[1]冯炜琦 陈颖慧 丁晓维 赵鹏军 于昱.多巴胺受体在心血管疾病中的作用及其分子机制研究进展[J].心血管病学进展,2022,(8):726-730.[doi:10.16806/j.cnki.issn.1004-3934.2022.08.015]
 FENG Weiqi,CHEN Yinghui,DING Xiaowei,et al.Function of Dopamine Receptors in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2022,(8):726-730.[doi:10.16806/j.cnki.issn.1004-3934.2022.08.015]
点击复制

多巴胺受体在心血管疾病中的作用及其分子机制研究进展(/HTML)
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年8期
页码:
726-730
栏目:
综述
出版日期:
2022-08-25

文章信息/Info

Title:
Function of Dopamine Receptors in Cardiovascular Diseases
作者:
冯炜琦 陈颖慧 丁晓维 赵鹏军 于昱
(上海交通大学医学院附属新华医院 心血管发育与再生医学研究所,上海 200092)
Author(s):
FENG WeiqiCHEN YinghuiDING XiaoweiZHAO PengjunYU Yu
(Institute of Cardiovascular Development and Regenerative Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200092 China)
关键词:
多巴胺受体心血管疾病高血压心肌肥厚
Keywords:
Dopamine receptorCardiovascular diseaseHypertensionCardiac hypertrophy
DOI:
10.16806/j.cnki.issn.1004-3934.2022.08.015
摘要:
目前,多巴胺及其受体在中枢神经系统中的作用被广泛报道,但其在外周尤其是在循环系统中的作用还有待研究。多巴胺受体分为D1样受体和D2样受体,哺乳动物中D1样受体包含D1和D5受体,与腺苷酸环化酶刺激有关。D2样受体包含D2、D3和D4受体,与腺苷酸环化酶抑制有关。多巴胺通过这些不同亚型受体在心血管疾病的发生和发展中发挥重要作用。现主要对多巴胺受体在心肌肥厚、心肌缺血、高血压及心律失常等心血管疾病中的作用机制的最新进展进行综述,期望对多巴胺及其受体靶点药物研发及在慢性心血管疾病中的临床应用提供理论指导。
Abstract:
At present, the role of dopamine and its receptors in the central nervous system has been widely known, but its function in the peripheral, especially the circulatory system, needs to be further studied. Dopamine receptors are divided into D1-like receptors and D2-like receptors. In mammals, D1-like receptors include D1 and D5 receptors, which are related to adenylate cyclase activation. D2-like receptors contain D2, D3 and D4 receptors and are associated with adenylyl cyclase inhibition. Dopamine involves in the occurrence and development of cardiovascular disease through these different subtypes of receptors. This review mainly summaries the latest progress in the function of dopamine receptors in cardiac hypertrophy, myocardial ischemia, hypertension and arrhythmia, hoping to provide insights into the exploration of dopamine and their receptor target drugs, as well as their application in chronic cardiovascular disease.

参考文献/References:

