[1]穆耶赛尔·玉苏普 芦颜美 汤宝鹏.沙库巴曲缬沙坦对心力衰竭患者认知功能的影响[J].心血管病学进展,2023,(8):709.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.009]
 Muyassar·Yusup,LU Yanmei,TANG Baopeng.Effect of Sacubritil/Valsartan on Cognitive Function in Patients with Heart Failure[J].Advances in Cardiovascular Diseases,2023,(8):709.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.009]
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沙库巴曲缬沙坦对心力衰竭患者认知功能的影响()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年8期
页码:
709
栏目:
综述
出版日期:
2023-08-25

文章信息/Info

Title:
Effect of Sacubritil/Valsartan on Cognitive Function in Patients with Heart Failure
作者:
穆耶赛尔·玉苏普 芦颜美 汤宝鹏
(新疆医科大学第一附属医院心脏中心心脏起搏电生理科?新疆心电生理与心脏重塑重点实验室,新疆 乌鲁木齐 830000)
Author(s):
Muyassar·YusupLU YanmeiTANG Baopeng
(Department of Cardiac Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University&Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China)
关键词:
沙库巴曲缬沙坦心力衰竭认知功能障碍阿尔茨海默病
Keywords:
Sacubritil/ValsartanHeart failureCognitive dysfunction Alzheimer’s disease
DOI:
10.16806/j.cnki.issn.1004-3934.2023.08.009
摘要:
沙库巴曲缬沙坦作为结合脑啡肽酶(NEP)抑制剂和血管紧张素受体阻滞剂的双作用药物,经过多项大规模随机临床研究已广泛在慢性心力衰竭和高血压中应用。然而,NEP活性的丧失可以促进β淀粉样蛋白在大脑中的积累,而β淀粉样蛋白沉积是认知功能障碍、阿尔茨海默病的重要发生机制,这引起了众多学者对沙库巴曲缬沙坦副作用的担忧。现回顾NEP抑制剂与其认知功能关系的的相关研究,对此做一综述。
Abstract:
As a dual-acting drug binding to neprilysin (NEP) inhibitors and angiotensin receptor blockers,sacubritil/valsartan has been approved for use in chronic heart failure and hypertension after multiple large-scale randomized clinical studies and has been widely used clinically. However,the loss of NEP activity can promote the accumulation of amyloid β-protein in the brain,and amyloid β-protein deposition is an important mechanism for cognitive dysfunction and Alzheimer’s disease,which raises concerns about the side effects of sacubritil/valsartan. In this paper,the relationship between NEP inhibitors and their cognitive function is reviewed

参考文献/References:

[1] McMurray JJ,Packer M,Desai AS,et al.Angiotensin-neprilysin inhibition versus enalapril in heart failure[J].N Engl J Med,2014,371(11):993-1004.

[2] 葛均波,霍勇,杨杰孚,等.慢性心力衰竭"新四联"药物治疗临床决策路径专家共识[J].中国循环杂志,2022,37(8):769-781.

[3] Campbell DJ.Long-term neprilysin inhibition-implications for ARNIs[J].Nat Rev Cardiol,2017,14(3):171-186.

[4] Krittanawong C,Kitai T.Pharmacogenomics of angiotensin receptor/neprilysin inhibitor and its long-term side effects[J].Cardiovasc Ther,2017,35(4):e12272.

[5] Singh PK,Chen ZL,Ghosh D,et al.Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer’s patients[J].Neurobiol Dis,2020,139:104833.

[6] Mizerska-Kowalska M,Bojarska-Junak A,Jakubowicz-Gil J,et al.Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development[J].Tumour Biol,2016,37(10):13355-13368.

[7] Kaplinsky E.Sacubitril/valsartan in heart failure:latest evidence and place in therapy[J].Ther Adv Chronic Dis,2016,7(6):278-290.

[8] Nalivaeva NN,Zhuravin IA,Turner AJ.Neprilysin expression and functions in development,ageing and disease[J].Mech Ageing Dev,2020,192:111363.

[9] Chen XY,Xue Y,Chen H,et al.The globus pallidus as a target for neuropeptides and endocannabinoids participating in central activities[J].Peptides,2020,124:170210.

[10] Fischer HS,Zernig G,Schuligoi R,et al.Alterations within the endogenous opioid system in mice with targeted deletion of the neutral endopeptidase (’enkephalinase’) gene[J].Regul Pept,2000,96(1-2):53-58.

[11] Campbell DJ,Krum H,Esler MD.Losartan increases bradykinin levels in hypertensive humans[J].Circulation,2005,111(3):315-320.

[12] Zou LB,Mouri A,Iwata N,et al.Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory[J].J Pharmacol Exp Ther,2006,317(1):334-340.

