[1]李琦玉 ?张宁 陈婧 黄浙勇.动脉粥样硬化的抗血小板分子靶向治疗[J].心血管病学进展,2019,(5):701-704.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.010]
 LI Qiyu,ZHANG Ning,CHEN Jing,et al.Anti-Platelet Molecular Targeted Therapy or Atherosclerosis[J].Advances in Cardiovascular Diseases,2019,(5):701-704.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.010]
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动脉粥样硬化的抗血小板分子靶向治疗()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年5期
页码:
701-704
栏目:
综述
出版日期:
2019-08-25

文章信息/Info

Title:
Anti-Platelet Molecular Targeted Therapy or Atherosclerosis
作者:
李琦玉 ?张宁 陈婧 黄浙勇
(复旦大学附属中山医院心内科 上海市心血管病研究所,上海 200032)
Author(s):
LI Qiyu ZHANG Ning CHEN Jing WANG Qiaozi HUANG Zheyong
(Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China)
关键词:
动脉粥样硬化分子靶向治疗血小板
Keywords:

font-size: 12pt">Atherosclerosis Molecular targeted therapy Platelet

DOI:
10.16806/j.cnki.issn.1004-3934.2019.05.010
摘要:
动脉粥样硬化是动脉硬化的常见形式,以动脉内膜下的脂质沉积开始缓慢发展,逐渐出现管腔狭窄、痉挛或堵塞,继而出现缺血性心脏病,已成为心血管疾病导致死亡的主要原因。现有的治疗手段,并不能有效地降低心血管事件的发生率。近年来,分子靶向治疗成为治疗动脉粥样硬化的热点。而针对血小板在动脉粥样硬化发生发展中的作用,以及血栓堵塞血管发生心肌梗死和卒中的危害性,着重介绍抗血小板分子靶向治疗的最新进展。
Abstract:
Atherosclerosis, a common form of arteriosclerosis,starts with lipid deposition under the arterial intima and develops into lumen stenosis, spasm or blockage which results in ischemic heart disease. Current treatments are not effective reducing the incidence of cardiovascular events whose main mortality are caused by atherosclerosis. In recent years, molecular targeted therapy has become a hot spot in the treatment of atherosclerosis. Considering the role of platelets in the initiation and development of atherosclerosis, and the harm of thromboembolic occlusion in myocardial infarction and stroke, this review will focus on the latest progress of anti-platelet molecular targeted therapy

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备注/Memo

备注/Memo:
(基金项目:国家自然科学基金(81570223,81500201);国家自然青年基金(81600196);上海市科委基础处自然科学基金(15ZR1434100)收稿日期:2019-02-13
更新日期/Last Update: 2019-12-23