[1]李乐亮,综述,李萍,等.炎症标志物与颈动脉粥样斑块的稳定性[J].心血管病学进展,2016,(3):219-224.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.001]
 LI Leliang,LI Ping.Stability of Inflammatory Markers and Carotid Artery Plaque[J].Advances in Cardiovascular Diseases,2016,(3):219-224.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.001]
点击复制

炎症标志物与颈动脉粥样斑块的稳定性()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年3期
页码:
219-224
栏目:
主题综述
出版日期:
2016-06-20

文章信息/Info

Title:
Stability of Inflammatory Markers and Carotid Artery Plaque
作者:
李乐亮综述李萍审校
南昌大学第二附属医院心血管内科,江西 南昌 330006
Author(s):
LI Leliang LI Ping
Department of Cardiology,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China
关键词:
动脉粥样硬化 炎症 斑块 生物标志物
Keywords:
Atherosclerosis inflammation plaque biomarkers
分类号:
R543.1; R446.11+9
DOI:
10.16806/j.cnki.issn.1004-3934.2016.03.001
文献标志码:
A
摘要:
动脉粥样硬化是一种全身系统性疾病,主要影响人体的大、中动脉。同时其与炎症反应密切相关,因炎症反应产生的一些生物标志物,如C反应蛋白和白介素-6等可作为心血管终点事件的可靠预测指标。既往的一些临床研究多为探索炎症标志物与亚临床的动脉粥样硬化之间的关系,即颈动脉内膜中层厚度。然而,炎症标志物与颈动脉粥样斑块稳定性之间的关联尚不可知。现综述炎症生物标志物与颈动脉粥样斑块稳定性之间的关系。
Abstract:
Atherosclerosis is a systemic disease that primarily affects the body's large arteries. At the same time it is closely related to inflammation, some of the biomarkers produced by inflammation, such as C-reactive protein and interleukin-6 can be used as a reliable predictor of cardiovascular outcome events. Some clinical studies exploring the relationship between mostly markers of inflammation and subclinical atherosclerosis, that is, carotid intima-media thickness. However, markers of inflammation associated with carotid plaque stability still unknown. This article reviewed the relationship between biomarkers of inflammation and carotid artery plaque stability.

参考文献/References:

