[1]谢朋昌 侯经远 钟志雄.泛免疫炎症值在心血管疾病中的研究进展[J].心血管病学进展,2025,(4):341.[doi:10.16806/j.cnki.issn.1004-3934.2025.04.013]
 XIE Pengchang,HOU Jingyuan,ZHONG Zhixiong.Pan-Immune-Inflammation Value and C ardiovascular Diseases[J].Advances in Cardiovascular Diseases,2025,(4):341.[doi:10.16806/j.cnki.issn.1004-3934.2025.04.013]
点击复制

泛免疫炎症值在心血管疾病中的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年4期
页码:
341
栏目:
综述
出版日期:
2025-04-25

文章信息/Info

Title:
Pan-Immune-Inflammation Value and C ardiovascular Diseases
作者:
谢朋昌1 侯经远 2 钟志雄 12
(1.广东医科大学,广东 湛江 524023 ;2.梅州市人民医院(梅州市医学科学院)
Author(s):
XIE Pengchang1HOU Jingyuan2ZHONG Zhixiong12
(1.Guangdong Medical University,Zhanjiang 524023, Guangdong,China;2.Meizhou People’s Hospital(Meizhou Academy of Medical Sciences),Meizhou 514031,Guangdong,China)
关键词:
泛免疫炎症值心血管疾病生物标志物诊断预后
Keywords:
Pan-immune-inflammation valueCardiovascular diseasesBiomarkersDiagnosisPrognosis
DOI:
10.16806/j.cnki.issn.1004-3934.2025.04.013
摘要:
心血管疾病因其日益攀升的发病率和致死率,已经成为全球范围内的重大公共卫生问题。免疫和炎症反应在心血管疾病的病理进程中发挥着关键作用。近年来,随着免疫炎症生物标志物的不断发现,其在临床实践和科学研究中的应用引起了广泛关注。不断积累的证据表明,泛免疫炎症值在心血管疾病、肿瘤以及脑血管疾病等多个领域中,展现出了显著的诊断价值和对预后风险评估潜力。现通过系统探讨PIV在心血管疾病研究中的应用现状及其在临床实践中的潜在意义,旨在为后续的研究提供参考。
Abstract:
Cardiovascular diseases (CVD) have become a major public health problem worldwide due to their increasing morbidity and mortality. In the occurrence and development of CVD,immune and inflammatory responses play a key role in the pathological process. In recent years,with the discovery of immunoinflammatory biomarkers,their application in clinical practice and scientific research has attracted wide attention. Accumulating evidence indicates that the pan-immune-inflammation value (PIV) demonstrates significant diagnostic value and potential for risk assessment of prognosis in CVD,oncology,and cerebrovascular diseases. This review systematically explores the current application of PIV in cardiovascular disease research and its potential significance in clinical practice,aiming to provide a reference for subsequent studies

参考文献/References:

