[1]邱雪 郑静.假基因在心血管疾病中的进展[J].心血管病学进展,2020,(4):369-372.[doi:10.16806/j.cnki.issn.1004-3934.2020.04.010]
 QIU Xue,ZHENG Jing.The Role of Pseudogenes in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2020,(4):369-372.[doi:10.16806/j.cnki.issn.1004-3934.2020.04.010]
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假基因在心血管疾病中的进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年4期
页码:
369-372
栏目:
综述
出版日期:
2020-04-25

文章信息/Info

Title:
The Role of Pseudogenes in Cardiovascular Diseases
作者:
邱雪1 郑静2
(1.广西医科大学第一临床医学院,广西 南宁 530021;2. 广西医科大学第一附属医院心内科 广西心脑血管疾病防治精准医学重点实验室培育基地 广西心脑血管疾病临床医学研究中心,广西 南宁 530021)
Author(s):
QIU Xue1ZHENG Jing2
(1. The First Clinical Medical School,Guangxi Medical University,Nanning 530021,Guangxi,China2. Department of Cardiology,The First Affiliated Hospital of Guangxi Medical University,Guangxi Key Laboratory Base of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention,Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases,Nanning 530021,Guangxi,China)
关键词:
心血管疾病假基因非编码基因
Keywords:
Cardiovascular disease Pseudogenes Non-Coding genes
DOI:
10.16806/j.cnki.issn.1004-3934.2020.04.010
摘要:
心血管疾病是影响人类寿命的主要疾病,近年来随着科学技术的发展,对这一疾病的分子水平认识更为深入,有研究表明假基因参与心血管疾病的发生发展。假基因是与亲本基因高度同源的非编码基因。因无蛋白质编码功能,曾被称为“垃圾基因”,与亲本基因的高度同源性使两者难以鉴别。随着测序技术的不断发展,假基因的鉴定技术逐渐成熟,研究表明假基因与心血管疾病发生、发展密切相关。现通过综述假基因的定义、鉴定、功能及在心血管疾病的作用,加深心血管疾病研究者在这一领域的认识。
Abstract:
Cardiovascular disease is a major disease that affects human life span. In recent years,with the development of scientific research,the molecular level of this disease has been further understood,and some studies have shown that pseudogenes are involved. Pseudogenes are non-coding genes that are highly homologous with the parent genes. It has been called a "junk gene" because it has no protein-coding function,and its high homology with its parents makes it difficult to identify. With the continuous development of sequencing technology,the identification technology of pseudogenes has gradually become mature. Studies have shown that pseudogenes are closely related to the occurrence and development of cardiovascular diseases. This article reviews the definition,identification and function of pseudogenes and their role in cardiovascular disease to deepen the understanding of cardiovascular disease researchers in this field.

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备注/Memo

备注/Memo:
基金项目:广西医科大学第一临床医学院大学生科技创新训练项目(2019YFYA05)
通讯作者:郑静,E-mail:2003jing@aliyun.com
收稿日期:2019-08-27
更新日期/Last Update: 2020-07-28