[1]唐春容 乔卫龙 夏茏 罗琳 罗义钢.哮喘与心血管疾病共病的研究进展[J].心血管病学进展,2025,(3):225.[doi:10.16806/j.cnki.issn.1004-3934.2025.03.008]
 TANG Chunrong,QIAO Weilong,XIA long,et al.Advances in Comorbidity of Asthma and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2025,(3):225.[doi:10.16806/j.cnki.issn.1004-3934.2025.03.008]
点击复制

哮喘与心血管疾病共病的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年3期
页码:
225
栏目:
综述
出版日期:
2025-03-25

文章信息/Info

Title:
Advances in Comorbidity of Asthma and Cardiovascular Disease
作者:
唐春容1 乔卫龙1 夏茏2 罗琳1 罗义钢1
(1. 金堂县第二人民医院/成都市第三人民医院淮州新城医院,四川 成都610404 ;2. 成都市第三人民医院,四川 成都610031)
Author(s):
TANG Chunrong1QIAO Weilong1XIA long2LUO Lin1LUO Yigang1
(1.Jintang Second Peoples Hospital/The Third Peoples Hospital of Chengdu,Huaizhou Hospital,Chengdu 610404,Sichuan,China; 2.The Third Peoples Hospital of Chengdu,Chengdu 610031,Sichuan,China)
关键词:
哮喘心血管疾病共病机制
Keywords:
AsthmaCardiovascular diseaseComorbidityMechanism
DOI:
10.16806/j.cnki.issn.1004-3934.2025.03.008
摘要:
流行病学证据显示哮喘与多种心血管事件相关,包括动脉粥样硬化性心脏病、心房颤动、心力衰竭等。二者之间的共病机制可能涉及全身性炎症、氧化应激、自主神经功能紊乱以及遗传因素。目前,治疗哮喘与心血管疾病共病尚无特效药物,但一些药物如长效β2受体激动剂、抗胆碱能药、tezepelumab等可能不增加心血管风险,而罗氟司特、度普利尤单抗等药物可能同时对哮喘和心血管疾病有益。现阐述哮喘与心血管疾病的共病风险、机制以及可能的治疗药物,为临床治疗提供一定的思路。
Abstract:
Epidemiological evidence indicates that asthma is associated with various cardiovascular events,including atherosclerotic heart disease,atrial fibrillation,heart failure,among others. The potential mechanisms between the two may involve systemic inflammation,oxidative stress,autonomic nervous dysfunction,and genetic factors. Currently,there is no specific drug for the treatment of asthma comorbid with cardiovascular disease,but some medications such as long-acting β2-agonist,anticholinergic drug,and tezepelumab may not increase cardiovascular risk,while drugs like roflumilast and dupilumab may be beneficial for both asthma and cardiovascular disease. The risk,mechanism and possible therapeutic drugs of comorbidity between asthma and cardiovascular disease are expounded in order to provide some ideas for clinical medical treatment

参考文献/References:

[1] Roth GA,Mensah GA,Johnson CO,et al. Global burden of cardiovascular diseases and risk factors,1990-2019:update from the GBD 2019 study[J]. J Am Coll Cardiol,2020,76(25):2982-3021.

[2] Dadhania K,Ghosh B,Thota A,et al. Global,regional,and national trends in cardiovascular disease burden and risk factors in individuals under 20 from 1990 to 2019:insights from the GBD 2019 study[J]. J Am Coll Cardiol,2024,83(13):2321.

[3] 刘明波,王增武,樊静,等. 《中国心血管健康与疾病报告2023》要点解读[J]. 中国心血管病杂志,2024,22(7) :577-593.

[4] Mohammadnia N,Opstal TSJ,El Messaoudi S,et al. An update on inflammation in atherosclerosis:how to effectively treat residual risk[J]. Clin Ther,2023,45(11):1055-1059.

[5] Yang CH,Lv JJ,Li XY,et al. Global burden of asthma in young adults in 204 countries and territories,1990-2019:systematic analysis of the global burden of disease study 2019[J]. Prev Med Rep,2024,37:102531.

[6] Zhang B,Li ZF,An ZY,et al. Association between asthma and all-cause mortality and cardiovascular disease morbidity and mortality:a meta-analysis of cohort studies [J]. Front Cardiovasc Med,2022,9:861798.

[7] Hua ML,Li L,Diao LL. Bronchial asthma and risk of 4 specific cardiovascular diseases and cardiovascular mortality:a meta-analysis of cohort studies[J]. Eur Rev Med Pharmaco,2022,26(14):5081-5091.

[8] Picado C,Pernigotti A,Arismendi E. Asthma:a new cardiovascular risk factor? [J]Arch Bronconeumol,2019,55(7) :353-354.

[9] Wee JH,Park MW,Min C,et al. Association between asthma and cardiovascular disease[J]. Eur J Clin Invest,2021,51(3):e13396.

