[1]康雅隆 齐鸿飞 葛腾 彭涛 余婷 剧嘉欣 程草草 关芳 余湖斌 王海芳.小干扰RNA降脂药物英克司兰在心血管疾病中的研究进展[J].心血管病学进展,2024,(6):529.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.012]
 KANG Yalong,QI Hongfei,GE Teng,et al.siRNA Lipid-Lowering Drug Inclisiran in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2024,(6):529.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.012]
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小干扰RNA降脂药物英克司兰在心血管疾病中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年6期
页码:
529
栏目:
综述
出版日期:
2024-06-25

文章信息/Info

Title:
siRNA Lipid-Lowering Drug Inclisiran in Cardiovascular Diseases
作者:
康雅隆 齐鸿飞 葛腾 彭涛 余婷 剧嘉欣 程草草 关芳 余湖斌 王海芳
(陕西中医药大学 陕西省及咸阳市中西医结合心血管病防治重点实验室,陕西 咸阳712000)
Author(s):
KANG YalongQI HongfeiGE TengPENG TaoYU TingJU JiaxinCHENG CaocaoGUAN fangYU HubinWANG Haifang
(Shaanxi University of Chinese Medicine,Shaanxi & Xianyang Key Laboratory of Integrated Traditional and Western Medicine for Prevention and Treatment of Cardiovascular Diseases,Xianyang 712000,Shaanxi,China)
关键词:
心血管疾病动脉粥样硬化英克司兰小干扰RNA血脂管理
Keywords:
Cardiovascular diseasesAtherosclerosisInclisiranSmall interfering RNALipid management
DOI:
10.16806/j.cnki.issn.1004-3934.2024.06.012
摘要:
动脉粥样硬化性心血管疾病(ASCVD)是中国城乡居民死亡的第一位死因。动脉粥样硬化是一种血管慢性炎症性病变,也是ASCVD的病变基础,其主要原因是脂质代谢障碍,故降低低密度脂蛋白胆固醇成为防治ASCVD的重要手段。小干扰RNA是一类新型降血脂药。目前,针对该类药物的循证证据和实践经验较少。首个小干扰RNA降脂药物英克司兰于2023年8月在中国获批上市。现介绍英克司兰治疗动脉粥样硬化的机制、与其他降脂药物合用的情况,以及其安全性和不良反应,以期为此类药物的临床应用提供参考。
Abstract:
Atherosclerotic cardiovascular disease (ASCVD) is the first cause of death for urban and rural residents in China. Atherosclerosis is a chronic vascular inflammation and the pathological basis of ASCVD,and its main reason is lipid metabolism disorder. Therefore,reducing low-density lipoprotein cholesterol has become an important approach for the prevention and treatment of ASCVD. Small interfering RNA lipid-lowering drugs are novel lipid-lowering drugs. At present,there is little evidence-based evidence and practical experience for this class of drugs. Inclisiran,the first small interfering RNA lipid-lowering drug,was approved for sale in China in August 2023. In this article,we will review the anti-atherosclerostic mechanisms of inclisiran,its combined application with other lipid-lowering drugs,and the safety and adverse effects,and thus to provide supportive evidence for the future clinical application of more siRNA lipid-lowering drugs

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更新日期/Last Update: 2024-07-26