[1]邹璐蔚?#0李宗宇 刘春萍 杜晓玲 吕湛.Dickkopf家族蛋白在动脉粥样硬化发生机制中的作用[J].心血管病学进展,2022,(2):162.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.017]
 ZOU LuweiLI ZongyuLIU ChunpingDU Xiaoling.The Role of Dickkopf Family Proteins in the Mechanism of Atherosclerosis[J].Advances in Cardiovascular Diseases,2022,(2):162.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.017]
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Dickkopf家族蛋白在动脉粥样硬化发生机制中的作用()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年2期
页码:
162
栏目:
综述
出版日期:
2022-02-25

文章信息/Info

Title:
The Role of Dickkopf Family Proteins in the Mechanism of Atherosclerosis
作者:
邹璐蔚?#160李宗宇 刘春萍 杜晓玲 吕湛
(川北医学院第一附属医院,四川 南充 637000)
Author(s):
ZOU LuweiLI ZongyuLIU ChunpingDU Xiaoling
(The First Affiliated Hospital of North Sichuan Medical College,Nan Chong 637000,Sichuan,China)
关键词:
Dickkopf动脉粥样硬化Wnt/β-catenin信号通路
Keywords:
DickkopfAtherosclerosisWnt/-catenin Signaling
DOI:
10.16806/j.cnki.issn.1004-3934.2022.02.017
摘要:
Dickkopf(DKK)家族蛋白是由人体内活化的血小板和内皮细胞分泌的一种糖蛋白既往研究发现,DKK家族成员可通过多种途径参癌症、神经退行性疾病、发育缺陷、关节炎等疾病的发生发展近年有研究发现,DKK可通过影响Wnt/β-catenin通路的信号调节,参动脉血管壁的脂质浸润、炎症、血管钙化等病理过程,从而在动脉粥样硬化发生发展过程中发挥作用对DKK参动脉粥样硬化发生、发展的相关机制的研究进展一综述。
Abstract:
Dickkopf(DKK)is a glycoprotein secreted by activated platelets and endothelial cells in the human body. Previous studies have found that members of the DKK family can participate in the occurrence and development of cancerneurodegenerative diseases,developmental defects,arthritis and other diseases through a variety of pathways. Recent studies have found that DKK can regulate the signal of Wnt/β-catenin pathway,participate in lipid infiltration,inflammatory reaction,vascular calcification and other pathological processes of arterial wall,so as to play a role in the occurrence and development of atherosclerosis. This article will review the research progress of the mechanism of DKK involved in the occurrence and development of atherosclerosis

参考文献/References:

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更新日期/Last Update: 2022-08-19