[1]杜旭江 吕依晨 王少兰 王海芳 韩曼.孕烷X受体在心血管疾病中的作用机制及中药调控研究进展[J].心血管病学进展,2022,(6):547.[doi:10.16806/j.cnki.issn.1004-3934.2022.06.017]
 DU Xujiang,LV Yichen,WANG Shaolan,et al.Pregnane X Receptor in Cardiovascular Disease and Intervention Mechanism of Traditional Chinese Medicine[J].Advances in Cardiovascular Diseases,2022,(6):547.[doi:10.16806/j.cnki.issn.1004-3934.2022.06.017]
点击复制

孕烷X受体在心血管疾病中的作用机制及中药调控研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年6期
页码:
547
栏目:
综述
出版日期:
2022-06-25

文章信息/Info

Title:
Pregnane X Receptor in Cardiovascular Disease and Intervention Mechanism of Traditional Chinese Medicine
作者:
杜旭江 吕依晨 王少兰 王海芳 韩曼
(陕西中医药大学陕西省中西医结合心血管病防治重点实验室,陕西 咸阳 712046)
Author(s):
DU XujiangLV YichenWANG ShaolanWANG HaifangHAN Man
(Shaanxi Key Laboratory of Integrated Traditional and Western Medicine for Prevention and Treatment of Cardiovascular Diseases,Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China)
关键词:
孕烷X受体心血管疾病内皮损伤糖脂代谢紊乱中药干预
Keywords:
Pregnane X receptorCardiovascular diseaseEndothelial injuryGlycolipid metabolism disorderChinese medicine intervention
DOI:
10.16806/j.cnki.issn.1004-3934.2022.06.017
摘要:
心血管疾病多由糖脂代谢紊乱与血管内皮损伤引起。作为核受体超家族的一员,孕烷X受体(PXR)在心血管组织中表达并可被多种内外源异物活化,除经典的药物解毒效应,PXR在胰岛素敏感性、糖脂稳态、改善动脉粥样硬化和血管功能等方面有一定作用。现就PXR参与调控动脉粥样硬化、调控血压、减缓心力衰竭进程等心血管疾病的作用分子机制以及中药激活PXR在心血管疾病治疗的机制做简单介绍,以期为今后的研究提供参考。
Abstract:
Cardiovascular diseases are mostly caused by glycolipid metabolism disorders and vascular endothelial damage. As a member of the nuclear receptor superfamily,pregnane X receptor (PXR) is expressed in cardiovascular tissues and activated by a variety of xenobiotics and endobiotics,in addition to its conventional function in drug detoxification,PXR also plays a role in insulin sensitivity,glycolid and lipid homeostasis,improvement of atherosclerosis and vascular function. In this review,we discuss the differential role of PXR in the atherosclerosis,blood pressure and heart failure,and the mechanism of traditional Chinese medicine activating PXR in the treatment of cardiovascular diseases, so as to provide reference for future studies

参考文献/References:

[1]Jokinen E. Obesity and cardiovascular disease[J]. Minerva Pediatr,2015,67(1):25-32.

[2]Wang S,Lei T,Zhang K,et al. Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells[J]. J Biol Chem,2014,289(43):30075-30081.

[3]Oladimeji PO,Chen T. PXR:more than just a master xenobiotic receptor[J]. Mol Pharmacol,2018,93(2):119-127.

[4]Chai SC,Wright WC,Chen T. Strategies for developing pregnane X receptor antagonists:implications from metabolism to cancer[J]. Med Res Rev,2020,40(3):1061-1083.

[5]Swales KE,Moore R,Truss NJ,et al. Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress[J]. Cardiovasc Res,2012,93(4):674-681.

[6]Wang X,Fang X,Zhou J,et al. Shear stress activation of nuclear receptor PXR in endothelial detoxification[J]. Proc Natl Acad Sci U S A,2013,110(32):13174-13179.

[7]Banerjee M,Robbins D,Chen T. Targeting xenobiotic receptors PXR and CAR in human diseases[J]. Drug Discov Today,2015,20(5):618-628.

[8]孙小淋,鲁敏,楚英杰. 巨噬细胞的异质性与动脉粥样硬化[J]. 中华心血管病杂志,2019,47(8):660-663.

[9]Zhou J,Zhai Y,Mu Y,et al. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway[J]. J Biol Chem,2006,281(21):15013-15020.

[10]Zhou C,King N,Chen KY,et al. Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in ApoE deficient mice[J]. J Lipid Res,2009,50(10):2004-2013.

[11]Tian K,Xu Y,Sahebkar A,et al. CD36 in atherosclerosis:pathophysiological mechanisms and therapeutic implications[J]. Curr Atheroscler Rep,2020,22(10):59.

