[1]丁娟,刘地川.心力衰竭与线粒体功能障碍的研究进展[J].心血管病学进展,2016,(1):84-86.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.022]
 DING Juan,LIU Dichuan.Research Progress of Heart Failure and Mitochondrial Dysfunction[J].Advances in Cardiovascular Diseases,2016,(1):84-86.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.022]
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心力衰竭与线粒体功能障碍的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年1期
页码:
84-86
栏目:
综述
出版日期:
2016-02-20

文章信息/Info

Title:
Research Progress of Heart Failure and Mitochondrial Dysfunction
作者:
丁娟刘地川
重庆医科大学附属第二医院心血管内科,重庆 400010
Author(s):
DING JuanLIU Dichuan
Cardiovascular Internal Medicine,The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China
关键词:
心力衰竭 能量代谢 线粒体 曲美他嗪
Keywords:
Heart failure Energy metabolism Mitochondria Trimetazidine
分类号:
R541.6
DOI:
10.16806/j.cnki.issn.1004-3934.2016.01.022
文献标志码:
A
摘要:
慢性心力衰竭的心肌细胞通常会出现能量代谢重构,造成心肌能量缺乏并且会促进心室肌的重构,加快心肌的衰竭。衰竭心肌能量代谢重构的过程主要包括高能磷酸盐代谢的改变、底物利用的转变、线粒体的功能障碍及氧化应激损伤等,而衰竭心肌发生能量代谢紊乱的关键环节是线粒体的功能障碍。
Abstract:
Myocardial energy metabolism will alter greatly in chronic heart failure, leading the energy reduction,promoting the development of myocardial remodeling, and accelerating the heart failure.Myocardial energy metabolism remodeling mainly includes changes of high-energy phosphate metabolism,substrate utilization, mitochondrial dysfunction,oxidative stress,etc. Mitochondria dysfunction play a pivotal role in myocardial metabolism disorder in chronic heart failure.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(30670870); 重庆市科委项目(CSTC2012jjA10085)
作者简介:丁娟(1990—),硕士在读,主要从事慢性心力衰竭、心肌能量代谢研究。Email:1059947885@qq.com
通信作者:刘地川(1967—),主任医师,主要从事慢性心力衰竭等心血管疾病研究。Email:ldc670220@163.com
更新日期/Last Update: 2016-02-20