[1]贾硕 史冬梅 张鲁辰.经皮去肾神经术在非高血压疾病治疗中的进展[J].心血管病学进展,2024,(3):216.[doi:10.16806/j.cnki.issn.1004-3934.2024.03.006]
 JIA Shuo,SHI Dongmei,ZHANG Luchen.Renal Denervation in Treatment of Non-Hypertensive Diseases[J].Advances in Cardiovascular Diseases,2024,(3):216.[doi:10.16806/j.cnki.issn.1004-3934.2024.03.006]
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经皮去肾神经术在非高血压疾病治疗中的进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年3期
页码:
216
栏目:
主题综述
出版日期:
2024-03-25

文章信息/Info

Title:
Renal Denervation in Treatment of Non-Hypertensive Diseases
作者:
贾硕 史冬梅 张鲁辰
(首都医科大学附属北京安贞医院老年心血管病中心,北京 100029 )
Author(s):
JIA ShuoSHI DongmeiZHANG Luchen
(Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029China)
关键词:
经皮去肾神经术心血管疾病阻塞性呼吸睡眠暂停代谢性疾病慢性肾脏
Keywords:
Renal denervation Cardiovascular diseaseObstructive sleep apneaMetabolic diseaseChronic kidney disease
DOI:
10.16806/j.cnki.issn.1004-3934.2024.03.006
摘要:
近年来,经皮去肾神经术(RDN)作为一种微创介入治疗,通过破坏位于肾动脉附近的交感神经来中断肾交感神经活动,阻断肾和中枢交感神经系统之间的双向信号传递,可显著且安全地降低高血压患者的血压。而肾交感神经不仅在高血压中起重要作用,同时也在心血管疾病如心律失常和心力衰竭,非心血管疾病如阻塞性睡眠呼吸暂停、代谢性疾病和慢性肾脏病等非高血压疾病中起着至关重要的作用,RDN有望成为多种疾病的上游治疗措施。现就RDN治疗非高血压疾病做一综述。
Abstract:
In recent years,renal denervation(RDN),as a minimally invasive intervention treatment,interrupts renal sympathetic nerve activity by disru pting the sympathetic nerve located near the renal artery,blocking bidirectional signal transmission between the kidney and central sympathetic nervous system,and significantly and safely reducing blood pressure in hypertensive patients. The renal sympathetic nerve not only plays an important role in hypertension,but also plays a crucial role in cardiovascular diseases such as arrhythmia and heart failure,non cardiovascular diseases such as obstructive sleep apnea,metabolic diseases and chronic kidney disease. RDN is expected to become an upstream treatment for various diseases. This article provides a review of RDN for the treatment of non-hypertensive diseases.通信作者:史冬梅,E-mail:18910778615@163.com

参考文献/References:

