[1]汪汉 路克宁.两样本孟德尔随机化研究应用于心血管疾病的教学与思考[J].心血管病学进展,2023,(9):849.[doi:10.16806/j.cnki.issn.1004-3934.2023.09.019]
 WANG Han,LU Kening.Two-Sample Mendelian Randomization in Teaching and Reflection on Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2023,(9):849.[doi:10.16806/j.cnki.issn.1004-3934.2023.09.019]
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两样本孟德尔随机化研究应用于心血管疾病的教学与思考()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年9期
页码:
849
栏目:
继续教育园地
出版日期:
2023-09-25

文章信息/Info

Title:
Two-Sample Mendelian Randomization in Teaching and Reflection on Cardiovascular Disease
作者:
汪汉1 路克宁2
(1成都市第三人民医院心内科,四川 成都 610031;2 南京农业大学,江苏 南京 210095)
Author(s):
WANG Han1LU Kening2
(1.Department of CardiologyThe Third Peoples Hospital of Chengdu, Chengdu 610031,Sichuan,China; 2 Nanjing Agricultural University,Nanjing 210095,Jiangsu,China)
关键词:
两样本孟德尔随机化心血管疾病教学遗传多效性
Keywords:
Two-sample Mendelian randomizationCardiovascular diseaseTeachingGenetic pleiotropy
DOI:
10.16806/j.cnki.issn.1004-3934.2023.09.019
摘要:
两样本孟德尔随机化(MR)已广泛应用于心血管疾病的研究中,但在目前的教学中,多数学生对MR的理解有限。实际上,借助两样本MR及其延伸的方法对于解构疾病、开发药物靶点极其有益。学生们应理解MR的内涵、明确结果的意义,并考虑如何处理遗传多效性问题。
Abstract:
Two-sample Mendelian randomization(MR) has been widely used in cardiovascular disease research. However,in current teaching,most students have limited understanding of MR. In fact,the use of two-sample MR and its extended methods is extremely beneficial for deconstructing diseases and developing drug targets. Students should understand the connotation of MR,clarify the significance of the results,and consider how to deal with the problem of genetic pleiotropy.

参考文献/References:

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[4] Skrivankova VW,Richmond RC,Woolf BAR,et al. Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization:The STROBE-MR Statement[J]. JAMA,2021,326(16):1614-1621.

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[8] Wang H,Luo Q,Ding X,et al. Trimethylamine N-oxide and its precursors in relation to blood pressure:a Mendelian randomization study[J]. Front Cardiovasc Med,2022,9:922441.

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更新日期/Last Update: 2023-10-17