[1]邹钰 方佳乐 王俊宏.转运RNA衍生的小RNA在心血管疾病中的研究进展[J].心血管病学进展,2025,(7):595.[doi:10.16806/j.cnki.issn.1004-3934.2025.07.004]
 ZOU Yu,FANG Jiale,WANG Junhong.Transfer RNA-Derived Small RNAs in Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2025,(7):595.[doi:10.16806/j.cnki.issn.1004-3934.2025.07.004]
点击复制

转运RNA衍生的小RNA在心血管疾病中的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年7期
页码:
595
栏目:
综述
出版日期:
2025-07-25

文章信息/Info

Title:
Transfer RNA-Derived Small RNAs in Cardiovascular Disease
作者:
邹钰 方佳乐 王俊宏
(南京医科大学第一附属医院心血管内科,江苏 南京 210029)
Author(s):
ZOU YuFANG JialeWANG Junhong
(Department of Cardiology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China.)
关键词:
转运RNA衍生的小RNA心血管疾病诊断治疗
Keywords:
Transfer RNA-derived small RNACardiovascular diseaseDiagnosisTreatment
DOI:
10.16806/j.cnki.issn.1004-3934.2025.07.004
摘要:
转运RNA衍生的小RNA(tsRNA)是一类新的非编码RNA,具有丰富的表达和较高的组织特异性,且在多种疾病的诊断和预后预测中展示了广泛的应用前景。近年来,越来越多的研究开始探讨tsRNA与心血管疾病之间的关系。现综述tsRNA的基本特征及近年来在心血管疾病中的研究进展,以期为未来的研究及临床应用提供参考。
Abstract:
Transfer RNA-derived small RNA (tsRNA) is a new class of non-coding RNAs that exhibit s abundant expression and high tissue specificity. They have shown broad potential for application in the diagnosis and prognosis of various diseases. In recent years ,an increasing number of studies have explored the relationship between tsRNA and cardiovascular disease. This review summarizes the basic characteristics of tsRNA and recent research progress in cardiovascular disease,aiming to provide insights for future research and clinical applications

参考文献/References:

[1] Chen Q,Li D,Jiang L,et al. Biological functions and clinical significance of tRNA-derived small fragment (tsRNA) in tumors:Current state and future perspectives[J]. Cancer Letters,2024,587:216701.

[2] Li J,Hou S,Ye Z,et al. Long non-coding RNAs in pancreatic cancer:biologic functions,mechanisms,and clinical significance[J]. Cancers (Basel),2022,14(9):2115.

[3] Schraivogel D,Meister G. Import routes and nuclear functions of Argonaute and other small RNA-silencing proteins[J]. Trends Biochem Sci,2014,39(9):420-431.

[4] Zhang X,Cozen AE,Liu Y,et al. Small RNA modifications:integral to function and disease[J]. Trends Mol Med,2016,22(12):1025-1034.

[5] Kumar P,Kuscu C,Dutta A. Biogenesis and function of transfer RNA-related fragments (tRFs)[J]. Trends Biochem Sci,2016,41(8):679-689.

[6] Li S,Hu GF. Emerging role of angiogenin in stress response and cell survival under adverse conditions[J]. J Cell Physiol,2012,227(7):2822-2826.

[7] Kumar P,Anaya J,Mudunuri SB,et al. Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets[J]. BMC Biol,2014,12:78.

[8] Tong L,Zhang W,Qu B,et al. The tRNA-derived fragment-3017A promotes metastasis by inhibiting NELL2 in human gastric cancer[J]. Front Oncol,2021,10:570916.

[9] Goodarzi H,Liu X,Nguyen HCB,et al. Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement[J]. Cell,2015,161(4):790-802.

[10] Lyons SM,Gudanis D,Coyne S M,et al. Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs[J]. Nat Commun,2017,8(1):1127.

[11] Shi J,Zhang Y,Zhou T,et al. tsRNAs:the Swiss army knife for translational regulation[J]. Trends Biochem Sci,2019,44(3):185-189.

[12] Dassanayaka S,Jones SP. Recent developments in heart failure[J]. Circ Res,2015,117(7):e58-63.

