[1]薛佳欣 宫天宇 梁馨芳 王帆 张晓卉.糖尿病血管重构作用机制的研究进展[J].心血管病学进展,2023,(8):738.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.015]
 XUE Jiaxin,GONG Tianyu,LIANG Xinfang,et al.Advances in the Mechanism of Vascular Remodeling Action in Diabetes[J].Advances in Cardiovascular Diseases,2023,(8):738.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.015]
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糖尿病血管重构作用机制的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年8期
页码:
738
栏目:
综述
出版日期:
2023-08-25

文章信息/Info

Title:
Advances in the Mechanism of Vascular Remodeling Action in Diabetes
作者:
薛佳欣1 宫天宇 2 梁馨芳 1 王帆 1 张晓卉 1
(1.哈尔滨医科大学附属第一医院心血管内科,黑龙江 哈尔滨 150001;2.佳木斯大学附属第一医院,黑龙江 佳木斯 154002)
Author(s):
XUE Jiaxin 1GONG Tianyu2LIANG Xinfang1WANG Fan 1ZHANG Xiaohui 1
(1.Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin,150001,Heilongjiang,China2. Department of Cardiology,The First Affiliated Hospital of Jiamusi University,Jiamusi,154002,Heilongjiang,China)
关键词:
糖尿病血管重构平滑肌细胞表型转化
Keywords:
Diabetes mellitusVascular remodelingSmooth muscle cell phenotype transformation
DOI:
10.16806/j.cnki.issn.1004-3934.2023.08.015
摘要:
糖尿病(DM)是以血葡萄糖水平慢性升高为特征的代谢性疾病,血糖长期控制不佳引发的血管并发症会严重影响预后和患者的生活质量。血管重构是一个动态变化的过程,从一开始的适应性变化进一步发展成为DM血管并发症的病理基础。及时有效地药物干预逆转血管重构将在很大程度上避免DM血管并发症的发生。阐明DM血管重构的作用机制具有重大临床意义,现就DM血管重构涉及的相关机制做一综述,为今后靶向药物筛选和防治DM血管并发症提供新思路。
Abstract:
Diabetes mellitus (DM) is a metabolic disease characterized by a chronic increase in blood glucose levels,and vascular complications arising from poor long-term glucose control can seriously affect the prognosis and the quality of life of patients. Vascular remodeling is a dynamic change process that can further develop from the initial adaptive changes into the pathological basis of vascular complications in DM. Timely and effective pharmacological intervention to reverse vascular remodeling will largely avoid the occurrence of vascular complications in DM. It is of great clinical significance to elucidate the mechanisms involved in diabetic vascular remodeling,and this article reviews the relevant mechanisms involved in DM vascular remodeling to provide new ideas for future targeted drug screening and prevention of DM vascular complications

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更新日期/Last Update: 2023-09-21