[1]张佳佳 王缚鲲.Lp-PLA2基因多态性在心血管疾病中的功能分析[J].心血管病学进展,2024,(4):359.[doi:10.16806/j.cnki.issn.1004-3934.2024.04.016]
 ZHANG Jiajia,WANG Fukun.Functional Analysis of Lp-PLA2 Gene Polymorphisms in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2024,(4):359.[doi:10.16806/j.cnki.issn.1004-3934.2024.04.016]
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Lp-PLA2基因多态性在心血管疾病中的功能分析()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年4期
页码:
359
栏目:
综述
出版日期:
2024-04-25

文章信息/Info

Title:
Functional Analysis of Lp-PLA2 Gene Polymorphisms in Cardiovascular Diseases
作者:
张佳佳 王缚鲲
(中国人民解放军联勤保障部队第九八〇医院检验科,河北 石家庄 050082)
Author(s):
ZHANG JiajiaWANG Fukun
(Laboratory Department of The 980 Hospital of The Joint Service Support Force of The Chinese People’s Liberation Army,Shijiazhuang 050082,Hebei,China)
关键词:
脂蛋白相关磷脂酶A2心血管疾病单核苷酸多态性
Keywords:
Lipoprotein-associated phospholipase A2Cardiovascular diseaseSingle nucleotide polymorphism
DOI:
10.16806/j.cnki.issn.1004-3934.2024.04.016
摘要:
心血管疾病因其流行性和高死亡率受到广泛关注。动脉粥样硬化的严重程度对心血管疾病的发展产生重要影响。脂蛋白相关磷脂酶A2(Lp-PLA2)作为血管炎症和动脉粥样硬化斑块易损性的生物标志物备受关注。在过去的20年中,人们通过基因水平对Lp-PLA2进行了大量研究,发现62%遗传因素可能影响Lp-PLA2活性变异,并且基因的多态性可能影响Lp-PLA2的功能,从而进一步影响相关疾病的进展。现探讨Lp-PLA2基因V279F、V379A、I198T、R92H的多态性与心血管疾病之间的关联性,以便更深入了解基因多态性对Lp-PLA2功能的影响。
Abstract:
Cardiovascular disease has received extensive attention due to its prevalence and high mortality. The severity of atherosclerosis has an important impact on the development of cardiovascular disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has attracted much attention as a biomarker of vascular inflammation and vulnerability to atherosclerotic plaque. In the past 20 years ,people have conducted a large number of studies on Lp-PLA2 at the gene level,and found that 62% of the genetic factors may affect the variation of Lp-PLA2 activity,and the gene polymorphism may affect the function of Lp-PLA2,thus further affecting the progress of related diseases.This article is to explore the association between Lp-PLA2 gene V279F,V379A,I198T,R92H polymorphism and cardiovascular disease ,so as to further understand the effect of gene polymorphism on Lp-PLA2 function

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更新日期/Last Update: 2024-05-31