[1] 刘明波,何新叶,杨晓红,等.《中国心血管健康与疾病报告2023》要点解读[J]. 中国全科医学,2024,29(04):1-19.
[2] Pizzolo F,Castagna A,Olivieri O,et al. Basophil blood cell count is associated with enhanced factor Ⅱ plasma coagulant activity and increased risk of mortality in patients with stable coronary artery disease:not only neutrophils as prognostic marker in ischemic heart disease[J]. J Am Heart Assoc,2021,10(5):e018243.
[3] Fucà G,Guarini V,Antoniotti C,et al. The pan-immune-inflammation value is a new prognostic biomarker in metastatic colorectal cancer:results from a pooled-analysis of the Valentino and TRIBE first-line trials[J]. Br J Cancer,2020,123(3):403-409.
[4] Qi X,Qiao B,Song T,et al. Clinical utility of the pan-immune-inflammation value in breast cancer patients[J]. Front Oncol,2023,13:1223786.
[5] Baptista EA,Queiroz BL. Spatial analysis of cardiovascular mortality and associated factors around the world[J]. BMC Public Health,2022,22(1):1556.
[6] Maleki M,Tajlil A,Separham A,et al. Association of neutrophil to lymphocyte ratio(NLR) with angiographic SYNTAX score in patients with non-ST-Segment elevation acute coronary syndrome(NSTE-ACS)[J]. J Cardiovasc Thorac Res,2021,13(3):216-221.
[7] Li H,Meng S,Chen W,et al. Comparison of different systemic inflammatory markers in predicting clinical outcomes with syntax score in patients with non-ST segment elevation myocardial infarction:a retrospective study[J]. Int J Gen Med,2023,16:2595-2607.
[8] Cetinkaya Z ,Kelesoglu S,Tuncay A,et al. The role of pan-immune-inflammation value in determining the severity of coronary artery disease in NSTEMI patients [J]. J Clin Med,2024,13(5):1295.
[9] Peng A,Zhang B,Wang S,et al. Comparison of the value of various complex indexes of blood cell types and lipid levels in coronary heart disease[J]. Front Cardiovasc Med,2023,10:1284491.
[10] Demirtola A?,Erd?l MA,Mammadli A,et al. Predicting coronary artery severity in patients undergoing coronary computed tomographic angiography:insights from pan-immune inflammation value and atherogenic index of plasma[J]. Nutr Metab Cardiovasc Dis,2024,34(10):2289-2297.
[11] Le A,Peng H,Golinsky D,et al. What causes premature coronary artery disease?[J] Curr Atheroscler Rep,2024,26(6):189-203.
[12] 徐敏敏. 泛免疫炎症值与早发冠心病及其冠脉病变严重程度的相关性分析[D]. 大连医科大学,2023,000437.
[13] Sagris M,Antonopoulos AS,Theofilis P,et al. Risk factors profile of young and older patients with myocardial infarction[J]. Cardiovasc Res,2022,118(10):2281-2292.
[14] 马春亚,林杰,丁仁. 泛免疫炎症指数与急性ST段抬高型心肌梗死患者介入术后不良预后的关系[J]. 心肺血管病杂志,2024,43(03):228-232.
[15] Liu Y,Liu J,Liu L,et al. Association of systemic inflammatory response index and pan-immune-inflammation-value with long-term adverse cardiovascular events in ST-segment elevation myocardial infarction patients after primary percutaneous coronary intervention [J]. J Inflamm Res,2023,16:3437-3454.
[16] Yang L,Guo J,Chen M,et al. Pan-immune-inflammatory value is superior to other inflammatory indicators in predicting inpatient major adverse cardiovascular events and severe coronary artery stenosis after percutaneous coronary intervention in STEMI patients[J]. Rev Cardiovasc Med,2024,25(8):294.
[17] Murat B,Murat S,Ozgeyik M,et al. Comparison of pan‐immune‐inflammation value with other inflammation markers of long‐term survival after ST-segment elevation myocardial infarction[J]. Eur J Clin Invest,2023,53(1):e13872.
[18] Jiang H,Li D,Xu T,et al. Systemic immune-inflammation index predicts contrast-induced acute kidney injury in patients undergoing coronary angiography:a cross-sectional study[J]. Front Med (Lausanne),2022,9:841601.
[19] Chillo P,Malaja NW,Kisenge P. Magnitude and associated factors of contrast induced nephropathy among patients undergoing coronary angiography and interventions at a cardiac referral hospital in Tanzania-a cross-sectional study[J]. Pan Afr Med J,2021,38:311.
[20] Akkaya S ,Cakmak U. Association between pan-immune-inflammation value and contrast-induced nephropathy with coronary angiography[J]. Medicina ( Kaunas),2024,60(6):1012.
[21] Cetinkaya Z,Kelesoglu S. The role of pan-immune-inflammation value in predicting contrast-induced nephropathy development in patients undergoing percutaneous coronary intervention due to NSTEMI[J]. Angiology,2023:33197231211107. DOI:10.1177/00033197231211107.
[22] Kurtul A,Gok M. Preinterventional pan-immune-inflammation value as a tool to predict postcontrast acute kidney injury among acute coronary syndrome patients implanted drug-eluting stents:a retrospective observational study[J]. Scand J Clin Lab Invest,2024,84(2):97-103.
[23] ?en F,Kurtul A,Bekler ?. Pan-immune-inflammation value is independently correlated to impaired coronary flow after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction[J]. Am J Cardiol,2024,211:153-159.
[24] Kaplangoray M,Toprak K,Deveci E,et al. Could pan-immune-inflammation value be a marker for the diagnosis of coronary slow flow phenomenon ?[J]. Cardiovasc Toxicol,2024,24(5):519-526.
[25] Bayramo?lu A,Hidayet ?. Association between pan-immune-inflammation value and no-reflow in patients with ST elevation myocardial infarction undergoing percutaneous coronary intervention[J]. Scand J Clin Lab Invest,2023,83(6):384-389.
[26] Kelesoglu S,Yilmaz Y,Elc?k D,et al. Systemic immune inflammation index:a novel predictor for coronary collateral circulation[J]. Perfusion,2022,37(6):605-612.
[27] Yilmaz Y,Kelesoglu S. The importance of pan-immune inflammation value(PIV) in predicting coronary collateral circulation in stable coronary artery patients[J]. Angiology,2024:33197241258529. DOI:10.1177/00033197241258529.
[28] Zhang B,Li Y,Peng A,et al. Association between the pan-immune-inflammation value and coronary collateral circulation in chronic total coronary occlusive patients[J]. BMC Cardiovasc Disord,2024,24(1):458.
[29] Onnis C,Virmani R,Kawai K,et al. Coronary artery calcification:current concepts and clinical implications[J]. Circulation,2024,149(3):251-266.
[30] Jin C,Li X,Luo Y,et al. Associations between pan-immune-inflammation value and abdominal aortic calcification:a cross-sectional study[J]. Front Immunol,2024,15:1370516.
[31] Adamo L,Rocha-Resende C,Prabhu SD,et al. Reappraising the role of inflammation in heart failure[J]. Nat Rev Cardiol,2020,17(5):269-285.
[32] Inan D,Erdogan A,Pay L,et al. The prognostic impact of inflammation in patients with decompensated acute heart failure,as assessed using the pan-immune inflammation value (PIV)[J]. Scand J Clin Lab Invest,2023,83(6):371-378.
[33] Murat B,Murat S,Alt?nbas ME,et al. Association of pan immune-inflammation value with long term outcomes of acute decompensated heart failure[J]. Arq Bras Cardiol,2024,121(6):e20230817.
[34] Madhur MS,Elijovich F,Alexander MR,et al. Hypertension:do inflammation and immunity hold the key to solving this epidemic?[J]. Circ Res,2021,128(7):908-933.
[35] Chen J,Luo C,Tan D,et al. J-shaped associations of pan-immune-inflammation value and systemic inflammation response index with stroke among American adults with hypertension:evidence from NHANES 1999–2020[J]. Front Neurol,2024,15:1417863.
[36] Sivri F,Güng?r H,?okp?nar S,et al. Value of preoperative platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios in predicting postoperative atrial fibrillation in patients undergoing lung resection[J]. J Tehran Heart Cent,2022,17(4):236-242.
[37] Eyiol A. The relationship of pan-immune-inflammation value(PIV) and HALP score with prognosis in patients with atrial fibrillation[J]. Medicine(Baltimore),2024,103(36):e39643.
[38] Gao S ,Zhang K,Zhou C,et al. HSPB6 deficiency promotes the development of aortic dissection and rupture[J]. Lab Invest,2024,104(3):100326.
[39] Yu X,Chen Y,Peng Y,et al. The pan-immune inflammation value at admission predicts postoperative in-hospital mortality in patients with acute type A aortic dissection[J]. J Inflamm Res,2024,17:5223-5234.