[1].DeLalio LJ,Sved AF,Stocker SD. Sympathetic nervous system contributions to hypertension:updates and therapeutic relevance[J]. Can J Cardiol,2020,36(5):712-720.
[2].Grassi G,Mark A,Esler M. The sympathetic nervous system alterations in human hypertension[J]. Circ Res,2015,116(6):976-990.
[3].Kasprzycki K,Petkow-Dimitrow P,Krawczyk-O?óg A,et al. Anatomic variations of renal arteries as an important factor in the effectiveness of renal denervation in resistant hypertension[J].?J Cardiovasc Dev Dis,2023,10(9):371.
[4].Krum H,Schlaich M,Whitbourn R,et al. Catheter-based renal sympathetic denervation for resistant hypertension:a multicentre safety and proof-of-principle cohort study[J]. Lancet,2009,373(9671):1275-1281.
[5].Hoogerwaard AF,Elvan A. Is renal denervation still a treatment option in cardiovascular disease?[J]. Trends Cardiovasc Med,2020,30(4):189-195.
[6].Johns EJ,Kopp UC,DiBona GF. Neural control of renal function[J]. Compr Physiol,2011,1(2):731-767.
[7].王辉,段大为,刘迎午. 经皮去肾交感神经消融术治疗顽固性高血压的研究进展[J]. 生物医学工程与临床,2021,25(1):117-121.
[8].Sobotka PA,Mahfoud F,Schlaich MP,et al. Sympatho-renal axis in chronic disease[J]. Clin Res Cardiol,2011,100(12):1049-1057.
[9].Drexel T,Bertog SC,Vaskelyte L,et al. Renal denervation[J]. Anadolu Kardiyol Derg,2014,14(2):186-191.
[10].Floras JS. Sympathetic nervous system activation in human heart failure:clinical implications of an updated model[J]. J Am Coll Cardiol,2009,54(5):375-385.
[11].Arimoto T,Tada H,Igarashi M,et al. High washout rate of iodine-123-metaiodobenzylguanidine imaging predicts the outcome of catheter ablation of atrial fibrillation[J]. J Cardiovasc Electrophysiol,2011,22(12):1297-1304.
[12].Esler M,Lambert G,Jennings G. Regional norepinephrine turnover in human hypertension[J]. Clin Exp Hypertens A,1989,11(suppl 1):75-89.
[13].Kario K,Hettrick DA,Prejbisz A,et al. Obstructive sleep apnea-induced neurogenic nocturnal hypertension:a potential role of renal denervation?[J]. Hypertension,2021,77(4):1047-1060.
[14].Mancia G,Bousquet P,Elghozi JL,et al. The sympathetic nervous system and the metabolic syndrome[J]. J Hypertens,2007,25(5):909-920.
[15].Hausberg M,Grassi G. Mechanisms of sympathetic overactivity in patients with chronic renal failure:a role for chemoreflex activation?[J]. J Hypertens,2007,25(1):47-49.
[16].Esler MD,Krum H,Sobotka PA,et al. Renal sympathetic denervation in patients with treatment-resistant hypertension(The Symplicity HTN-2 Trial):a randomised controlled trial[J]. Lancet,2010,376(9756):1903-1909.
[17].Parati G,Esler M. The human sympathetic nervous system:its relevance in hypertension and heart failure[J]. Eur Heart J,2012,33(9):1058-1066.
[18].Yu L,Huang B,Wang Z,et al. Impacts of renal sympathetic activation on atrial fibrillation:the potential role of the autonomic cross talk between kidney and heart[J]. J Am Heart Assoc,2017,6(3):e004716.
[19].Goyal A,Jain H,Verma A,et al. The role of renal denervation in cardiology and beyond:an updated comprehensive review and future directives[J]. Curr Probl Cardiol,2024,49(2):102196.
[20].Cao F,Gao YX,Wang Y. Research advance of renin-angiotensin-aldosterone system in atrial fibrillation and atrial structural remodeling[J]. Adv Cardiovasc Dis,2018,39(4):528-531.
[21].Ukena C,Bauer A,Mahfoud F,et al. Renal sympathetic denervation for treatment of electrical storm:first-in-man experience[J]. Clin Res Cardiol,2012,101(1):63-67.
[22].Pokushalov E,Romanov A,Corbucci G,et al. A randomized comparison of pulmonary vein isolation with versus without concomitant renal artery denervation in patients with refractory symptomatic atrial fibrillation and resistant hypertension[J]. J Am Coll Cardiol,2012,60(13):1163-1170.
