[1]王昱冕 陈涵 王红.生长分化因子15与心血管疾病出血事件相关性的研究进展[J].心血管病学进展,2022,(10):928.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.015]
 WANG Yumian,CHEN Han.,WANG Hong.Relationship Between Growth Differentiation Factor 15 and Cardiovascular Bleeding Events[J].Advances in Cardiovascular Diseases,2022,(10):928.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.015]
点击复制

生长分化因子15与心血管疾病出血事件相关性的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年10期
页码:
928
栏目:
综述
出版日期:
2022-10-25

文章信息/Info

Title:
Relationship Between Growth Differentiation Factor 15 and Cardiovascular Bleeding Events
作者:
王昱冕12 陈涵12 王红1
(1.昆明医科大学附属心血管病医院 云南省阜外心血管病医院心内科,云南 昆明 650102; 2.昆明医科大学研究生院,云南 昆明 650000)
Author(s):
WANG Yumian12CHEN Han1.2WANG Hong1
Department of Cardiology,Cardiovascular Hospital of Kunming Medical University,Fuwai Yunnan Cardiovascular Hospital,Kunming 650102 , YunnanChina; 2.Graduate School of Kunming Medical University,Kunming 650000,Yunnan,China)
关键词:
生长分化因子-15心血管疾病心房颤动急性冠脉综合征出血
Keywords:
Growth differentiation factor-15 Cardiovascular disease Atrial fibrillation Acute coronary syndrome Bleeding
DOI:
10.16806/j.cnki.issn.1004-3934.2022.10.015
摘要:
生长分化因子15(GDF-15)是一种应激反应蛋白,有抗炎、抗细胞凋亡、抗动脉粥样硬化和保护内皮细胞等作用;心脏手术和抗栓治疗是心血管疾病重要的治疗手段,但同时并存出血风险,如何对出血进行有效评估及预测是目前临床非常关注的问题。目前研究发现血清GDF-15增高与心脏术后及抗栓治疗的出血风险增加有关,是预测出血的较好辅助指标,尤其是纳入GDF-15水平的ABC出血评分对心房颤动抗凝出血有更高的预测价值。现就GDF-15与心血管疾病相关出血风险进行综述以期对临床提供诊疗参考。
Abstract:
Growth differentiation factor-15 (GDF-15) is a stress response protein,which has the effects of anti-inflammatory,anti-apoptosis,anti-atherosclerosis and protecting endothelial cells. Cardiac surgery and antithrombotic therapy is an important treatment for cardiovascular disease,but it also coexists with the risk of bleeding. How to effectively evaluate and predict it is a problem of great clinical concern. At present,it is found that the increase of serum GDF-15 is related to the increased risk of bleeding after cardiac surgery and antithrombotic treatment. It is a better auxiliary index to predict bleeding. In particular,ABC bleeding score included in GDF-15 level has higher predictive value for anticoagulant bleeding of atrial fibrillation. This paper reviews the relationship between GDF-15 and the risk of bleeding related to cardiovascular diseases in order to provide clinical reference for diagnosis and treatment

参考文献/References:

[1] Bootcov MR,Bauskin AR,Valenzuela SM,et al. MIC-1,a novel macrophage inhibitory cytokine,is a divergent member of the TGF-beta superfamily[J]. Proc Natl Acad Sci U S A,1997,94(21):11514-11519.

[2] Unsicker K,Spittau B,Krieglstein K. The multiple facets of the TGF-beta family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1[J]. Cytokine Growth Factor Rev,2013,24(4):373-384.

[3] B?ttner M,Laaff M,Schechinger B,et al. Characterization of the rat,mouse,and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1)[J]. Gene,1999,237(1):105-111.

[4] Patel S,Alvarez-Guaita A,Melvin A,et al. GDF15 provides an endocrine signal of nutritional stress in mice and humans[J]. Cell Metab,2019,29(3):707-718.e8.

[5] Day EA,Ford RJ,Smith BK,et al. Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss[J]. Nat Metab,2019,1(12):1202-1208.

[6] Sen T,Li J,Neuen BL,et al. Association between circulating GDF-15 and cardio-renal outcomes and effect of canagliflozin:results from the CANVAS trial[J]. J Am Heart Assoc,2021,10(23):e021661.

