[1]居昊 吴钢.维利西呱在心力衰竭治疗中的研究进展[J].心血管病学进展,2023,(8):713.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.010]
 JU Hao,WU Gang.Progress of Vericiguat in Treatment of Heart Failure[J].Advances in Cardiovascular Diseases,2023,(8):713.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.010]
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维利西呱在心力衰竭治疗中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年8期
页码:
713
栏目:
综述
出版日期:
2023-08-25

文章信息/Info

Title:
Progress of Vericiguat in Treatment of Heart Failure
作者:
居昊 吴钢
(武汉大学人民医院心内科,湖北 武汉 430060)
Author(s):
JU HaoWU Gang
(Department of cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China)
关键词:
维利西呱慢性心力衰竭NO-sGC-cGMP通路
Keywords:
VericiguatChronic heart failureNO-sGC-cGMP pathway
DOI:
10.16806/j.cnki.issn.1004-3934.2023.08.010
摘要:
全球现有6 000多万人罹患慢性心力衰竭,尽管针对这类患者的药物研究不断取得突破,但射血分数降低的心力衰竭患者的死亡和住院风险仍很高。在心力衰竭发生过程中,NO-sGC-cGMP通路活性降低是疾病进展的重要机制。新型药物维利西呱直接刺激可溶性鸟苷酸环化酶,修复NO-sGC-cGMP通路,从而保护心脏,改善心力衰竭患者的症状和预后。现就维利西呱的机制及目前的应用现状做一综述。
Abstract:
More than 60 million patients worldwide are surferred from chronic heart failure (CHF). Although drug research on heart failure patients has made a major breakthrough,the risk of death and hospitalization of heart failure patients with reduced ejection fraction is still high. In patients with heart failure,the activity of NO-sGC-cGMP pathway decreases,which does damage to the heart and blood vessels. The new drug called vericiguat directly stimulates sGC and repairs the NO-sGC-cGMP pathway to protect the heart and improve the symptoms and prognosis of patients with heart failure. Now,we review the mechanism and current application status of vericiguat

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更新日期/Last Update: 2023-09-21