[1] Katugampola SD, Maguire JJ, Matthewson SR, et al. [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man [J]. Br J Pharmacol, 2001, 132(6): 1255-1260. doi:10.1038/sj.bjp.0703939.
[2] Tayebati SK, Lokhandwala MF, Amenta F. Dopamine and vascular dynamics control: present status and future perspectives [J]. Curr Neurovasc Res, 2011, 8(3): 246-257. doi:10.2174/156720211796558032.
[3] Goldberg LI. The pharmacological basis of the clinical use of dopamine [J]. Proc R Soc Med, 1977, 70 Suppl 2(Suppl 2): 7-15.
[4] Zhang MZ, Yao B, Fang X, et al. Intrarenal dopaminergic system regulates renin expression [J]. Hypertension, 2009, 53(3): 564-570. doi:10.1161/hypertensionaha.108.127035.
[5] White BH, Sidhu A. Increased oxidative stress in renal proximal tubules of the spontaneously hypertensive rat: a mechanism for defective dopamine D1A receptor/G-protein coupling [J]. J Hypertens, 1998, 16(11): 1659-1665. doi:10.1097/00004872-199816110-00013.
[6] Watanabe H, Xu J, Bengra C, et al. Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4 [J]. Kidney Int, 2002, 62(3): 790-798. doi:10.1046/j.1523-1755.2002.00525.x.
[7] Staessen JA, Kuznetsova T, Zhang H, et al. Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4 [J]. Hypertension, 2008, 51(6): 1643-1650. doi:10.1161/hypertensionaha.107.109611.
[8] Murphy MB, Murray C, Shorten GD. Fenoldopam: a selective peripheral dopamine-receptor agonist for the treatment of severe hypertension [J]. N Engl J Med, 2001, 345(21): 1548-1557. doi:10.1056/NEJMra010253.
[9] Ganguly PK, Mukherjee K, Sahai A. Renal dopamine receptors are involved in the development of cardiac hypertrophy [J]. Mol Cell Biochem, 1995, 144(1): 81-84. doi:10.1007/bf00926744.
[10] Hollon TR, Bek MJ, Lachowicz JE, et al. Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive [J]. J Neurosci, 2002, 22(24): 10801-10810. doi:10.1523/jneurosci.22-24-10801.2002.
[11] Massel D. Ibopamine and survival in severe congestive heart failure: PRIME II [J]. Lancet, 1997, 350(9071): 147. doi:10.1016/s0140-6736(05)61857-0.
[12] Yamaguchi T, Sumida TS, Nomura S, et al. Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure [J]. Nat Commun, 2020, 11(1): 4364. doi:10.1038/s41467-020-18128-x.
[13] Li Z, Yu C, Han Y, et al. Inhibitory effect of D1-like and D3 dopamine receptors on norepinephrine-induced proliferation in vascular smooth muscle cells [J]. Am J Physiol Heart Circ Physiol, 2008, 294(6): H2761-2768. doi:10.1152/ajpheart.01344.2007.
[14] Beazely MA, Watts VJ. Activation of a novel PKC isoform synergistically enhances D2L dopamine receptor-mediated sensitization of adenylate cyclase type 6 [J]. Cell Signal, 2005, 17(5): 647-653. doi:10.1016/j.cellsig.2004.10.003.
[15] Cho DI, Quan W, Oak MH, et al. Functional interaction between dopamine receptor subtypes for the regulation of c-fos expression [J]. Biochem Biophys Res Commun, 2007, 357(4): 1113-1118. doi:10.1016/j.bbrc.2007.04.066.
[16] Sarkis A, Lopez B, Roman RJ. Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension [J]. Curr Opin Nephrol Hypertens, 2004, 13(2): 205-214. doi:10.1097/00041552-200403000-00009.
[17] Li XX, Bek M, Asico LD, et al. Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice [J]. Hypertension, 2001, 38(3): 303-308. doi:10.1161/01.hyp.38.3.303.
[18] Thomas GN, Tomlinson B, Critchley JA. Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism [J]. Hypertension, 2000, 36(2): 177-182. doi:10.1161/01.hyp.36.2.177.
[19] Mejía-Rodríguez O, Alvarez-Aguilar C, Vega-Gómez HE, et al. Bromocriptine induces regression of left ventricular hypertrophy in peritoneal dialysis patients [J]. Proc West Pharmacol Soc, 2005, 48: 122-125.
[20] Li H, Shi S, Sun YH, et al. Dopamine D2 receptor stimulation inhibits angiotensin II-induced hypertrophy in cultured neonatal rat ventricular myocytes [J]. Clin Exp Pharmacol Physiol, 2009, 36(3): 312-318. doi:10.1111/j.1440-1681.2008.05064.x.
[21] Li HZ, Guo J, Gao J, et al. Role of dopamine D2 receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes [J]. J Biomed Sci, 2011, 18(1): 18. doi:10.1186/1423-0127-18-18.
[22] Wang S, Zhang F, Zhao G, et al. Mitochondrial PKC-ε deficiency promotes I/R-mediated myocardial injury via GSK3β-dependent mitochondrial permeability transition pore opening [J]. J Cell Mol Med, 2017, 21(9): 2009-2021. doi:10.1111/jcmm.13121.
