[1]张聪 陈磊 杨亦奇 乔卫龙.糖蛋白乙酰与动脉粥样硬化性疾病的研究进展[J].心血管病学进展,2025,(11):1020.[doi:10.16806/j.cnki.issn.1004-3934.2025.11.013]
 ZHANG Cong,CHEN Lei,YANG Yiqi,et al.Glycoprotein Acetyls and Atherosclerotic Disease[J].Advances in Cardiovascular Diseases,2025,(11):1020.[doi:10.16806/j.cnki.issn.1004-3934.2025.11.013]
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糖蛋白乙酰与动脉粥样硬化性疾病的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年11期
页码:
1020
栏目:
综述
出版日期:
2025-11-25

文章信息/Info

Title:
Glycoprotein Acetyls and Atherosclerotic Disease
作者:
张聪1 陈磊1 杨亦奇2 乔卫龙1
(1.金堂县第二人民医院,四川 成都610404;2. 成都中医药大学,四川 成都 611137)
Author(s):
ZHANG Cong1CHEN Lei1YANG Yiqi2QIAO Weilong 1
Jintang Second Peoples Hospital,Chengdu 610404,Sichuan,China; 2.Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan,China)
关键词:
糖蛋白乙酰心血管疾病炎症预测
Keywords:
Glycoprotein acetylsCardiovascular diseaseInflammationPrediction
DOI:
10.16806/j.cnki.issn.1004-3934.2025.11.013
摘要:
糖蛋白乙酰(GlycA)是一种基于磁共振谱检测的新型炎症复合标志物,它通过整合多种急性期糖蛋白的N-乙酰葡萄糖胺信号,稳定评估全身炎症水平。相比传统标志物高敏C反应蛋白,GlycA不易受急性感染干扰,且与脂质代谢、免疫调控及动脉粥样硬化斑块不稳定存在关联。流行病学研究显示,GlycA水平升高显著增加心肌梗死、缺血性卒中及2型糖尿病等心血管事件风险,其预测能力独立于高密度脂蛋白胆固醇等传统指标,与高敏C反应蛋白具有互补性。生活方式干预(如饮食运动)可降低GlycA水平,提示其临床转化潜力。未来需统一检测标准并探索其分子机制,以实现GlycA在心血管疾病危险分层及个体化治疗中的应用。
Abstract:
Glycoprotein acetyls(GlycA),a novel composite inflammatory biomarker detected via magnetic resonance spectroscopy,stably evaluates systemic inflammation by integrating N-acetylglucosamine signals from acute-phase glycoproteins. Compared with the traditional marker high-sensitivity C-reactive protein,GlycA is less susceptible to acute infection,and is associated with lipid metabolism,immune regulation and instability of atherosclerotic plaque. Epidemiological studies show that elevated GlycA levels significantly increase the risk of cardiovascular events such as myocardial infarction,ischemic stroke,and type 2 diabetes. Its predictive ability is independent of traditional indicators such as high-density lipoprotein cholesterol,and is complementary to high-sensitivity C-reactive protein. Lifestyle interventions,such as diet and exercise,can reduce GlycA levels,indicating their potential for clinical translation. In the future,it is necessary to unify detection standards and explore their molecular mechanisms to achieve the application of GlycA in cardiovascular disease risk stratification and personalized treatment

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更新日期/Last Update: 2026-03-06