[1]杨娟,综述,王佑华,等.肠道菌群与血管内炎症[J].心血管病学进展,2016,(3):263-267.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.012]
 YANG Juan,WANG Youhua,YUAN Suyun.Relationship Between Gut Microbiota and Vascular Inflammation[J].Advances in Cardiovascular Diseases,2016,(3):263-267.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.012]
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肠道菌群与血管内炎症()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年3期
页码:
263-267
栏目:
综述
出版日期:
2016-06-20

文章信息/Info

Title:
Relationship Between Gut Microbiota and Vascular Inflammation
作者:
杨娟13综述王佑华2苑素云3审校
1.上海中医药大学研究生院,上海 200032; 2.上海中医药大学附属龙华医院心内科,上海 200032; 3.上海中医药大学附属龙华医院中医示范科,上海 200032
Author(s):
YANG Juan13WANG Youhua2YUAN Suyun3
1.Graduate School, Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China; 2.Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China; 3.Department of Demonstration,Longhua H
关键词:
肠道菌群 血管 炎症
Keywords:
Gut microbiota Vascular Inflammation
分类号:
R543
DOI:
10.16806/j.cnki.issn.1004-3934.2016.03.012
文献标志码:
A
摘要:
最新研究表明,肠道菌群与血管内炎症性疾病具有重要关联,肠道菌群通过多种机制促进肥胖及动脉粥样硬化。同时,肠道菌群可通过破损的肠黏膜进入血循环,诱发内毒素血症,引起多种炎症性疾病。针对上述发病机制,近年来多种益生菌在临床与实验研究中均表现出一定效果,如抑制炎症状态、改善肠道症状、恢复菌群稳态等。现对近年肠道菌群与血管内炎症性疾病的相关性研究做一综述。
Abstract:
Recent studies have showed the important link between gut microbiota and vascular inflammation. Gut microbiota promotes the occurrence of obesity and atherosclerosis through several different kinds of mechanisms. Additionally, gut microbiota may enter blood circulation through damaged intestinal mucosa, leading to endotoxemia and many kinds of infectious diseases. Targeting the above pathogenesis, probiotics exhibit unique therapeutic effects, such as inhibiting the inflammatory state, improving bowel symptoms, restoring flora steady and more. By reviewing the latest research studies on this topic, we are able to look into the relationship between gut microbiota and vascular inflammatory diseases.

参考文献/References:

[1] Biedermann L,Rogler G.The intestinal microbiota:its role in health and disease[J].Eur J Pediatr,2015,174(2):151-167.
[2] Eckburg PB,Bik EM,Bernstein CN,et al.Diversity of the human intestinal microbial flora[J]. Science,2005,308(5728):1635-1638.
[3] Nuding S,Antoni L,Stange EF.The host and the flora[J].Dig Dis,2013,31(3-4):286-292.
[4] Sargent J.Obesity:rethinking inflammation and adipocyte homeostasis[J].Nat Rev Endocrinol,2014,10(8):446.
[5] van GreevenbroekMM,Schalkwijk CG,Stehouwer CD.Obesity-associated low-grade inflammation in type 2 diabetes mellitus:causes and consequences[J].Neth J Med,2013,71(4):174-187.
[6] El Kaoutari A,Armougom F,Gordon JI,et al.The abundance and variety of carbohydrate-active enzymesin the human gut microbiota[J].Nat Rev Microbiol,2013,11(7):497-504.
[7] Tang C,Ahmed K,Gille A,et al.Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes[J].Nat Med,2015,21(2):173-177.
[8] Kimura I,Ozawa K,Inoue D,et al.The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43[J].Nat Commun,2013,4:1829.
[9] Kasai C,Sugimoto K,Moritani I,et al.Comparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population,as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing[J].BMC Gastroenterol,2015,15:100.
[10] 彭喜春,黄嘉成.肠道梭菌在机体能量过度摄入中的作用[J].现代食品科技,2014,3:262-265.