[23] Han F, Konkalmatt P, Mokashi C, et al. Dopamine D(2) receptor modulates Wnt expression and control of cell proliferation [J]. Sci Rep, 2019, 9(1): 16861. doi:10.1038/s41598-019-52528-4.
[24] Zeng C, Wang D, Asico LD, et al. Aberrant D1 and D3 dopamine receptor transregulation in hypertension [J]. Hypertension, 2004, 43(3): 654-660. doi:10.1161/01.HYP.0000114601.30306.bf.
[25] Zeng C, Wang D, Yang Z, et al. Dopamine D1 receptor augmentation of D3 receptor action in rat aortic or mesenteric vascular smooth muscles [J]. Hypertension, 2004, 43(3): 673-679. doi:10.1161/01.HYP.0000118958.27649.6f.
[26] Wang X, Villar VA, Armando I, et al. Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice [J]. Pediatr Nephrol, 2008, 23(12): 2131-2146. doi:10.1007/s00467-008-0901-3.
[27] Asico LD, Ladines C, Fuchs S, et al. Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension [J]. J Clin Invest, 1998, 102(3): 493-498. doi:10.1172/jci3685.
[28] Johnson TL, Tulis DA, Keeler BE, et al. The dopamine D3 receptor knockout mouse mimics aging-related changes in autonomic function and cardiac fibrosis [J]. PLoS One, 2013, 8(8): e74116. doi:10.1371/journal.pone.0074116.
[29] Kisling A, Byrne S, Parekh RU, et al. Loss of Function in Dopamine D3 Receptor Attenuates Left Ventricular Cardiac Fibroblast Migration and Proliferation in vitro [J]. Front Cardiovasc Med, 2021, 8: 732282. doi:10.3389/fcvm.2021.732282.
[30] Sacks D, Baxter B, Campbell BCV, et al. Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke [J]. Int J Stroke, 2018, 13(6): 612-632. doi:10.1177/1747493018778713.
[31] Hussain T, Lokhandwala MF. Renal dopamine receptor function in hypertension [J]. Hypertension, 1998, 32(2): 187-197. doi:10.1161/01.hyp.32.2.187.
[32] Bek MJ, Wang X, Asico LD, et al. Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice [J]. Hypertension, 2006, 47(2): 288-295. doi:10.1161/01.Hyp.0000198427.96225.36.
[33] Armando I, Villar VA, Jose PA. Dopamine and renal function and blood pressure regulation [J]. Compr Physiol, 2011, 1(3): 1075-1117. doi:10.1002/cphy.c100032.
[34] Sunahara RK, Guan HC, O’Dowd BF, et al. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1 [J]. Nature, 1991, 350(6319): 614-619. doi:10.1038/350614a0.
[35] Allayee H, de Bruin TW, Michelle Dominguez K, et al. Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p [J]. Hypertension, 2001, 38(4): 773-778. doi:10.1161/hy1001.092617.
[36] Cooper RS, Luke A, Zhu X, et al. Genome scan among Nigerians linking blood pressure to chromosomes 2, 3, and 19 [J]. Hypertension, 2002, 40(5): 629-633. doi:10.1161/01.hyp.0000035708.02789.39.
[37] Yang Z, Asico LD, Yu P, et al. D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure [J]. Am J Physiol Regul Integr Comp Physiol, 2006, 290(1): R96-r104. doi:10.1152/ajpregu.00434.2005.
[38] Lu Q, Yang Y, Villar VA, et al. D5 dopamine receptor decreases NADPH oxidase, reactive oxygen species and blood pressure via heme oxygenase-1 [J]. Hypertens Res, 2013, 36(8): 684-690. doi:10.1038/hr.2013.9.
[39] Banday AA, Lokhandwala MF. Transcription factor Nrf2 protects renal dopamine D1 receptor function during oxidative stress [J]. Hypertension, 2013, 62(3): 512-517. doi:10.1161/hypertensionaha.113.01358.
[40] Yang Z, Asico LD, Yu P, et al. D5 dopamine receptor regulation of phospholipase D [J]. Am J Physiol Heart Circ Physiol, 2005, 288(1): H55-61. doi:10.1152/ajpheart.00627.2004.
[41] Jiang X, Shao M, Liu X, et al. Reversible Treatment of Pressure Overload-Induced Left Ventricular Hypertrophy through Drd5 Nucleic Acid Delivery Mediated by Functional Polyaminoglycoside [J]. Adv Sci (Weinh), 2021, 8(5): 2003706. doi:10.1002/advs.202003706.
[42] Brogden RN,Markham A. Fenoldopam:a review of its pharmacodynamic and pharmacokinetic properties and intravenous clinical potential in the management of hypertensive urgencies and emergencies[J]. Drugs,1997,54(4):634-650.
[43] Ozono R, O’Connell DP, Vaughan C, et al. Expression of the subtype 1A dopamine receptor in the rat heart [J]. Hypertension, 1996, 27(3 Pt 2): 693-703. doi:10.1161/01.hyp.27.3.693.
[44] Sookhai S, Wang JH, Winter D, et al. Dopamine attenuates the chemoattractant effect of interleukin-8: a novel role in the systemic inflammatory response syndrome [J]. Shock, 2000, 14(3): 295-299. doi:10.1097/00024382-200014030-00009.