[13] Tanai E,Frantz S. Pathophysiology of heart failure[J]. Compr Physiol,2015,6(1):187-214.

[14] Chen Y,Tang Y,Zhu T,et al. Dynamic PAH-related changes:a dataset of tRNA-derived small RNA transcriptome across multiple organs[J]. Sci Data,2024,11(1):1257.

[15] Zhao L,Harrop DL,Ng ACT,et al. Epicardial adipose tissue is associated with left atrial dysfunction in people without obstructive coronary artery disease or atrial fibrillation[J]. Can J Cardiol,2018,34(8):1019-1025.

[16] Zhao L,Peng Y,Su P. Expression profiles and functional analysis of tRNA-derived small RNAs in epicardial adipose tissue of patients with heart failure[J]. Ann Med,55(2):2267981.

[17] Shen L,Gan M,Tan Z,et al. A novel class of tRNA-derived small non-coding RNAs respond to myocardial hypertrophy and contribute to intergenerational inheritance[J]. Biomolecules,2018,8(3):54.

[18] Xu J,Qian B,Wang F,et al. Global profile of tRNA-derived small RNAs in pathological cardiac hypertrophy plasma and identification of tRF-21-NB8PLML3E as a new hypertrophy marker[J]. Diagnostics (Basel),2023,13(12):2065.

[19] Brandhorst S,Choi I Y,Wei M,et al. A periodic diet that mimics fasting promotes multi-system regeneration,enhanced cognitive performance,and healthspan[J]. Cell Metab,2015,22(1):86-99.

[20] Liu W,Liu Y,Pan Z,et al. Systematic analysis of tRNA-derived small RNAs discloses new therapeutic targets of caloric restriction in myocardial ischemic rats[J]. Front Cell Dev Biol,2020,8:568116.

[21] Benjamin EJ,Muntner P,Alonso A,et al. Heart disease and stroke statistics-2019 update:a report from the American Heart Association[J]. Circulation,2019,139(10):e56-e528.

[22] Hao Y,Li B,Yin F,et al. tRNA-derived small RNA (tsr007330) regulates myocardial fibrosis after myocardial infarction through NAT10-mediated ac4C acetylation of EGR3 mRNA[J]. Biochim Biophys Acta Mol Basis Dis,2024,1870(6):167267.

[23] Hausenloy DJ,Yellon DM. Myocardial ischemia-reperfusion injury:a neglected therapeutic target[J]. J Clin Invest,2013,123(1):92-100.

[24] Hu K,Yan TM,Cao KY,et al. A tRNA-derived fragment of ginseng protects heart against ischemia/reperfusion injury via targeting the lncRNA MIAT/VEGFA pathway[J]. Mol Ther Nucleic Acids,2022,29:672-688.

[25] Yang ZY,Li PF,Li ZQ,et al. Altered expression of transfer-RNA-derived small RNAs in human with rheumatic heart disease[J]. Front Cardiovasc Med,2021,8:716716.

[26] Conte M,Petraglia L,Cabaro S,et al. Epicardial adipose tissue and cardiac arrhythmias:focus on atrial fibrillation[J]. Front Cardiovasc Med,2022,9:932262.

[27] Jiang F,Qin L,Wang Y,et al. Differential expression profiles and bioinformatics analysis of tRNA-derived small RNAs in epicardial fat of patients with atrial fibrillation[J]. Heliyon,2024,10(9):e30295.

[28] Xie L,Zhao Z,Xia H,et al. A novel tsRNA-5008a promotes ferroptosis in cardiomyocytes that causes atrial structural remodeling predisposed to atrial fibrillation[J]. Exp Cell Res,2024,435(2):113923.

[29] Frosteg?rd J. Immunity,atherosclerosis and cardiovascular disease[J]. BMC Med,2013,11:117.

[30] Libby P. The changing landscape of atherosclerosis[J]. Nature,2021,592(7855):524-533.

[31] Wang J,Dong PK,Xu XF,et al. Identification of tRNA-derived fragments and their potential roles in atherosclerosis[J]. Curr Med Sci,2021,41(4):712-721.