[11] Jihad B,Raymond F,Julnar M,et al.Obesity as a risk factor for clostridium difficile infection[J].Clin Infect Dis,2013,57(4):489-493.
[12] Wang H,Eckel RH.Lipoprotein lipase:from gene to obesity[J].Am J Physiol Endocrinol Metab,2009,297(2):E271-288.
[13] Kotzbeck P,Zechner R.Angiopoietin-like 4:an endogenous break of intestinal lipid digestion[J].Mol Metab,2014,3(2):88-89.
[14] Backhed F, Manchester JK, Semenkovich CF,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proc Natl Acad Sci USA,2007,104(3):979-984.
[15] 傅娟,谷翔.游离脂肪酸与冠心病之间的关系及发展[J].医药前沿,2012,27:149-150.
[16] Jaimes A,Ping H,Runxia T,et al.Human glomerular endothelium:interplay among glucose,free fatty acids,angiotensin Ⅱ,and oxidative stress[J].Am J Physiol Renal Physiol,2010,298(1):F125-F132.
[17] Zeneng W,Klipfell E,Bennett BJ,et al.Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease[J]. Nature,2011,472(7341):57-63.
[18] Vaishnavi C.Translocation of gut flora and its role in sepsis[J].Indian J Med Microbiol,2013,31(4):334-342.
[19] Wright SD,Ramos RA,Tobias PS,et al.CD14,a receptor for complexes of lipopolysaceharide(LPS)and LPS binding protein[J].Science,1990,249(4975):143-1433.
[20] Mahalle N,Garg M,Kulkarni M,et al.Association of inflammatory cytokines with traditional and nontraditional cardiovascular risk factors in Indians with known coronary artery disease[J].Ann Med Health Sci Res,2014,4(5):706-712.
[21] González GE,Rhaleb NE,D'Ambrosio MA,et al.Deletion of interleukin-6 prevents cardiac inflammation,fibrosis and dysfunction without affecting blood pressure in angiotensin Ⅱ-high salt-induced hypertension[J]. J Hypertens,2015,33(1):144-152.
[22] Fedacko J,Singh RB,Gupta A.Inflammatory mediators in chronic heart failure in North India[J].Acta Cardiol,2014,69(4):391-398.
[23] Gedikli O, Dogan A, Altuntas I, et al. Inflammatory markers according to types of atrial fibrillation[J]. Int J Cardiol, 2007,120(2):193-197.
[24] Hussein AA,Gottdiener JS,Bartz TM,et al.Inflammation and sudden cardiac death in a community-based population of older adults:the Cardiovascular Health Study[J].Heart Rhythm,2013,10(10):1425-1432.
[25] Tena D,Losa C,Medina MJ,et al.Peritonitis caused by Bifidobacterium longum:case report and literature review[J].Anaerobe,2014,27:27-30.
[26] Zbinden A,Zbinden R,Berger C,et al.Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy[J]. Neonatology,2014,107(1):56-59.
[27] Sánchez B,González-Rodríguez I,Arboleya S,et al.The effects of Bifidobacterium breve on immune mediators and proteome of HT29 cells monolayers[J].Biol Med Res Int, 2015,2015:479140.
[28] Presti I,D'Orazio G,Labra M,et al.Evaluation of the probiotic properties of new Lactobacillus and Bifidobacterium strains and their in vitro effect[J].Appl Microbiol Biotechnol,2015,99(13):5613-5626.
[29] Llopis M,Antolin M,Carol M,et al.Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa[J].Inflamm Bowel Dis,2009,15(2):275-283.
[30] Alexandre Y,le Berre R,Barbier G,et al.Screening of Lactobacillus spp. for the prevention of Pseudomonas aeruginosa pulmonary infections[J].BMC Microbiol, 2014,14:107.
[31] Seil S,Mary EM,Si C,et al.Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma[J].Respir Res,2014,15:46.