相似文献/References:

[1]白春兰,张军.正五聚蛋白-3:新型心血管病炎性标志物[J].心血管病学进展,2016,(1):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
 BAI Chunlan,ZHANG Jun.Pentraxin-3: A Novel Inflammation Biomarker for Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2016,(8):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
[2]任茂佳,贺文帅,张琪,等.围绝经期对心血管疾病相关危险因素的影响[J].心血管病学进展,2019,(6):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
 REN Maojia,HE Wenshuai,ZHANG Qi,et al.Effects of Perimenopause on Cardiovascular Risk Factors[J].Advances in Cardiovascular Diseases,2019,(8):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
[3]尹琳 黄从新.JP2蛋白和心血管疾病的研究进展[J].心血管病学进展,2019,(7):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
 YIN Lin HUANG Congxin.Research Progress of JP2 Protein and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(8):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
[4]朱峰 汪汉 蔡琳.抗体与心血管疾病[J].心血管病学进展,2019,(7):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
 ZHU FengWANG HanCAI Lin.Antibodies and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(8):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
[5]邱明仙 王正龙 许官学.心肌肌球蛋白结合蛋白-C磷酸化与心血管疾病关系的研究进展[J].心血管病学进展,2019,(7):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
 QIU MingxianWANG ZhenglongXU Guanxue.Research Progress of the Relationship Between Cardiac Myosin Binding Protein-C and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(8):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
[6]姬楠楠 杨晓静 谢勇.单核细胞/高密度脂蛋白比值与心血管疾病的研究进展[J].心血管病学进展,2019,(7):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
 JI Nannan YANG Xiaojing XIE Yong.Monocyte/High-density Lipoprotein Ratio and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(8):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
[7]渠海贤 李涛 程流泉.人工智能在心脏磁共振成像中的应用进展[J].心血管病学进展,2019,(5):659.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.001]
[8]侯冬华 郝丽荣.长正五聚蛋白3在动脉粥样硬化和心血管疾病中作用研究的新进展[J].心血管病学进展,2019,(5):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
 HOU Donghua H AO Lirong.The Study of Atherosclerosis and Cardiovascular Diseases with Pentapycin 3[J].Advances in Cardiovascular Diseases,2019,(8):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
[9]张维 张恒 康品方.外泌体在心血管疾病中的研究进展[J].心血管病学进展,2019,(5):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
 Zhang WeiKang Pinfang.Exosome in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(8):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
[10]韦莹 刘书旺 李蕾 崔鸣.生长分化因子-15在心房颤动中的研究进展[J].心血管病学进展,2019,(8):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]
 WEI Ying,LIU Shuwang,LI Lei,et al.Growth Differentiation Factor-15 in Development of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2019,(8):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81974021,82170304,82070386);上海市自然科学基金面上项目(20ZR1435500)
通信作者:于昱,E-mail:yuyu@xinhuamed.com.cn
更新日期/Last Update: 2022-10-08