[1]李嘉仪 黄龙祥 罗素新.钠-葡萄糖协同转运蛋白-2抑制剂在心血管疾病中的研究进展[J].心血管病学进展,2019,(9):1245-1249.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.015]
 LI JiayiHUANG LongxiangLUO Suxin.SGLT-2 Inhibitors in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(9):1245-1249.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.015]
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钠-葡萄糖协同转运蛋白-2抑制剂在心血管疾病中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年9期
页码:
1245-1249
栏目:
综述
出版日期:
2019-12-25

文章信息/Info

Title:
SGLT-2 Inhibitors in Cardiovascular Diseases
作者:
李嘉仪 黄龙祥12 罗素新2
(1. 重庆医科大学,重庆 400016 ;2. 重庆医科大学附属第一医院心血管内科,重庆 400016 )
Author(s):
LI Jiayi1HUANG Longxiang12LUO Suxin2
(1. Chongqing Medical University, Chongqing 400016, China; 2. Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China)
关键词:
钠-葡萄糖协同转运蛋白-2抑制剂心血管疾病2型糖尿病
Keywords:
SGLT-2 inhibitors Cardiovascular disease Type 2 diabetes
DOI:
10.16806/j.cnki.issn.1004-3934.2019.09.015
摘要:
中国目前的糖尿病患病率处在世界首位,而糖尿病常是伴随心血管疾病存在的,但传统降糖药除二甲双胍外对心血管几乎无益处,甚至还可能导致患心血管疾病的风险上升。近来受到广泛研究和关注的新型降糖药钠-葡萄糖协同转运蛋白-2抑制剂,能通过特异性地抑制肾脏重吸收葡萄糖来促进葡萄糖排泄,从而治疗2型糖尿病。此外,钠-葡萄糖协同转运蛋白-2抑制剂对于降低心力衰竭住院率和不良心血管事件的发病率、死亡率具有重要效用,现对钠-葡萄糖协同转运蛋白-2抑制剂在心血管疾病中的研究进展做一综述。
Abstract:
At present, the prevalence of diabetes mellitus is the highest in the world, and diabetes mellitus is often accompanied by cardiovascular diseases.. However, traditional glucose-lowering drugs have no cardiovascular benefits except metformin and may even increase the risk of cardiovascular disease. Recently, a new type of glucose-lowering drug, sodium-glucose cotransporter 2 inhibitors (SGLT-2 inhibitors), has been widely concerned and studied. SGLT-2 inhibitors promote the excretion of glucose by specifically inhibiting the reabsorption of glucose by the kidneys so that they could treat type 2 diabetes. Meanwhile,studies find that SGLT-2 inhibitors also have significant effects for reducing adverse cardiovascular morbidity, mortality and the hospitalization of heart failure. Therefore, this paper will review the research progress of SGLT-2 inhibitors on cardiovascular diseases

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更新日期/Last Update: 2020-02-06