[23].Vollmann D, Sossalla S, Schroeter M R, et al. Renal artery ablation instead of pulmonary vein ablation in a hypertensive patient with symptomatic, drug-resistant, persistent atrial fibrillation[J]. Clinical Research in Cardiology, 2013: 1-4.
[24].余静. 肾动脉交感神经消融有望成为一种新的治疗心力衰竭的方法[J]. 兰州大学学报(医学版),2022,48(2):1-3.
[25].张艳,包明威. 干预交感神经过度激活治疗心力衰竭的研究进展[J]. 医学研究杂志,2022,51(12):14-17,21.
[26].Sharp TE 3rd,Lefer DJ. Renal denervation to treat heart failure[J]. Annu Rev Physiol,2021,83:39-58.
[27].McDonagh TA,Metra M,Adamo M,et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure:developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology(ESC). With the special contribution of the Heart Failure Association(HFA) of the ESC[J]. Eur J Heart Fail,2022,24(1):4-131.
[28].Polhemus DJ,Trivedi RK,Gao J,et al. Renal sympathetic denervation protects the failing heart via inhibition of neprilysin activity in the kidney[J]. J Am Coll Cardiol,2017,70(17):2139-2153.
[29].Jaén-?guila F,Vargas-Hitos JA,Mediavilla-García JD. Implications of renal denervation therapy in patients with sleep apnea[J]. Int J Hypertens,2015,2015:408574.
[30].Davies JE,Manisty CH,Petraco R,et al. First-in-man safety evaluation of renal denervation for chronic systolic heart failure:primary outcome from REACH-Pilot study[J]. Int J Cardiol,2013,162(3):189-192.
[31].国家卫生健康委高血压诊疗研究重点实验室学术委员会,国家卫生健康委高血压诊疗研究重点实验室,新疆维吾尔自治区人民医院高血压中心. 2023阻塞性睡眠呼吸暂停相关性高血压临床诊断和治疗专家共识[J]. 中华高血压杂志,2023,31(12):1142-1155.
[32].Shantha GP,Pancholy SB. Effect of renal sympathetic denervation on apnea-hypopnea index in patients with obstructive sleep apnea:a systematic review and meta-analysis[J]. Sleep Breath,2015,19(1):29-34.
[33].Flaa A,Aksnes TA,Kjeldsen SE,et al. Increased sympathetic reactivity may predict insulin resistance:an 18-year follow-up study[J]. Metabolism,2008,57(10):1422-1427.
[34].Oliveira TL,Lincevicius GS,Shimoura CG,et al. Effects of renal denervation on cardiovascular,metabolic and renal functions in streptozotocin-induced diabetic rats[J]. Life Sci,2021,278:119534.
[35].Santulli G,Trimarco B,Iaccarino G. G-protein-coupled receptor kinase 2 and hypertension:molecular insights and pathophysiological mechanisms[J]. High Blood Press Cardiovasc Prev,2013,20(1):5-12.
[36].Mahfoud F,Schlaich M,Kindermann I,et al. Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension:a pilot study[J]. Circulation,2011,123(18):1940-1946.
[37].Manukyan M,Falkovskaya A,Mordovin V,et al. Favorable effect of renal denervation on elevated renal vascular resistance in patients with resistant hypertension and type 2 diabetes mellitus[J]. Front Cardiovasc Med,2022,9:1010546.
[38].Veiga AC,Milanez MIO,Ferreira GR,et al. Selective afferent renal denervation mitigates renal and splanchnic sympathetic nerve overactivity and renal function in chronic kidney disease-induced hypertension[J]. J Hypertens,2020,38(4):765-773.
[39].Lv J,Ehteshami P,Sarnak MJ,et al. Effects of intensive blood pressure lowering on the progression of chronic kidney disease:a systematic review and meta-analysis[J]. CMAJ,2013,185(11):949-957.
[40].Hering D,Marusic P,Duval J,et al. Effect of renal denervation on kidney function in patients with chronic kidney disease[J]. Int J Cardiol,2017,232:93-97.
[41].Solbu MD,Miroslawska A,Norvik JV,et al. Kidney function and markers of renal damage after renal denervation. Does method of measurement matter? The Reshape CV-Risk Study[J]. J Clin Hypertens(Greenwich),2021,23(5):954-962.
[42].Liu S,Bian R,Qian Y,et al. Catheter-based renal denervation in Chinese patients with chronic kidney disease and uncontrolled hypertension[J]. J Clin Hypertens(Greenwich),2023,25(1):71-77.

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备注/Memo

备注/Memo:
收稿日期:2024-01-14
更新日期/Last Update: 2024-04-26