[1]张严 宋可欣 姚朱华.钠-葡萄糖共转运蛋白2抑制剂对心肾综合征获益机制的研究进展[J].心血管病学进展,2024,(5):389.[doi:10.16806/j.cnki.issn.1004-3934.2023.05.002]
 ZHANG Yan,SONG Kexin,YAO Zhuhua.Advances in the Beneficial Mechanisms of Sodium-Glucose Co-Transporter 2 Inhibitor in Cardiorenal Syndrome[J].Advances in Cardiovascular Diseases,2024,(5):389.[doi:10.16806/j.cnki.issn.1004-3934.2023.05.002]
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钠-葡萄糖共转运蛋白2抑制剂对心肾综合征获益机制的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年5期
页码:
389
栏目:
综述
出版日期:
2024-05-25

文章信息/Info

Title:
Advances in the Beneficial Mechanisms of Sodium-Glucose Co-Transporter 2 Inhibitor in Cardiorenal Syndrome
作者:
张严12 宋可欣34 姚朱华25
(1.天津医科大学研究生院,天津300070;2.天津医科大学人民医院临床学院,天津300121;3.河北医科大学研究生院,河北 石家庄 050017 ;4.河北省人民医院心内科,河北 石家庄 050051 ;5.南开大学人民医院转化医学研究院,天津300121)
Author(s):
ZHANG Yan12SONG Kexin34YAO Zhuhua25
(1.Graduate School of Tianjin Medical UniversityTianjin300070China2. Tianjin Union Medical Center,Tianjin Medical University,Tianjin300121China3.Graduate School of Hebei Medical University Shijiazhuang050017China4.Department of CardiologyHebei General Hospital Shijiazhuang050051China5.The Institute of Translational MedicineTianjin Union Medical Center of Nankai University Tianjin 300121China)
关键词:
心肾综合征心血管疾病肾脏疾病钠-葡萄糖共转运蛋白2抑制剂心肾保护
Keywords:
Crdiorenal syndrome Cardiovascular disease Kidney disease Sodium-glucose co-transporter 2 inhibitorCardiorenal protection
DOI:
10.16806/j.cnki.issn.1004-3934.2023.05.002
摘要:
心肾综合征(CRS)是一种临床综合征其发生发展与血流动力学改变、神经体液因素异常持续激活、炎症、氧化应激、贫血等因素密切相关。钠葡萄糖共转运蛋白2抑制剂(SGLT2i)作为一种临床广泛应用的新型口服降糖药物,在最近的大型临床研究对心血管疾病和肾脏疾病都显示出了一致的益处。因此SGLT2i有望成为改善CRS患者预后的重要治疗手段。现总结最近SGLT2i在大型临床试验的心肾获益证据,并从CRS病理生理角度探讨其独立于降糖作用以外可能的心肾共同获益机制。
Abstract:
Cardiorenal syndrome (CRS) is a clinical syndrome characterized by hemodynamic changes,abnormal continuous act ivation of neurohumoral factors,inflammation,oxidative stress and anemia. Recent large clinical studies have consistently shown that sodium-glucose co -transporter 2 inhibitor (SGLT2i),a novel oral hypoglycemic agent,provide benefits for both cardiovascular and kidney diseases. This article aims to summarize the recent evidence of cardiorenal benefit from SGLT2i in large clinical trials and explore the potential mechanism of this benefit in treating cardiorenal syndrome,independent of its hypoglycemic effect,from the pathophysiological perspective.

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更新日期/Last Update: 2024-06-28