[12]Sui Y,Xu J,Rios-Pilier J,et al. Deficiency of PXR decreases atherosclerosis in apoE-deficient mice[J]. J Lipid Res,2011,52(9):1652-1659.

[13]Sui Y,Meng Z,Park SH,et al. Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice[J]. J Lipid Res,2020,61(5):696-706.

[14]Meng Z,Gwag T,Sui Y,et al. The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling[J]. JCI Insight,2019,4(3):e125657.

[15]Gwag T,Meng Z,Sui Y,et al. Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis[J]. J Hepatol,2019,70(5):930-940.

[16]Karpale M,K?r?j?m?ki AJ,Kummu O,et al. Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism[J]. Br J Pharmacol,2021,178(12):2461-2481.

[17]Sui Y,Meng Z,Chen J,et al. Effects of dicyclohexyl phthalate exposure on PXR activation and lipid homeostasis in mice[J]. Environ Health Perspect,2021,129(12):127001.

[18]Sui Y,Park SH,Helsley RN,et al. Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice[J]. J Am Heart Assoc,2014,3(2):e000492.

[19]Sui Y,Park SH,Wang F,et al. Perinatal bisphenol A exposure increases atherosclerosis in adult male PXR-humanized mice[J]. Endocrinology,2018,159(4):1595-1608.

[20]Wu Y,Yu H,Tang HQ,et al. PXR polymorphisms have impact on the clinical efficacy of clopidogrel in patients undergoing percutaneous coronary intervention[J]. Gene,2018,653:22-28.

[21]Yang W,Yu Z,Chiyoya M,et al. Menaquinone-4 accelerates calcification of human aortic valve interstitial cells in high-phosphate medium through PXR[J]. J Pharmacol Exp Ther,2020,372(3):277-284.

[22]Zhao LY,Xu JY,Shi Z,et al. Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression[J]. Biochem Pharmacol,2017,142:194-203.

[23]Nakamura K,Moore R,Negishi M,et al. Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver[J]. J Biol Chem,2007,282(13):9768-9776.

相似文献/References:

[1]白春兰,张军.正五聚蛋白-3:新型心血管病炎性标志物[J].心血管病学进展,2016,(1):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
 BAI Chunlan,ZHANG Jun.Pentraxin-3: A Novel Inflammation Biomarker for Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2016,(6):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
[2]任茂佳,贺文帅,张琪,等.围绝经期对心血管疾病相关危险因素的影响[J].心血管病学进展,2019,(6):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
 REN Maojia,HE Wenshuai,ZHANG Qi,et al.Effects of Perimenopause on Cardiovascular Risk Factors[J].Advances in Cardiovascular Diseases,2019,(6):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
[3]尹琳 黄从新.JP2蛋白和心血管疾病的研究进展[J].心血管病学进展,2019,(7):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
 YIN Lin HUANG Congxin.Research Progress of JP2 Protein and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(6):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
[4]朱峰 汪汉 蔡琳.抗体与心血管疾病[J].心血管病学进展,2019,(7):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
 ZHU FengWANG HanCAI Lin.Antibodies and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(6):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
[5]邱明仙 王正龙 许官学.心肌肌球蛋白结合蛋白-C磷酸化与心血管疾病关系的研究进展[J].心血管病学进展,2019,(7):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
 QIU MingxianWANG ZhenglongXU Guanxue.Research Progress of the Relationship Between Cardiac Myosin Binding Protein-C and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(6):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
[6]姬楠楠 杨晓静 谢勇.单核细胞/高密度脂蛋白比值与心血管疾病的研究进展[J].心血管病学进展,2019,(7):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
 JI Nannan YANG Xiaojing XIE Yong.Monocyte/High-density Lipoprotein Ratio and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(6):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
[7]渠海贤 李涛 程流泉.人工智能在心脏磁共振成像中的应用进展[J].心血管病学进展,2019,(5):659.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.001]
[8]侯冬华 郝丽荣.长正五聚蛋白3在动脉粥样硬化和心血管疾病中作用研究的新进展[J].心血管病学进展,2019,(5):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
 HOU Donghua H AO Lirong.The Study of Atherosclerosis and Cardiovascular Diseases with Pentapycin 3[J].Advances in Cardiovascular Diseases,2019,(6):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
[9]张维 张恒 康品方.外泌体在心血管疾病中的研究进展[J].心血管病学进展,2019,(5):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
 Zhang WeiKang Pinfang.Exosome in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(6):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
[10]韦莹 刘书旺 李蕾 崔鸣.生长分化因子-15在心房颤动中的研究进展[J].心血管病学进展,2019,(8):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]
 WEI Ying,LIU Shuwang,LI Lei,et al.Growth Differentiation Factor-15 in Development of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2019,(6):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]

更新日期/Last Update: 2022-08-05