[1]涂诗琴 蒲鹏 高凌云.冠心病与肠道菌群失调的关系及靶向干预机制研究进展[J].心血管病学进展,2024,(2):145.[doi:10.16806/j.cnki.issn.1004-3934.2024.02.011]
 TU Shiqin,PU Peng,GAO Lingyun.Relationship Between Coronary Heart Disease and Intestinal Flora Dysbiosis and the Mechanism of Targeted Intervention[J].Advances in Cardiovascular Diseases,2024,(2):145.[doi:10.16806/j.cnki.issn.1004-3934.2024.02.011]
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冠心病与肠道菌群失调的关系及靶向干预机制研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年2期
页码:
145
栏目:
综述
出版日期:
2024-02-25

文章信息/Info

Title:
Relationship Between Coronary Heart Disease and Intestinal Flora Dysbiosis and the Mechanism of Targeted Intervention
作者:
涂诗琴 蒲鹏 高凌云
(重庆医科大学附属第一医院心血管内科,重庆 400016)
Author(s):
TU ShiqinPU PengGAO Lingyun
(Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
关键词:
冠心病肠道菌群失调干预机制
Keywords:
Coronary heart disease Intestinal flora dysbiosis Intervention mechanisms
DOI:
10.16806/j.cnki.issn.1004-3934.2024.02.011
摘要:
冠心病是临床中发病率较高的冠状动脉粥样硬化性心脏病,近年来发病率逐年呈年轻化趋势,严重影响中国居民的生命健康。既往认为年龄、高血压、高脂血症等是冠心病发病的危险因素。近年来多项临床研究及动物模型研究证实肠道菌群失调、菌群中间代谢产物与冠心病的发生和发展存在密切关联,指出调控肠道菌群平衡可能是冠心病防治的新策略。现综述冠心病与肠道菌群失调的关系,并总结靶向肠道菌群及其代谢产物治疗冠心病的机制,以期指导冠心病的临床防治。
Abstract:
Coronary heart disease is a coronary atherosclerotic heart disease with high incidence in clinical practice,and in recent years,its incidence has been trending towards youthfulness year by year,which seriously affects the life and health of our residents. Previously,age,hypertension,hyperlipidaemia and other risk factors for the development of coronary heart disease were considered. In recent years,a number of clinical studies and animal model studies have confirmed that intestinal flora dysbiosis,intermediate metabolites of flora and the occurrence and development of coronary heart disease have a close association,suggesting that regulating the balance of intestinal flora may be a new strategy for the prevention and treatment of coronary heart disease. This article reviews the relationship between coronary heart disease and intestinal flora dysbiosis,and summarises the mechanism of targeting intestinal flora and its metabolites for the treatment of coronary heart disease,with a view to guiding the clinical prevention and treatment of coronary heart disease

参考文献/References:

[1]Ralapanawa U,Sivakanesan R. Epidemiology and the magnitude of coronary artery disease and acute coronary syndrome:a narrative review[J]. J Epidemiol Glob Health,2021,11(2):169-177.
[2]Li J,Li X,Ross JS,et al. Fibrinolytic therapy in hospitals without percutaneous coronary intervention capabilities in China from 2001 to 2011:China PEACE-retrospective AMI study [J]. Eur Heart J Acute Cardiovasc Care,2017,6(3):232-243.
[3] 卫靖靖,朱明军,王永霞,等. 心肌梗死中医健康监测的临床研究述评[J]. 中国中医基础医学杂志,2023,29(5):861-864.
[4] 复杂冠心病血运重建心脏团队决策研究协作组. 复杂冠心病血运重建策略内外科专家共识[J]. 中国循环杂志,2022,37(11):1073-1085.
[5] 北京护理学会心血管专业委员会. 冠心病患者心脏康复健康教育处方护理专家共识[J]. 中华现代护理杂志,2022,28(9):1121-1127.
[6]Bae JW,Woo SI,Lee J,et al. mHealth interventions for lifestyle and risk factor modification in coronary heart disease:randomized controlled trial[J]. JMIR Mhealth Uhealth,2021,9(9):e29928.
[7]Javdan B,Lopez JG,Chankhamjon P,et al. Personalized mapping of drug metabolism by the human gut microbiome[J]. Cell,2020,181(7):1661-1679.e22.
[8]Krautkramer KA,Fan J,B?ckhed F. Gut microbial metabolites as multi-kingdom intermediates[J]. Nat Rev Microbiol,2021,19(2):77-94.
[9]Nakajima A,Mitomo S,Yuki H,et al. Gut microbiota and coronary plaque characteristics[J]. J Am Heart Assoc,2022,11(17):e026036.
[10]Liu H,Chen X,Hu X,et al. Alterations in the gut microbiome and metabolism with coronary artery disease severity[J]. Microbiome,2019,7(1):68.
[11]Zheng X,Li J,Gou Y,et al. Changes in intestinal flora from chronic renal failure complicated with coronary heart disease and its correlation with arterial stiffness index[J]. Altern Ther Health Med,2023,29(1):252-257.
[12]Jia J,Dou P,Gao M,et al. Assessment of causal direction between gut microbiota-dependent metabolites and cardiometabolic health:a bidirectional Mendelian randomization analysis[J]. Diabetes,2019,68(9):1747-1755.
[13]Kim M,Huda MN,Bennett BJ. Sequence meets function-microbiota and cardiovascular disease[J]. Cardiovasc Res,2022,118(2):399-412.
[14]邢团结,娄焕堃,李鹏,等. 血清氧化三甲胺水平与冠心病及冠状动脉狭窄程度的相关性分析[J]. 蚌埠医学院学报,2023,48(4):466-469,473.
[15]Amrein M,Li XS,Walter J,et al. Gut microbiota-dependent metabolite trimethylamine N-oxide (TMAO) and cardiovascular risk in patients with suspected functionally relevant coronary artery disease (fCAD)[J]. Clin Res Cardiol,2022,111(6):692-704.
[16]Sardu C,Consiglia Trotta M,Santella B,et al. Microbiota thrombus colonization may influence athero-thrombosis in hyperglycemic patients with ST segment elevation myocardialinfarction(STEMI). Marianella study[J]. Diabetes Res Clin Pract,2021,173:108670.
[17]Chen W,Zhang S,Wu J,et al. Butyrate-producing bacteria and the gut-heart axis in atherosclerosis[J]. Clin Chim Acta,2020,507:236-241.
[18]Anto L,Blesso CN. Interplay between diet,the gut microbiome,and atherosclerosis:role of dysbiosis and microbial metabolites on inflammation and disordered lipid metabolism[J]. J Nutr Biochem,2022,105:108991.
[19]Luo T,Guo Z,Liu D,et al. Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3[J]. Gut Microbes,2022,14(1):2077602.
[20]陈嫚,刘洪涛,林相豪,等. 基于肠道菌群及胆汁酸代谢探讨动脉粥样硬化的发病机制[J]. 现代中西医结合杂志,2022,31(5):709-713.
[21]Sieckmann T,Kirschner KM. Polyamines,metabolites and metabolomics[J]. Acta Physiol (Oxf),2020,229(3):e13480.
[22]Lin Y,Wu SH,Wang XH,et al. Associations of imbalance of intestinal flora with severity of disease,inflammatory factors,adiponectin,and vascular endothelial function of hypertension patients[J]. Kaohsiung J Med Sci,2022,38(2):165-173.
