[1]雷思彤 梁靖闻 崔赫昂 缪语涵 王蕾.K63去泛素化酶在心血管疾病中的研究进展[J].心血管病学进展,2025,(12):1101.[doi:10.16806/j.cnki.issn.1004-3934.2025.12.010]
 LEI Sitong,LIANG Jingwen,CUI Heang,et al.K63 Deubiquitinases in Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2025,(12):1101.[doi:10.16806/j.cnki.issn.1004-3934.2025.12.010]
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K63去泛素化酶在心血管疾病中的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年12期
页码:
1101
栏目:
综述
出版日期:
2025-12-25

文章信息/Info

Title:
K63 Deubiquitinases in Cardiovascular Disease
作者:
雷思彤1 梁靖闻1 崔赫昂1 缪语涵1 王蕾2
(1.首都医科大学公共卫生学院,北京 100069 ;2.首都医科大学公共卫生学院营养与食品卫生系 环境与衰老北京市重点实验室,北京 100069 )
Author(s):
LEI Sitong1LIANG Jingwen1CUI Heang1MIAO Yuhan1WANG Lei2
(1.School of Public Health,Capital Medical University,Beijing 100069,China2. Department of Nutrition and Food Hygiene,School of Public Health,Capital Medical University,Key Laboratory of Cardiovascular Remodeling and Related Diseases of Ministry of Education,Beijing Key Laboratory of Environment and Aging,Beijing 100069,China)
关键词:
K63去泛素化酶心血管疾病蛋白质翻译后修饰信号转导途径
Keywords:
K63 deubiquitinase Cardiovascular disease Post-translational modification of proteins Signal transduction pathway
DOI:
10.16806/j.cnki.issn.1004-3934.2025.12.010
摘要:
K63位点特异性泛素化调控多个信号转导途径(如NF-κB、MAPK、JAK/STAT、Wnt/β-catenin),在心血管疾病的发生发展中具有关键作用。K63去泛素化酶(如A20、CYLD、USP类酶等)通过水解K63连接的泛素链,调控炎症、凋亡、纤维化等病理过程。其异常表达与心肌缺血再灌注损伤、动脉粥样硬化、心力衰竭及纤维化密切相关。现系统总结K63去泛素化酶在心血管疾病中的作用机制及靶向治疗前景,旨在为精准治疗提供新策略。
Abstract:
K63-linked ubiquitination regulates key signal transduction pathway,such as NF-κB,MAPK,JAK/STAT,and Wnt/β-catenin,playing crucial roles in cardiovascular disease. K63 deubiquitinase(including A20,CYLD,and USP families)hydrolyze K63-linked ubiquitin chains to regulate inflammation,apoptosis,and fibrosis. Their dysregulation contributes to myocardial ischemia-reperfusion injury,atherosclerosis,heart failure,and cardiac fibrosis. This review summarizes the molecular mechanisms and therapeutic potential of K63 deubiquitinase in cardiovascular disease,providing insights for targeted interventions

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更新日期/Last Update: 2026-04-14