[1] Ross R. Atherosclerosis—an inflammatory disease[J]. N Engl J Med, 1999, 340(2): 115-126.
[2] de Weerd M, Greving JP, Hedblad B, et al. Prevalence of asymptomatic carotid artery stenosis in the general population an individual participant data meta-analysis[J]. Stroke, 2010, 41(6): 1294-1297.
[3] Nagai Y, Kitagawa K, Sakaguchi M, et al. Significance of earlier carotid atherosclerosis for stroke subtypes[J]. Stroke, 2001, 32(8): 1780-1785.
[4] Hermus L, Lefrandt JD, Tio RA, et al. Carotid plaque formation and serum biomarkers[J]. Atherosclerosis, 2010, 213(1): 21-29.
[5] Norata GD, Ballantyne CM, Catapano AL. New therapeutic principles in dyslipidaemia: focus on LDL and Lp(a)lowering drugs[J]. Eur Heart J, 2013, 34(24): 1783-1789.
[6] Ammirati E, Bozzolo EP, Contri R, et al. Cardiometabolic and immune factors associated with increased common carotid artery intima-media thickness and cardiovascular disease in patients with systemic lupus erythematosus[J]. Nutr Metab Cardiovasc Dis, 2014, 24(7): 751-759.
[7] Ammirati E, Moroni F, Magnoni M, et al. The role of T and B cells in human atherosclerosis and atherothrombosis[J]. Clin Exp Immunol, 2015, 179(2): 173-187.
[8] Sternberg Z, Ghanim H, Gillotti KM, et al. Flow cytometry and gene expression profiling of immune cells of the carotid plaque and peripheral blood[J]. Atherosclerosis, 2013, 229(2): 338-347.
[9] Halvorsen DS, Johnsen SH, Mathiesen EB, et al. The association between inflammatory markers and carotid atherosclerosis is sex dependent: the Troms Study[J]. Cerebrovasc Dis, 2009, 27(4): 392-397.
[10] Chapman CML, Beilby JP, McQuillan BM, et al. Monocyte count, but not C-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosis[J]. Stroke, 2004, 35(7): 1619-1624.
[11] Thiele JR, Habersberger J, Braig D, et al. Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy[J]. Circulation, 2014, 130(1): 35-50.
[12] Stancel N, Chen CC, Ke LY, et al. Interplay between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis[J]. Clin Chem, 2016, 62(2): 320-327.
[13] Danesh J, Lewington S, Thompson SG, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis[J]. JAMA, 2005, 294(14): 1799-1809.
[14] Green D, Foiles N, Chan C, et al. Elevated fibrinogen levels and subsequent subclinical atherosclerosis: the CARDIA Study[J]. Atherosclerosis, 2009, 202(2): 623-631.
[15] Lepedda AJ, Cigliano A, Cherchi GM, et al. A proteomic approach to differentiate histologically classified stable and unstable plaques from human carotid arteries[J]. Atherosclerosis, 2009, 203(1): 112-118.
[16] Borissoff JI, Spronk HMH, Ten CH. The hemostatic system as a modulator of atherosclerosis[J]. N Engl J Med, 2011, 364(18): 1746-1760.
[17] Debing E, Peeters E, Demanet C, et al. Markers of inflammation in patients with symptomatic and asymptomatic carotid artery stenosis: a case-control study[J]. Vasc Endovasc Surg, 2008, 42(2): 122-127.
[18] Pelisek J, Rudelius M, Zepper P, et al. Multiple biological predictors for vulnerable carotid lesions[J]. Cerebrovasc Dis, 2009, 28(6): 601-610.
[19] Kampoli AM, Tousoulis D, Papageorgiou N, et al. Matrix metalloproteinases in acute coronary syndromes: current perspectives[J]. Curr Top Med Chem, 2012, 12(10): 1192-1205.
[20] Abbas A, Aukrust P, Russell D, et al. Matrix metalloproteinase 7 is associated with symptomatic lesions and adverse events in patients with carotid atherosclerosis[J]. PLoS One, 2014, 9(1): e84935.
[21] Orbe J, Montero I, Rodriguez JA, et al. Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis[J]. J Thromb Haemost, 2007, 5(1): 91-97.
[22] Puz P, Lasek-Bal A, Ziaja D, et al. Inflammatory markers in patients with internal carotid artery stenosis[J]. Arch Med Sci, 2013, 9(2): 254-260.
[23] Abbas A, Aukrust P, Dahl TB, et al. High levels of S100A12 are associated with recent plaque symptomatology in patients with carotid atherosclerosis[J]. Stroke, 2012, 43(5): 1347-1353.
[24] Sugioka K, Naruko T, Hozumi T, et al. Elevated levels of neopterin are associated with carotid plaques with complex morphology in patients with stable angina pectoris[J]. Atherosclerosis, 2010, 208(2): 524-530.
[25] Koutouzis M, Rallidis LS, Peros G, et al. Serum interleukin-6 is elevated in symptomatic carotid bifurcation disease[J]. Acta Neurol Scand, 2009, 119(2): 119-125.
[26] Garcia BA, Ruiz C, Chacon P, et al. High-sensitivity C-reactive protein in high-grade carotid stenosis: risk marker for unstable carotid plaque[J]. J Vasc Surg, 2003, 38(5): 1018-1024.
[27] Holm S, Ueland T, Dahl TB, et al. Fatty acid binding protein 4 is associated with carotid atherosclerosis and outcome in patients with acute ischemic stroke[J]. PLoS One, 2011, 6(12): e28785.
[28] Shindo A, Tanemura H, Yata K, et al. Inflammatory biomarkers in atherosclerosis: pentraxin 3 can become a novel marker of plaque vulnerability[J]. PLoS One, 2014, 9(6): e100045.
[29] Edsfeldt A, Nitulescu M, Grufman H, et al. Soluble urokinase plasminogen activator receptor is associated with inflammation in the vulnerable human atherosclerotic plaque[J]. Stroke, 2012, 43(12): 3305-3312.
[30] Norata GD, Raselli S, Grigore L, et al. Small dense LDL and VLDL predict common carotid artery IMT and elicit an inflammatory response in peripheral blood mononuclear and endothelial cells[J]. Atherosclerosis, 2009, 206(2): 556-562.
[31] Martín-Ventura JL, Madrigal-Matute J, Muñoz-Garcia B, et al. Increased CD74 expression in human atherosclerotic plaques: contribution to inflammatory responses in vascular cells[J]. Cardiovasc Res, 2009, 83(3): 586-594.
[32] Pelisek J, Well G, Reeps C, et al. Neovascularization and angiogenic factors in advanced human carotid artery stenosis[J]. Circ J, 2012, 76(5): 1274-1282.
[33] Jaipersad AS, Shantsila A, Lip GYH, et al. Expression of monocyte subsets and angiogenic markers in relation to carotid plaque neovascularization in patients with pre-existing coronary artery disease and carotid stenosis[J]. Ann Med, 2014, 46(7): 530-538.
[34] Camici PG, Rimoldi OE, Gaemperli O, et al. Non-invasive anatomic and functional imaging of vascular inflammation and unstable plaque[J]. Eur Heart J, 2012, 33(11): 1309-1317.
[35] Ammirati E, Magnoni M, Camici PG. Need for new non-invasive imaging strategies to identify high-risk asymptomatic patients with carotid stenosis[J]. In J Cardiol, 2013, 168(4): 4342-4343.
[36] Ammirati E, Moroni F, Norata GD, et al. Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis[J]. Mediators Inflamm,2015,2015:718329. doi:10.1155/2015/718329.