[32] Koulis C,Chen YC,Hausding C,et al.Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice[J].Arterioscler Thromb Vasc Biol,2014,34(3):516-525.
[33] Kawahara T,Takahashi T,Oishi K,et al.Consecutive oral administration of Bifidobacterium longum MM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model[J].Microbiol Immunol,2015,59(1):1-12.
[34] Underwood MA,Arriola J,Gerber CW,et al.Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis:alterations in inflammation, innate immune response, and the microbiota[J].Pediatr Res,2014,76(4):326-333.
[35] Ling Z,Liu X,Cheng Y,et al.Clostridium butyricum combined with Bifidobacterium infantis probiotic mixture restores fecal microbiota and attenuates systemic inflammation in mice with antibiotic-associated diarrhea[J].Biomed Res Int,2015,2015:582048.
[36] Wang Y,Xie J,Li Y,et al.Probiotic Lactobacillus casei Zhang reduces pro-inflammatory cytokine production and hepatic inflammation in a rat model of acute liver failure[J].Eur J Nutr,2016,55(2):821-831.
[37] Miyoshi M,Ogawa A,Higurashi S,et al.Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice[J].Eur J Nutr,2014,53(2):599-606.
[38] Toral M,Gomez-Guzman M,Jimenez R,et al.The probiotic Lactobacillus coryniformis CECT5711 reduces the vascular pro-oxidant and pro-inflammatory status in obese mice[J].Clin Sci(Lond),2014,127(1):33-45.
[39] Novotny Núñez I, Maldonado Galdeano C, de Moreno de LeBlanc A,et al.Lactobacillus casei CRL 431 administration decreases inflammatory cytokines in a diet-induced obese mouse model[J].Nutrition,2015,31(7-8):1000-1007.
[40] Huan W,Jing G,Wenfeng W,et al.Are there any different effects of Bifidobacterium,Lactobacillus and Streptococcus on intestinal sensation,barrier function and intestinal immunity in PI-IBS mouse model?[J]. PLoS One,2014, 9(3):e90153.
[41] Cani PD,Possemiers S,van de Wiele T.Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability[J].Gut,2009,58:1091-1093.
[42] Hercia M,Livia T,Karina S,et al.Effects of probiotics on glycemic control and inflammation in type 2 diabetes mellitus:a randomized,double-blind, placebo-controlled study[J].FASEB J,2015, 29(meeting abstract):9226.
[43] Tripolt NJ,Leber B,Blattl D,et al.Short communication:effect of supplementation with Lactobacillus casei Shirota on insulin sensitivity,β-cell function, and markers of endothelial function and inflammation in subjects with metabolic syndrome—A pilot study[J].J Dairy Sci,2013,96(1):89-95.
[44] Canxia H,Yujuan S,Wei S.Targeting gut microbiota as a possible therapy for diabetes[J].Nutr Res,2015,35(5):361-367.
[45] 赵莹,付军.肠道菌群与心血管疾病的研究进展[J].中国老年学杂志,2014,34(5): 1443-1444.
[46] Rerksuppaphol S,Rerksuppaphol LA.Randomized Double-blind Controlled Trial of Lactobacillus acidophilus plus Bifidobacterium bifidum versus Placebo in Patients with Hypercholesterolemia[J].J Clin Diagn Res,2015,9(3):KC01-04.
[47] Minami J,Kondo S,Yanagisawa N,et al.Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial[J].J Nutr Sci,2015,4:e17.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(81328025); 上海市自然科学基金项目(12ZR1432200); 国家中医临床研究基地业务建设科研专项(JDZX2012114) 作者简介:杨娟(1989—),住院医师,在读硕士,主要从事中医药防治心血管疾病研究。Email:18321899283@163.com 通信作者:王佑华(1972—),副主任医师,博士后,主要从事中医药防治心血管疾病研究。Email: doctorwyh@163.com 苑素云(1971—),主任医师,博士,主要从事中医药防治心血管疾病研
更新日期/Last Update: 2016-05-25