[7] Wallentin L,Hijazi Z,Andersson U,et al. Growth differentiation factor 15,a marker of oxidative stress and inflammation,for risk assessment in patients with atrial fibrillation:insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial[J]. Circulation,2014,130(21):1847-1858.

[8] Hylek EM,Held C,Alexander JH,et al. Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin:The ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation):Predictors,Characteristics,and Clinical Outcomes[J]. J Am Coll Cardiol,2014,63(20):2141-2147.

[9] Siegbahn A,Lindback J,Hijazi Z,et al. Multiplex protein screening of biomarkers associated with major bleeding in patients with atrial fibrillation treated with oral anticoagulation[J]. J Thromb Haemost,2021,19(11):2726-2737.

[10] Hijazi Z,Oldgren J,Andersson U,et al. Growth-differentiation factor 15 and risk of major bleeding in atrial fibrillation:Insights from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial[J]. Am Heart J,2017,190:94-103.

[11] Hijazi Z,Oldgren J,Lindb?ck J,et al. The novel biomarker-based ABC (age,biomarkers,clinical history)-bleeding risk score for patients with atrial fibrillation:a derivation and validation study[J]. Lancet,2016,387(10035):2302-2311.

[12] Berg DD,Ruff CT,Jarolim P,et al. Performance of the ABC scores for assessing the risk of stroke or systemic embolism and bleeding in patients with atrial fibrillation in ENGAGE AF-TIMI 48[J]. Circulation,2019,139(6):760-771.

[13] Benz AP,Hijazi Z,Lindb?ck J,et al. Biomarker-based risk prediction with the ABC-AF scores in patients with atrial fibrillation not receiving oral anticoagulation[J]. Circulation,2021,143(19):1863-1873.

[14] Hijazi Z,Oldgren J,Lindb?ck J,et al. Evaluation of the age,biomarkers,and clinical history-bleeding risk score in patients with atrial fibrillation with combined aspirin and anticoagulation therapy enrolled in the ARISTOTLE and RE-LY Trials[J]. JAMA Netw Open,2020,3(9):e2015943.

[15] 柯于梵,钟桃娟,萧湛潮,等. 血清生长分化因子15及ABC出血风险评分在预测老年非瓣膜病心房颤动患者口服非维生素K拮抗剂抗凝药出血风险的临床应用初探[J]. 中国动脉硬化杂志,2022,30(5):423-430.

[16] Skowrońska M,Skrzyńska M,Machowski M,et al. Plasma growth differentiation factor 15 levels for predicting serious adverse events and bleeding in acute pulmonary embolism:a prospective observational study[J]. Pol Arch Intern Med,2020,130(9):757-765.

[17] Pol T,Hijazi Z,Lindback J,et al. Evaluation of the prognostic value of GDF-15,ABC-AF-bleeding score and ABC-AF-death score in patients with atrial fibrillation across different geographical areas[J]. Open Heart,2021,8(1):e001471.

[18] Sharma A,Hijazi Z,Andersson U,et al. Use of biomarkers to predict specific causes of death in patients with atrial fibrillation[J]. Circulation,2018,138(16):1666-1676.

[19] Hagstrom E,James SK,Bertilsson M,et al. Growth differentiation factor-15 level predicts major bleeding and cardiovascular events in patients with acute coronary syndromes:results from the PLATO study[J]. Eur Heart J,2016,37(16):1325-1333.

[20] Lindholm D,Hagstrom E,James SK,et al. Growth differentiation factor 15 at 1 month after an acute coronary syndrome is associated with increased risk of major bleeding[J]. J Am Heart Assoc,2017,6(4):e005580.

[21] Lindholm D,James SK,Gabrysch K,et al. Association of multiple biomarkers with risk of all-cause and cause-specific mortality after acute coronary syndromes:a secondary analysis of the PLATO biomarker study[J]. JAMA Cardiol,2018,3(12):1160-1166.

[22] Farhan S,Freynhofer MK,Brozovic I,et al. Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study[J]. Cardiovasc Diabetol,2016,15:60.

[23] Kazem N,Hammer A,Koller L,et al. The prognostic potential of growth differentiation factor-15 on bleeding events and patient outcome after cardiac surgery-a prospective cohort study[J]. Thromb Haemost,2022,122(5):703-714.

