[1]杜孝亮 徐静 李樊丹 杨浩 吕湛.残余胆固醇在动脉粥样硬化性心血管疾病中的作用机制研究进展[J].心血管病学进展,2024,(8):732.[doi:10.16806/j.cnki.issn.1004-3934.202.08.013]
 DU Xiaoliang,XU Jing,LI Fandan,et al.Action Mechanism of Remnant Cholesterol and Atherosclerotic Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2024,(8):732.[doi:10.16806/j.cnki.issn.1004-3934.202.08.013]
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残余胆固醇在动脉粥样硬化性心血管疾病中的作用机制研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年8期
页码:
732
栏目:
综述
出版日期:
2024-08-25

文章信息/Info

Title:
Action Mechanism of Remnant Cholesterol and Atherosclerotic Cardiovascular Disease
作者:
杜孝亮 徐静 李樊丹 杨浩 吕湛
(川北医学院附属医院心血管内科,637000)
Author(s):
DU XiaoliangXU JingLI FandanYANG HaoLYU Zhan
(Department of CardiologyAffiliated Hospital of North Sichuan Medical College,Nanchong 637000SichuanChina)
关键词:
动脉粥样硬化心血管疾病残余胆固醇作用机制药物治疗
Keywords:
AtherosclerosisCardiovascular diseaseRemnant cholesterolAction Mechanism Drug treatment
DOI:
10.16806/j.cnki.issn.1004-3934.202.08.013
摘要:
动脉粥样硬化性心血管疾病已成为全球公共卫生面临的最大威胁之一,也是导致死亡的主要原因。低密度脂蛋白胆固醇是动脉粥样硬化疾病一级和二级预防的主要目标。然而将到推荐浓度,仍存在显著的残余心血管风险。越来越多的研究发现,残余胆固醇的水平与残余心血管风险密切相关。在中的作用机制尚不明确,重点介绍目前研究发现的作用机制这些机制主要包括激活炎症、参与氧化应激、促进易损斑块形成、加速血栓形成和引起胰岛素抵抗等。此外还讨论了未来可能用于控制的药物。
Abstract:
Atherosclerotic cardiovascular disease(ASCVD) ha become one of the greatest threats to global public health and the leading cause of death.,Lowering low-density lipoprotein cholesterol (LDL-C) is the vital target for primary and secondary prevention of atherosclerotic diseases.Nevertheless,patients with recommended concentrations in LDL-C still have a considerable residual risk of cardiovascular adverse events。Accumulating studies suggests that levels of remnant cholesterol(RC)were associated with residual risk of cardiovascular.The mechanisms underlying the effects of RC on ASCVD remain unclear.?This article highlights the mechanisms of action of RC that have been identified in current studies,which include activation of inflammation,involvement in oxidative stress,promotion of vulnerable plaque formation,acceleration of thrombosis,and insulin resistance. In addition,potential future drugs for RC control are discussed

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备注/Memo

备注/Memo:
基金项目:川北医学院校级科研发展基金(CBY22-QNA23)通信作者:吕湛,E-mail:Doctor_LZ@163.com
更新日期/Last Update: 2024-09-13