[1]叶鹏飞 郭应坤 张怡 沈梦婷 李湘 陈林 徐婷 文凌仪.动脉粥样硬化斑块磁共振成像动物模型[J].心血管病学进展,2021,(8):730-732.[doi:10.16806/j.cnki.issn.1004-3934.2021.08.014]
 YE Pengfei,GUO Yingkun,ZHANG Yi,et al.Animal Models for Magnetic Resonance Imaging of Atherosclerotic Plaque[J].Advances in Cardiovascular Diseases,2021,(8):730-732.[doi:10.16806/j.cnki.issn.1004-3934.2021.08.014]
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动脉粥样硬化斑块磁共振成像动物模型()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年8期
页码:
730-732
栏目:
综述
出版日期:
2021-08-25

文章信息/Info

Title:
Animal Models for Magnetic Resonance Imaging of Atherosclerotic Plaque
作者:
叶鹏飞1 郭应坤1 张怡2 沈梦婷2 李湘2 陈林1 徐婷1 文凌仪
(1.四川大学华西第二医院放射科,出生缺陷与相关妇儿疾病教育部重点实验室,四川 成都 6100442. 四川大学华西医院放射科,四川 成都 610041)
Author(s):
YE Pengfei1GUO Yingkun1ZHANG Yi2SHEN Mengting2LI Xiang2CHEN Lin1XU Ting1WEN Lingyi1
(1. Department of Radiology,West China Second Hospital,Sichuan University,Key Laboratory of Birth Defects and Related Diseases of Women and Children,Ministry of Education,Chengdu 610041 ,Sichuan,China2. Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China)
关键词:
动脉粥样硬化磁共振成像动物模型
Keywords:
AtherosclerosisMagnetic resonance imagingAnimal model
DOI:
10.16806/j.cnki.issn.1004-3934.2021.08.014
摘要:
动脉粥样硬化是严重威胁人体健康的心血管疾病,通过建立粥样硬化斑块动物模型,研究探索动脉粥样硬化的病理生理变化,对临床诊疗有重要价值。磁共振成像可无创评价全身大动脉粥样硬化斑块,是评价动脉粥样硬化斑块形态、成份及稳定性的有效影像技术。现将有关兔、猪及鼠动脉粥样硬化斑块动物模型的构建及磁共振成像进行综述,归纳总结不同方法的优势和劣势,为以后研究提供参考。
Abstract:
Atherosclerosis is a cardiovascular disease which seriously threatens public health. Understanding the pathophysiology of atherosclerosis by establishment of atherosclerotic plaque animal models is of great value for clinical diagnosis and treatment. Magnetic resonance imaging enables non-invasively assessing the morphology,composition and stability of atherosclerotic plaques. The construction and MRI of animal models of atherosclerotic plaques in rabbits,pigs and mice were reviewed. The advantages and disadvantages of different methods are summarized to provide references for future studies.

参考文献/References:

[1]Benjamin EJ,Muntner P,Alonso A,et al. Heart disease and stroke statistics—2019 update:a report from the American Heart Association[J]. Circulation,2019,139(10):e56-e528. [2]World Health Organization. The top 10 causes of death[EB/OL]. (2018-05-24 ). https:/ /www.who. int/news-room/fact-sheets/detail/the-top-10-causes-of-death. [3]Lee YT,Lin HY,Chan YW,et al. Mouse models of atherosclerosis:a historical perspective and recent advances[J]. Lipids Health Dis,2017,16(1):12. [4] Hossaini Nasr S,Tonson A,El-Dakdouki M,et al. Effects of nanoprobe morphology on cellular binding and inflammatory responses:hyaluronan-conjugated magnetic nanoworms for magnetic resonance imaging of atherosclerotic plaques[J]. ACS Appl Mater Interfaces,2018,10(14):11495-11507. [5]Gao Z,Ma T,Zhao E,et al. Small is smarter:nano MRI contrast agents-advantages and recent achievements[J]. Small,2016,12(5):556-576. [6]Zhao Y,Xiang L,Liu Y,et al. Atherosclerosis induced by a high-cholesterol and high-fat diet in the inbred strain of the Wuzhishan miniature pig[J]. Animal Biotechnol,2018,29(2):110-118. [7] Emini Veseli B,Perrotta P,de Meyer GRA,et al. Animal models of atherosclerosis[J]. Eur J Pharmacol,2017,816:3-13. [8]Fang B,Ren X,Wang Y,et al. Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs[J]. Dis Models Mech,2018,11(10):dmm036632. [9]Pennesi ME,Neuringer M,Courtney RJ. Animal models of age related macular degeneration[J]. Mol Aspects Med,2012,33(4):487-509. [10]Ogita M,Miyauchi K,Onishi A,et al. Development of accelerated coronary atherosclerosis model using low density lipoprotein receptor knock-out swine with balloon injury[J]. PloS One,2016,11(9):e0163055. [11] Thim T,Hagensen MK,Drouet L,et al. Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis:a model for preclinical studies[J]. EuroIntervention,2010,6(2):261-268. [12]董莉,申强,郭淼,等. 黑血动态增强磁共振成像技术对早期动脉粥样硬化炎性反应的可行性研究[J]. 心肺血管病杂志,2019,38(8):874-878. [13]Fatemeh RK,Gangadaran S,Li C,et al. Animal models of atherosclerosis[J]. World J Clin Cases,2014,2(5):126-132. [14]Masley S,Kenney JJ,Novick JS. Optimal diets to prevent heart disease[J]. JAMA,2003,289(12):1510. [15] Xu L,Wang R,Liu H,et al. Comparison of the diagnostic performances of ultrasound,high-resolution magnetic resonance imaging,and positron emission tomography/computed tomography in a rabbit carotid vulnerable plaque atherosclerosis model[J]. J Ultrasound Med,2020,39(11):2201-2209. [16]Spartalis M,Spartalis E,Athanasiou A,et al.The role of the endothelium in premature atherosclerosis:molecular mechanisms[J]. Curr Med Chem,2020,27(7):1041-1051. [17]唐曦,杨松,苟博,等. 高脂喂养联合免疫损伤建立兔动脉粥样硬化模型及评价 [J]. 中国医药导报,2016,13(18):21-24. [18]Perevozchikov AP,Vaisman BL,Sorokin AV,et al. Study of the effect of the cDNA for the human A-I gene in transgenic rabbits:modeling the neurological syndrome of human Tangier disease[J]. Mol Biol(Mosk),1993,27(1):24-37. [19]Emini Veseli B,Perrotta P,de Meyer GRA,et al. Animal models of atherosclerosis[J]. Eur J Pharmacol,2017,816:3-13. [20] Weinreb DB,Aguinaldo JG,Feig JE,et al. Non-invasive MRI of mouse models of atherosclerosis[J]. NMR Biomed,2007,20(3):256-264. [21]Hatters DM,Peters-Libeu CA,Weisgraber KH. Apolipoprotein E structure:insights into function[J]. Trends Biochem Sci,2006,31(8):445-454. [22]杨梅,周建光,曹海涛,等.实验动物动脉粥样硬化模型的建立与评价[J]. 医疗装备,2010,23(6):35-37. [23]Tani M,Matera R,Horvath KV,et al.The influence of apoE-deficiency and LDL-receptor-deficiency on the HDL subpopulation profile in mice and in humans[J]. Atherosclerosis,2014,233(1):39-44. [24]Burke AC,Huff MW. Regression of atherosclerosis:lessons learned from genetically modified mouse models[J]. Curr Opin Lipidol,2018,29(2):87-94. [25]Liao J,Liu X,Gao M,et al. Dyslipidemia,steatohepatitis and atherogenesis in lipodystrophic ApoE deficient mice with Seipin deletion[J]. Gene,2018,648:82-88. [26]孙明霞,冯越,谢敏. 靶向USPIO分子探针联合MR监测动脉粥样硬化细胞间黏附分子-1变化[J]. 心脑血管病学防治,2020,20(4),348-351. [27]Choi YJ,Jung SC,Lee DH. Vessel wall imaging of the intracranial and cervical carotid arteries[J]. J Stroke,2015,17(3):238-255. [28]Xu WH,Li ML,Niu JW,et al. Intracranial artery atherosclerosis and lumen dilation in cerebral small-vessel diseases:a high-resolution MRI Study[J]. Cns Neurosci Ther,2014,20(4):364-367. [29] Wasserman BA,Smith WI,Trout HH 3rd,et al. Carotid artery atherosclerosis:in vivo morphologic characterization with gadolinium-enhanced double-oblique MR imaging initial results[J]. Radiology,2002,223(2):566-573. [30] 徐永峰. 超高场磁共振成像射频线圈技术及实时监控系统的研究[D].中国科学技术大学,2017.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(81971586) 四川省应用基础研究项目(2019YJ0087)通信作者:文凌仪,E-mail:lizzievane@126.com 收稿日期:2020-12-26
更新日期/Last Update: 2021-09-26