[23]Tsutsumi R,Yamasaki Y,Takeo J,et al. Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora[J]. Transl Res,2021,237:16-30.
[24]Wang Z,Hazen J,Jia X,et al. The nutritional supplementL-alpha glycerylphosphorylcholine promotes atherosclerosis[J]. Int J Mol Sci,2021,22(24):13477.
[25]Bartolomaeus H,Balogh A,Yakoub M,et al. Short-chain fatty acid propionate protects from hypertensive cardiovascular damage[J]. Circulation,2019,139(11):1407-1421.
[26]Zhang XN,Yu ZL,Chen JY,et al. The crosstalk between NLRP3 inflammasome and gut microbiome in atherosclerosis[J]. Pharmacol Res,2022,181:106289.
[27]陈雯雯,拜年,管娜,等. 基于网络药理学和分子对接探讨黄连治疗高脂血症的作用机制[J].新疆医科大学学报,2022,45(9):1020-1028.
[28]徐卓,项想,尚尔鑫,等. 丹参茎叶总酚酸对2型糖尿病肾病小鼠肠道菌群和短链脂肪酸的调节作用[J]. 药学学报,2021,56(4):1035-1048.
[29]黄敏,杨燕.丹参酮ⅡA联合CASC2对甲状腺癌细胞增殖、凋亡、迁移、侵袭的影响[J].中国细胞生物学学报,2021,43(5):947-955.
[30]吴睿婷,付王威,万敏,等. 黑灵芝多糖对糖尿病大鼠血糖血脂调节及肠道菌群的影响[J]. 食品科学,2022,43(5):91-102.
[31]Zhang Y,Gu Y,Chen Y,et al. Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/-?mice fed with HFD[J]. J Ethnopharmacol,2021,266:113436.
[32]Li X,Liu Y,Guo X,et al. Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury[J]. Eur J Clin Nutr,2021,75(8):1227-1236.
[33]Yadav R,Khan SH,Mada SB,et al. Consumption of probiotic Lactobacillus fermentum MTCC:5898-fermented milk attenuates dyslipidemia,oxidative stress,and inflammation in male rats fed on cholesterol-enriched diet[J]. Probiotics Antimicrob Proteins,2019,11(2):509-518.
[34]Xu D,Feng M,Chu Y,et al. The prebiotic effects of oats on blood lipids ,gut microbiota,and short-chain fatty acids in mildly hypercholesterolemic subjects compared with rice:a randomized,controlled trial[J]. Front Immunol,2021,12:787797.
[35]Pathak P,Helsley RN,Brown AL,et al. Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism[J]. Am J Physiol Heart Circ Physiol,2020,318(6):H1474-H1486.
[36]Lei L,Zhao N,Zhang L,et al. Gut microbiota is a potential goalkeeper of dyslipidemia[J]. Front Endocrinol (Lausanne),2022,13:950826.
[37]Huang WC,Tung CL,Yang YSH,et al. Endurance exercise ameliorates Western diet-induced atherosclerosis through modulation of microbiota and its metabolites[J]. Sci Rep,2022,12(1):3612.
[38]Luissint AC,Williams HC,Kim W,et al. Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice[J]. Mucosal Immunol,2019,12(3):668-678.
[39]Terzo S,Mulè F,Caldara GF,et al. Pistachio consumption alleviates inflammation and improves gut microbiota composition in mice fed a high-fat diet[J]. Int J Mol Sci,2020,21(1):365.
[40]Zeng S,Yi R,Tan F,Sun P,et al. Lactobacillus plantarum?HFY05 attenuates carrageenan-induced thrombosis in mice by regulating NF-κB pathway-associated inflammatory responses[J]. Front Nutr,2022,9:813899.
[41]雍晨,黄国顺,葛宏伟,等. 中医药调节肠道菌群代谢产物氧化三甲胺干预慢性肾脏病及其并发症的研究进展[J]. 中国中药杂志,2023,48(2):321-328.
[42]Reiner MF,Müller D,Gobbato S,et al. Gut microbiota-dependent trimethylamine-N-oxide(TMAO) shows a U-shaped association with mortality but not with recurrent venous thromboembolism[J]. Thromb Res,2019,174:40-47.
[43]Vadaq N,Schirmer M,Tunjungputri RN,et al. Untargeted plasma metabolomics and gut microbiome profiling provide novel insights into the regulation of platelet reactivity in healthy individuals[J]. Thromb Haemost,2022,122(4):529-539.

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更新日期/Last Update: 2024-03-29