[10] Choi HG,Kwon MJ,Kim JH,et al. Association between asthma and cardiovascular diseases:a longitudinal follow-up study using a national health screening cohort[J]. World Allergy Organ J ,2024,17(6):100907.

[11] Naharro-González S,Lorente-Sorolla C,Rodrigo-Mu?oz JM,et al. Moderate-high blood eosinophilia is associated with increased hospitalization and other asthma comorbidities[J]. Biomolecules,2024,14(1):126.

[12] Chen H,Chen W,Zheng L. Genetic liability to asthma and risk of cardiovascular diseases:a Mendelian randomization study[J]. Front Genet,2022,13:879468.

[13] Valencia-Hernández CA,Del Greco MF,Sundaram V,et al. Asthma and incident coronary heart disease:an observational and Mendelian randomisation study[J]. Eur Respir J,2023,62(5):2301788.

[14] Aggarwal K,Bansal V,Mahmood R,et al. Asthma and cardiovascular diseases:uncovering common ground in risk factors and pathogenesis[J]. Cardiol Rev,2023 Aug 18. DOI:10.1097/CRD.0000000000000600. Online ahead of print.

[15] Scott HA,Ng SH,McLoughlin RF,et al. Effect of obesity on airway and systemic inflammation in adults with asthma:a systematic review and meta-analysis[J]. Thorax,2023,78 (10):957-965.

[16] Kim Y,Moonie S,Yoo JW,et al. Class Ⅲ obesity as a risk factor for persistent asthma[J]. Respir Care,2024 Aug 6:respcare.11934. DOI:10.4187/respcare.11934. Epub ahead of print.

[17] Karamzad N,Izadi N,Sanaie S,et al. Asthma and metabolic syndrome:a comprehensive systematic review and meta-analysis of observational studies[J]. J Cardiovasc Thorac,2020,12(2) :120-128.

[18] de Boer GM,Tramper-Stranders GA,Houweling L,et al. Adult but not childhood onset asthma is associated with the metabolic syndrome,independent from body mass index[J]. Resp Med,2021,188:106603.

[19] Christiansen SC,Schatz M,Yang SJ,et al. Hypertension and asthma:a comorbid relationship[J]. J Allergy Clin Immunol Pract,2016,4(1):76-81.

[20] Zolotareva O,Saik OV,K?nigs C,et al. Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects[J]. Sci Rep,2019,9(1):16302.

[21] Foer D,Beeler PE,Cui J,et al. Asthma exacerbations in patients with type 2 diabetes and asthma on glucagon-like peptide-1 receptor agonists[J]. Am J Resp Crit Care,2021,203(7):831-840.

[22]Wen L,Zhong W,Chai Y,et al. Association of metformin use with asthma exacerbation in patients with concurrent asthma and diabetes:a systematic review and meta-analysis of observational studies[J]. Can Respir J,2020:9705604.

[23] Tattersall MC. Asthma as a systemic disease:cardiovascular effects associated with asthma. Adv Exp Med Biol,2023,1426:77-100.

[24] de Caterina,R,Zampolli,A. From asthma to atherosclerosis--5-lipoxygenase,leukotrienes,and inflammation[J]. New Engl J Med,2004,350(1):4-7.

[25] Lewis MJ,Short AL,Lewis KE. Autonomic nervous system control of the cardiovascular and respiratory systems in asthma[J]. Resp Med,2006,100(10):1688-1705.

[26] Mayor S. Adult onset asthma may increase risk of heart disease and stroke[J]. BMJ,2016:i4685.

[27] Zhou Y,Liang ZS,Jin Y,et al. Shared genetic architecture and causal relationship between asthma and cardiovascular diseases:a large-scale cross-trait analysis[J]. Front Genet,2021,12:775591.

[28] Whatling C,McPheat W,Hersl?f M. The potential link between atherosclerosis and the 5-lipoxygenase pathway:investigational agents with new implications for the cardiovascular field[J]. Expert Opin Inv Drug,2007,16(12):1879-1893.

[29] Kyler KE,Jones BL. The chicken or the egg:the role of IL-6 in pediatric obese and allergen-exposed asthma[J]. J Allergy Clin Immun,2023,152(6):1420-1422.

[30] Tyrrell DJ,Goldstein DR. Ageing and atherosclerosis:vascular intrinsic and extrinsic factors and potential role of IL-6[J]. Nat Rev Cardiol,2021,18(1):58-68.

[31] Mehrabi Nasab E,Hassanzadeh Makoei R,Aghajani H,et al. IL-33/ST2 pathway as upper-hand of inflammation in allergic asthma contributes as predictive biomarker in heart failure[J]. ESC Heart Fail,2022,9(6):3785-3790.

