[1]尹琳 黄从新.JP2蛋白和心血管疾病的研究进展[J].心血管病学进展,2019,(7):1004-1006.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
 YIN Lin HUANG Congxin.Research Progress of JP2 Protein and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(7):1004-1006.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.010]
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JP2蛋白和心血管疾病的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年7期
页码:
1004-1006
栏目:
综述
出版日期:
2019-10-25

文章信息/Info

Title:
Research Progress of JP2 Protein and Cardiovascular Disease
作者:
尹琳 黄从新
血管病研究所 心血管病湖北省重点实验室,湖北 武汉,430060)
Author(s):
YIN Lin HUANG Congxin
(Department of Cardiology, Renmin Hospital of Wuhan University/Institute of Cardiovascular Disease, Wuhan University/Hubei Key Laboratory of Cardiovascular Diseases, Wuhan 430060Hubei, China)
关键词:
心血管疾病JP2蛋白连接膜复合物
Keywords:
Cardiovascular diseaseJP2 proteinConnection membrane complex
DOI:
10.16806/j.cnki.issn.1004-3934.2019.07.010
摘要:
JP2是心肌细胞连接膜复合物的重要组成部分,不仅起到连接蛋白的作用,且参与调节多种离子通道的活性。近期研究发现JP2蛋白在多种心血管疾病中扮演着重要的角色,其过表达能维持T管空间分布的稳定性,改善心力衰竭患者的心功能,且JP2是各种原发型心肌病和心律失常的易感基因,JP2可被认为是心血管疾病潜在的重要治疗因素。
Abstract:
JP2 is an important component of the myocardial cell junction membrane complex. It not only acts as a connexin, but also participates in the regulation of the activity of various ion channels. Recent studies have found that JP2 protein plays an important role in a variety of cardiovascular diseases. overexpression JP2 can maintain the stability of the spatial distribution of T tube, improve the heart function of patients with heart failure, and JP2 is a susceptibility gene for a variety of primary cardiomyopathy and arrhythmias. Therefore, JP2 can be considered as a potentially essential therapeutic factor for cardiovascular diseases

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:中央高校基本科研业务费专项基金(2042015kf0229)收稿日期:2019-03-28
更新日期/Last Update: 2019-12-16