相似文献/References:

[1]白春兰,张军.正五聚蛋白-3:新型心血管病炎性标志物[J].心血管病学进展,2016,(1):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
 BAI Chunlan,ZHANG Jun.Pentraxin-3: A Novel Inflammation Biomarker for Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2016,(3):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
[2]阎萌,田芳,综述,等.程序性坏死与动脉粥样硬化[J].心血管病学进展,2016,(2):139.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.011]
 YAN Meng,TIAN Fang,TIAN Ye.Necroptosis and Atherosclerosis[J].Advances in Cardiovascular Diseases,2016,(3):139.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.011]
[3]陈芡茹,综述,叶飞,等.心血管疾病治疗新目标:脂蛋白相关磷脂酶A2[J].心血管病学进展,2016,(2):188.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.024]
 CHEN Qianru,YE Fei.Novel Therapeutic Target of Cardiovascular Disease:Lipoprotein Associated Phospholipase A2[J].Advances in Cardiovascular Diseases,2016,(3):188.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.024]
[4]杨娟,综述,王佑华,等.肠道菌群与血管内炎症[J].心血管病学进展,2016,(3):263.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.012]
 YANG Juan,WANG Youhua,YUAN Suyun.Relationship Between Gut Microbiota and Vascular Inflammation[J].Advances in Cardiovascular Diseases,2016,(3):263.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.012]
[5]夏平,杨浩.炎症与心房颤动相关性的研究进展[J].心血管病学进展,2015,(5):637.[doi:10.3969/j.issn.1004-3934.2015.05.030]
 XIA Ping,YANG Hao.Research Progress of Inflammation Associated with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2015,(3):637.[doi:10.3969/j.issn.1004-3934.2015.05.030]
[6]耿春晖 关秀茹.MicroRNA作为动脉粥样硬化的诊断生物标志物的研究进展[J].心血管病学进展,2019,(7):996.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.008]
 GENG Chunhui,GUAN Xiuru.microRNA as a Diagnostic Biomarker for Atherosclerosis[J].Advances in Cardiovascular Diseases,2019,(3):996.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.008]
[7]乐健 何胜虎.前蛋白转化酶枯草溶菌素9致动脉粥样硬化的机制研究进展[J].心血管病学进展,2019,(7):1000.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.009]
 YUE Jian,HE Shenghu.Advances in the mechanism of PCSK9-induced atherosclerosis[J].Advances in Cardiovascular Diseases,2019,(3):1000.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.009]
[8]武亚琳,梁斌,杨志明.NLRP3/IL-1β途径的促动脉粥样硬化作用及临床应用[J].心血管病学进展,2019,(6):943.[doi:10.16806/j.cnki.issn.1004-3934.2016.06.026]
 WU Yalin,LIANG Bin,YANG Zhiming.The Role of NLRP3/IL-1in Atherosclerosis and Clinical Application[J].Advances in Cardiovascular Diseases,2019,(3):943.[doi:10.16806/j.cnki.issn.1004-3934.2016.06.026]
[9]李琦玉 ?张宁 陈婧 黄浙勇.动脉粥样硬化的抗血小板分子靶向治疗[J].心血管病学进展,2019,(5):701.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.010]
 LI Qiyu,ZHANG Ning,CHEN Jing,et al.Anti-Platelet Molecular Targeted Therapy or Atherosclerosis[J].Advances in Cardiovascular Diseases,2019,(3):701.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.010]
[10]侯冬华 郝丽荣.长正五聚蛋白3在动脉粥样硬化和心血管疾病中作用研究的新进展[J].心血管病学进展,2019,(5):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
 HOU Donghua H AO Lirong.The Study of Atherosclerosis and Cardiovascular Diseases with Pentapycin 3[J].Advances in Cardiovascular Diseases,2019,(3):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81560079); 江西省自然基金重大项目(20152ACB20022); “赣鄱英才555工程”领军人才培养计划 作者简介:李乐亮(1989—),在读硕士,主要从事高血压研究。Email: lileliang4234478@163.com 通信作者:李萍(1968—),博士生导师,教授,主任医师,博士,主要从事高血压和血管病研究。Email: lipingsydney@163.com
更新日期/Last Update: 2016-05-25