[32] Casale TB,Foggs MB,Balkissoon RC. Optimizing asthma management:role of long-acting muscarinic antagonists[J]. J Allergy Clin Immun,2022,150(3):557-568.

[33] Rebordosa C,Plana E,Rubino A,et al. Risk assessment of acute myocardial infarction and stroke associated with long-acting muscarinic antagonists,alone or in combination,versus long-acting β2-agonists[J]. Int J Chron Obstruct Pulmon Dis,2022,17:1715-1733.

[34] Qin J,Wang G,Han D. Long-term safety of tezepelumab in patients with asthma:a systematic review and meta-analysis of randomized controlled trials[J]. J Asthma,2024,2:1-10.

[35] Xu R,Fu J,Hu Y,et al. Roflumilast-mediated phosphodiesterase 4D inhibition reverses diabetes-associated cardiac dysfunction and remodeling :effects beyond glucose lowering[J]. Diabetes,2022,71(8):1660-1678.

[36]Xu B,Xu J,Cai N,et al. Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway[J]. Free Radical Bio Med,2021,163:281-296.

[37]White WB,Cooke GE,Kowey PR,et al. Cardiovascular safety in patients receiving roflumilast for the treatment of COPD[J]. Chest,2013,144(3):758-765.

[38] Villani AP,Pavel AB,Wu J,et al. Vascular inflammation in moderate-to-severe atopic dermatitis is associated with enhanced Th2 response[J]. Allergy,2021,76(10):3107-3121.

[39] Gibson PG,Prazma CM,Chupp GL,et al. Mepolizumab improves clinical outcomes in patients with severe asthma and comorbid conditions[J]. Respir Res,2021,22(1):171.

[40] Lee PH,Hong J,Jang AS. N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression[J]. Korean J Intern Med,2020,35(5):1229-1237.

[41] Pasupathy S,Tavella R,Grover S,et al. Early use of N-acetylcysteine with nitrate therapy in patients undergoing primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction reduces myocardial infarct size (the NACIAM trial [N-acetylcysteine in acute myocardial infarction])[J]. Circulation,2017,136(10):894-903.

相似文献/References:

[1]白春兰,张军.正五聚蛋白-3:新型心血管病炎性标志物[J].心血管病学进展,2016,(1):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
 BAI Chunlan,ZHANG Jun.Pentraxin-3: A Novel Inflammation Biomarker for Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2016,(3):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
[2]任茂佳,贺文帅,张琪,等.围绝经期对心血管疾病相关危险因素的影响[J].心血管病学进展,2019,(6):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
 REN Maojia,HE Wenshuai,ZHANG Qi,et al.Effects of Perimenopause on Cardiovascular Risk Factors[J].Advances in Cardiovascular Diseases,2019,(3):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
[3]尹琳 黄从新.JP2蛋白和心血管疾病的研究进展[J].心血管病学进展,2019,(7):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
 YIN Lin HUANG Congxin.Research Progress of JP2 Protein and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(3):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
[4]朱峰 汪汉 蔡琳.抗体与心血管疾病[J].心血管病学进展,2019,(7):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
 ZHU FengWANG HanCAI Lin.Antibodies and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(3):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
[5]邱明仙 王正龙 许官学.心肌肌球蛋白结合蛋白-C磷酸化与心血管疾病关系的研究进展[J].心血管病学进展,2019,(7):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
 QIU MingxianWANG ZhenglongXU Guanxue.Research Progress of the Relationship Between Cardiac Myosin Binding Protein-C and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(3):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
[6]姬楠楠 杨晓静 谢勇.单核细胞/高密度脂蛋白比值与心血管疾病的研究进展[J].心血管病学进展,2019,(7):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
 JI Nannan YANG Xiaojing XIE Yong.Monocyte/High-density Lipoprotein Ratio and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(3):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
[7]渠海贤 李涛 程流泉.人工智能在心脏磁共振成像中的应用进展[J].心血管病学进展,2019,(5):659.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.001]
[8]侯冬华 郝丽荣.长正五聚蛋白3在动脉粥样硬化和心血管疾病中作用研究的新进展[J].心血管病学进展,2019,(5):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
 HOU Donghua H AO Lirong.The Study of Atherosclerosis and Cardiovascular Diseases with Pentapycin 3[J].Advances in Cardiovascular Diseases,2019,(3):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
[9]张维 张恒 康品方.外泌体在心血管疾病中的研究进展[J].心血管病学进展,2019,(5):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
 Zhang WeiKang Pinfang.Exosome in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(3):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
[10]韦莹 刘书旺 李蕾 崔鸣.生长分化因子-15在心房颤动中的研究进展[J].心血管病学进展,2019,(8):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]
 WEI Ying,LIU Shuwang,LI Lei,et al.Growth Differentiation Factor-15 in Development of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2019,(3):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]

更新日期/Last Update: 2025-04-29