[24] Sluka M,Hutyra M,Nykl R,et al. Risk stratification using growth differentiation factor 15 in patients undergoing transcatheter aortic valve implantation[J]. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub,2022 Apr 12.?DOI: 10.5507/bp.2022.017.?Online ahead of print.

[25] Song L,S?derholm M,Svensson EH,et al. Circulating growth differentiation factor 15 levels are associated with risk of both intracerebral and subarachnoid hemorrhage[J]. Front Neurol,2021,12:664010.

[26] Mulder FI,Boschf TM,Carrier M,et al. Growth differentiation factor-15 for prediction of bleeding in cancer patients[J]. J Thromb Haemost,2022,20(1):138-144.

[27] Ioannou A,Papageorgiou N,Falconer D,et al. Biomarkers associated with stroke risk in atrial fibrillation[J]. Curr Med Chem,2019,26(5):803-823.

[28] Wischhusen J,Melero I,Fridman WH. Growth/differentiation factor-15 (GDF-15):from biomarker to novel targetable immune checkpoint[J]. Front Immunol,2020,11:951.

[29] Eggers KM,Lindahl B. Prognostic biomarkers in acute coronary syndromes:risk stratification beyond cardiac troponins[J]. Curr Cardiol Rep,2017,19(4):29.

相似文献/References:

[1]白春兰,张军.正五聚蛋白-3:新型心血管病炎性标志物[J].心血管病学进展,2016,(1):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
 BAI Chunlan,ZHANG Jun.Pentraxin-3: A Novel Inflammation Biomarker for Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2016,(10):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
[2]任茂佳,贺文帅,张琪,等.围绝经期对心血管疾病相关危险因素的影响[J].心血管病学进展,2019,(6):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
 REN Maojia,HE Wenshuai,ZHANG Qi,et al.Effects of Perimenopause on Cardiovascular Risk Factors[J].Advances in Cardiovascular Diseases,2019,(10):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
[3]尹琳 黄从新.JP2蛋白和心血管疾病的研究进展[J].心血管病学进展,2019,(7):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
 YIN Lin HUANG Congxin.Research Progress of JP2 Protein and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(10):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
[4]朱峰 汪汉 蔡琳.抗体与心血管疾病[J].心血管病学进展,2019,(7):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
 ZHU FengWANG HanCAI Lin.Antibodies and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(10):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
[5]邱明仙 王正龙 许官学.心肌肌球蛋白结合蛋白-C磷酸化与心血管疾病关系的研究进展[J].心血管病学进展,2019,(7):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
 QIU MingxianWANG ZhenglongXU Guanxue.Research Progress of the Relationship Between Cardiac Myosin Binding Protein-C and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(10):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
[6]姬楠楠 杨晓静 谢勇.单核细胞/高密度脂蛋白比值与心血管疾病的研究进展[J].心血管病学进展,2019,(7):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
 JI Nannan YANG Xiaojing XIE Yong.Monocyte/High-density Lipoprotein Ratio and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(10):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
[7]渠海贤 李涛 程流泉.人工智能在心脏磁共振成像中的应用进展[J].心血管病学进展,2019,(5):659.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.001]
[8]侯冬华 郝丽荣.长正五聚蛋白3在动脉粥样硬化和心血管疾病中作用研究的新进展[J].心血管病学进展,2019,(5):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
 HOU Donghua H AO Lirong.The Study of Atherosclerosis and Cardiovascular Diseases with Pentapycin 3[J].Advances in Cardiovascular Diseases,2019,(10):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
[9]张维 张恒 康品方.外泌体在心血管疾病中的研究进展[J].心血管病学进展,2019,(5):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
 Zhang WeiKang Pinfang.Exosome in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(10):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
[10]李海威 姜红 李宪伦.射血分数保留性心力衰竭患者运动康复的研究进展[J].心血管病学进展,2019,(8):1146.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.019]
 LI Haiwei,JIANG Hong,LI Xianlun.Exercise Rehabilitation in Patients with Heart Failure with Preserved Ejection Fraction[J].Advances in Cardiovascular Diseases,2019,(10):1146.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.019]
[11]韦莹 刘书旺 李蕾 崔鸣.生长分化因子-15在心房颤动中的研究进展[J].心血管病学进展,2019,(8):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]
 WEI Ying,LIU Shuwang,LI Lei,et al.Growth Differentiation Factor-15 in Development of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2019,(10):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]

更新日期/Last Update: 2022-12-26