[1]高凯 苏艺婉 徐望 李智 谢扬 候钦.线粒体分裂蛋白Drp1与心血管疾病研究进展[J].心血管病学进展,2019,(8):1172-1175.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.026]
 GAO Kai,SU Yiwan,XU Wang,et al.Mitochondrial Mitotic Protein Drp1 and Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(8):1172-1175.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.026]
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线粒体分裂蛋白Drp1与心血管疾病研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年8期
页码:
1172-1175
栏目:
综述
出版日期:
2019-11-25

文章信息/Info

Title:
Mitochondrial Mitotic Protein Drp1 and Cardiovascular Diseases
作者:
高凯1 苏艺婉2 徐望2 李智2 谢扬1 候钦2
(1.汕头大学医学院第二附属医院急诊科,广东 汕头 515000;2.汕头大学医学院第二附属医院心内科,广东 汕头515000)
Author(s):
GAO Kai1SU Yiwan2XU Wang2LI Zhi2XIE Yang1HOU Qin2
(Emergency Department,The Second Affiliated Hospital of Shantou University Medical College,Shantou 515000,Guangdong,China; 2.Department of Cardiology,The Second Affiliated Hospital of Shantou University School of Medicine,Shantou 515000, Guangdong,China)
关键词:
心血管疾病Drp1线粒体
Keywords:
Cardiovascular diseaseDrp1Mitochondria
DOI:
10.16806/j.cnki.issn.1004-3934.2019.08.026
摘要:
线粒体分裂蛋白Drp1是一种广泛分布于细胞质中的大型GTPase蛋白,由不同位点磷酸化激活参与不同的生理过程,维持细胞的正常功能,调节线粒体代谢,促进线粒体碎片化,激活线粒体自噬,调节线粒体外膜渗透性以及参与细胞凋亡的过程等。Drp1这一系列重要的生物学功能也参与到急性缺血再灌注损伤、糖尿病心肌病、心肌肥大和心力衰竭等多种心血管疾病的发生发展中。研究Drp1与心血管疾病的关系,或许可为治疗心血管疾病提供新的方式。现研究Drp1与心血管疾病的现状。
Abstract:
Mitochondrial fission protein Drp1 is a large GTPase proteins that is widely distributed in the cytoplasm.It is activated by different phosphorylation sites involved in different physiological processes,including maintaining cell normal function,regulating mitochondrial metabolism ,promoting the mitochondrial fragmentation ,activating the mitochondrial autophagy,adjusting the mitochondrial outer membrane permeability ,and involving in the process of cell apoptosis ,etc.The series of important biological functions of Drp1,is also involved in the occurrence and development of acute ischemia/reperfusion injury, diabetic cardiomyopathy ,myocardial hypertrophy,heart failure and other cardiovascular diseases.The study on the relationship between Drp1 and cardiovascular diseases may provide a new ways to treat cardiovascular diseases.Therefore ,this paper will study the status quo of Drp1 and cardiovascular diseases.

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更新日期/Last Update: 2020-03-02