[32] He X,Yang Y,Wang Q,et al. Expression profiles and potential roles of transfer RNA-derived small RNAs in atherosclerosis[J]. J Cell Mol Med,2021,25(14):7052-7065.

[33] Hernandez R,Shi J,Liu J,et al. PANDORA-Seq unveils the hidden small noncoding RNA landscape in atherosclerosis of LDL receptor-deficient mice[J]. J Lipid Res,2023,64(4):100352.

[34] Wang J,Han B,Yi Y,et al. Expression profiles and functional analysis of plasma tRNA-derived small RNAs in children with fulminant myocarditis[J]. Epigenomics,2021,13(13):1057-1075.

[35] Yin ZQ,Han H,Yan X,et al. Research progress on the pathogenesis of aortic dissection[J]. Curr Probl Cardiol,2023,48(8):101249.

[36] Fu X,He X,Yang Y,et al. Identification of transfer RNA-derived fragments and their potential roles in aortic dissection[J]. Genomics,2021,113(5):3039-3049.

[37] Zong T,Yang Y,Lin X,et al. 5’-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection[J]. Mol Ther Nucleic Acids,2021,26:295-306.

[38] Li TX,Yang YY,Zong JB,et al. Activated neutrophil membrane-coated tRF-Gly-CCC nanoparticles for the treatment of aortic dissection/aneurysm[J]. J Control Release,2024,378:334-349.

相似文献/References:

[1]白春兰,张军.正五聚蛋白-3:新型心血管病炎性标志物[J].心血管病学进展,2016,(1):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
 BAI Chunlan,ZHANG Jun.Pentraxin-3: A Novel Inflammation Biomarker for Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2016,(7):87.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.023]
[2]任茂佳,贺文帅,张琪,等.围绝经期对心血管疾病相关危险因素的影响[J].心血管病学进展,2019,(6):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
 REN Maojia,HE Wenshuai,ZHANG Qi,et al.Effects of Perimenopause on Cardiovascular Risk Factors[J].Advances in Cardiovascular Diseases,2019,(7):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
[3]尹琳 黄从新.JP2蛋白和心血管疾病的研究进展[J].心血管病学进展,2019,(7):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
 YIN Lin HUANG Congxin.Research Progress of JP2 Protein and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(7):1004.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
[4]朱峰 汪汉 蔡琳.抗体与心血管疾病[J].心血管病学进展,2019,(7):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
 ZHU FengWANG HanCAI Lin.Antibodies and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(7):1007.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.011]
[5]邱明仙 王正龙 许官学.心肌肌球蛋白结合蛋白-C磷酸化与心血管疾病关系的研究进展[J].心血管病学进展,2019,(7):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
 QIU MingxianWANG ZhenglongXU Guanxue.Research Progress of the Relationship Between Cardiac Myosin Binding Protein-C and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(7):1015.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.013]
[6]姬楠楠 杨晓静 谢勇.单核细胞/高密度脂蛋白比值与心血管疾病的研究进展[J].心血管病学进展,2019,(7):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
 JI Nannan YANG Xiaojing XIE Yong.Monocyte/High-density Lipoprotein Ratio and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(7):1019.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.014]
[7]渠海贤 李涛 程流泉.人工智能在心脏磁共振成像中的应用进展[J].心血管病学进展,2019,(5):659.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.001]
[8]侯冬华 郝丽荣.长正五聚蛋白3在动脉粥样硬化和心血管疾病中作用研究的新进展[J].心血管病学进展,2019,(5):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
 HOU Donghua H AO Lirong.The Study of Atherosclerosis and Cardiovascular Diseases with Pentapycin 3[J].Advances in Cardiovascular Diseases,2019,(7):805.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.035]
[9]张维 张恒 康品方.外泌体在心血管疾病中的研究进展[J].心血管病学进展,2019,(5):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
 Zhang WeiKang Pinfang.Exosome in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(7):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
[10]韦莹 刘书旺 李蕾 崔鸣.生长分化因子-15在心房颤动中的研究进展[J].心血管病学进展,2019,(8):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]
 WEI Ying,LIU Shuwang,LI Lei,et al.Growth Differentiation Factor-15 in Development of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2019,(7):1073.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.001]

更新日期/Last Update: 2025-09-30