相似文献/References:

[1]白春兰,张军.正五聚蛋白-3:新型心血管病炎性标志物[J].心血管病学进展,2016,(1):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
 BAI Chunlan,ZHANG Jun.Pentraxin-3: A Novel Inflammation Biomarker for Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2016,(4):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
[2]任茂佳,贺文帅,张琪,等.围绝经期对心血管疾病相关危险因素的影响[J].心血管病学进展,2019,(6):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
 REN Maojia,HE Wenshuai,ZHANG Qi,et al.Effects of Perimenopause on Cardiovascular Risk Factors[J].Advances in Cardiovascular Diseases,2019,(4):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
[3]尹琳 黄从新.JP2蛋白和心血管疾病的研究进展[J].心血管病学进展,2019,(7):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
 YIN Lin HUANG Congxin.Research Progress of JP2 Protein and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(4):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
[4]朱峰 汪汉 蔡琳.抗体与心血管疾病[J].心血管病学进展,2019,(7):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
 ZHU FengWANG HanCAI Lin.Antibodies and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(4):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
[5]邱明仙 王正龙 许官学.心肌肌球蛋白结合蛋白-C磷酸化与心血管疾病关系的研究进展[J].心血管病学进展,2019,(7):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
 QIU MingxianWANG ZhenglongXU Guanxue.Research Progress of the Relationship Between Cardiac Myosin Binding Protein-C and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(4):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
[6]姬楠楠 杨晓静 谢勇.单核细胞/高密度脂蛋白比值与心血管疾病的研究进展[J].心血管病学进展,2019,(7):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
 JI Nannan YANG Xiaojing XIE Yong.Monocyte/High-density Lipoprotein Ratio and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(4):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
[7]渠海贤 李涛 程流泉.人工智能在心脏磁共振成像中的应用进展[J].心血管病学进展,2019,(5):659.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.001]
[8]侯冬华 郝丽荣.长正五聚蛋白3在动脉粥样硬化和心血管疾病中作用研究的新进展[J].心血管病学进展,2019,(5):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
 HOU Donghua H AO Lirong.The Study of Atherosclerosis and Cardiovascular Diseases with Pentapycin 3[J].Advances in Cardiovascular Diseases,2019,(4):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
[9]张维 张恒 康品方.外泌体在心血管疾病中的研究进展[J].心血管病学进展,2019,(5):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
 Zhang WeiKang Pinfang.Exosome in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(4):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
[10]韦莹 刘书旺 李蕾 崔鸣.生长分化因子-15在心房颤动中的研究进展[J].心血管病学进展,2019,(8):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]
 WEI Ying,LIU Shuwang,LI Lei,et al.Growth Differentiation Factor-15 in Development of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2019,(4):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]

更新日期/Last Update: 2025-05-16