last Update: 2023-09-21