[13] Hanson LR,Hafez D,Svitak AL,et al.Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice[J].J Mol Neurosci,2011,43(3):424-427.

[14] Yasojima K,Akiyama H,McGeer EG,et al.Reduced neprilysin in high plaque areas of Alzheimer brain:a possible relationship to deficient degradation of beta-amyloid peptide[J].Neurosci Lett,2001,297(2):97-100.

[15] Zhang H,Liu D,Wang Y,et al.Meta-analysis of expression and function of neprilysin in Alzheimer’s disease[J].Neurosci Lett,2017,657:69-76.

[16] Chen GF,Xu TH,Yan Y,et al.Amyloid beta: structure,biology and structure-based therapeutic development[J].Acta Pharmacol Sin,2017,38(9):1205-1235.

[17] Hafez D,Huang JY,Huynh AM,et al.Neprilysin-2 is an important β-amyloid degrading enzyme[J]. Am J Pathol,2011,178(1):306-312.

[18] Iwata N,Higuchi M,Saido TC,et al.Metabolism of amyloid-beta peptide and Alzheimer’s disease[J].Pharmacol Ther,2005,108(2):129-148.

[19] Ji B,Wang Q,Xue Q,et al.The dual role of kinin/kinin receptors system in Alzheimer’s disease[J].Front Mol Neurosci,2019,12:234.

[20] Vodovar N,Paquet C,Mebazaa A,et al.Neprilysin,cardiovascular,and Alzheimer’s diseases: the therapeutic split? [J].Eur Heart J,2015,36(15):902-905.

[21] Pardridge WM.Drug transport across the blood-brain barrie[J].J Cereb Blood Flow Metab,2012,32(11):1959-1972.

[22] Bell RD,Zlokovic BV.Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer’s disease[J].Acta Neuropathol,2009,118(1):103-113.

[23] Clifford PM,Zarrabi S,Siu G,et al.Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons[J].Brain Res,2007,1142:223-236.

[24] Langenickel TH,Tsubouchi C,Ayalasomayajula S,et al.The effect of LCZ696 (sacubitril/valsartan) on amyloid-β concentrations in cerebrospinal fluid in healthy subjects[J].Br J Clin Pharmacol,2016,81(5):878-890.

[25] Schoenfeld HA,West T,Verghese PB,et al.The effect of angiotensin receptor neprilysin inhibitor,sacubitril/valsartan,on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey[J].Toxicol Appl Pharmacol,2017,323:53-65.

[26] de Jong LW,van der Hiele K,Veer IM,et al.Strongly reduced volumes of putamen and thalamus in Alzheimer’s disease: an MRI study[J].Brain,2008,131(Pt 12):3277-3285.

[27] González-Marrero I,Giménez-Llort L,Johanson CE,et al.Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease[J].Front Cell Neurosci,2015,9:17.

[28] Balusu S,Brkic M,Libert C,et al.The choroid plexus-cerebrospinal fluid interface in Alzheimer’s disease: more than just a barrier[J].Neural Regen Res,2016,11(4):534-537.

[29] Hladky SB,Barrand MA.Elimination of substances from the brain parenchyma:efflux via perivascular pathways and via the blood-brain barrier[J].Fluids Barriers CNS,2018,15(1):30.

[30] de Vecchis R,Ariano C,di Biase G,et al.Cognitive performance of patients with chronic heart failure on sacubitril/valsartan:a?retrospective cohort study[J].Herz,2019,44(6):534-540.

[31] McMurray JJ,Packer M,Desai AS,et al.Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin‐converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM‐HF)[J].Eur J Heart Fail,2013,15(9):1062-1073.

[32] Krittanawong C,Kitai T.The head and the heart: potential long-term side effect of ARNI[J]. J Am Coll Cardiol,2017,69(14):1879-1880.

[33] Perlman A,Hirsh Raccah B,Matok I,et al.Cognition- and dementia-related adverse effects with sacubitril-valsartan:analysis of the FDA adverse event report system database[J].J Card Fail,2018,24(8):533-536.

[34] Hammadi SH,Hassan MA,Allam EA,et al.Effect of sacubitril/valsartan on cognitive impairment in colchicine-induced Alzheimer’s model in rats[J].Fundam Clin Pharmacol,2023,37(2):275-286.

[35]

McMurray JJV,Cannon JA, Quinn TJ,et al.Neprilysin inhibition does not affect cognitive function in patients with heart failure[R].Barcelona:ESC Congress,2022.

[36] Galo J,Celli D,Colombo R.Effect of sacubitril/valsartan on neurocognitive function: current status and future directions[J].Am J Cardiovasc Drugs,2021,21(3):267-270.

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更新日期/Last Update: 2023-09-21