[1]陈忠秀,综述,饶莉,等.线粒体能量代谢异常与病理性心肌肥大的研究进展[J].心血管病学进展,2016,(3):247-250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.008]
 CHEN Zhongxiu,RAO Li.Mitochondrial Energy Metabolism and Pathological Cardiac Hypertrophy[J].Advances in Cardiovascular Diseases,2016,(3):247-250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.008]
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线粒体能量代谢异常与病理性心肌肥大的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年3期
页码:
247-250
栏目:
综述
出版日期:
2016-06-20

文章信息/Info

Title:
Mitochondrial Energy Metabolism and Pathological Cardiac Hypertrophy
作者:
陈忠秀综述饶莉审校
四川大学华西医院心内科,四川 成都 610041
Author(s):
CHEN Zhongxiu RAO Li
Department of Cardiology,West China Hospital,Sichuan University, Chengdu 610041,Sichuan,China
关键词:
线粒体 能量代谢 心肌肥大
Keywords:
Mitochondria Energy metabolism Cardiac hypertrophy
分类号:
R542.2
DOI:
10.16806/j.cnki.issn.1004-3934.2016.03.008
文献标志码:
A
摘要:
病理性心肌肥大是临床常见的适应性改变过程,伴随着能量代谢类型的转变及线粒体生物学功能的衰退,是心血管疾病发生率和病死率增高的独立危险因素。肥大心肌细胞能量代谢异常与多条信号通路异常关系密切,改善能量代谢异常有望成为逆转心肌肥大和延缓心力衰竭进程治疗的新靶点。
Abstract:
Pathological cardiac hypertrophy is a coadaptive process accompanied by metabolic profile change and mitochondrial bioenergetic decline, and is an independent predictor of higher rate of cardiovascular events and mortality. Many signaling pathways are involved in the maladaptive metabolism of hypertrophied hearts, and targeting abnormal metabolism is likely the new therapy of hypertrophic prevention and reversion.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年科学基金项目(81300169) 作者简介:陈忠秀(1988—),在读博士,主要从事心肌病的基础与临床研究。Email: czxlfb1988@163.com 通信作者:饶莉(1963—),教授,主任医师,博士生导师,博士,主要从事扩张型心肌病的基础与临床和心脏瓣膜偏心反流的定量评价研究。Email: lrlz1989@163.com
更新日期/Last Update: 2016-05-25