[1]陈稳 叶强.自噬与心房颤动关系的研究进展[J].心血管病学进展,2022,(3):218-221.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
 CHEN Wen,YE Qiang.The Relationship Between Autophagy and Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2022,(3):218-221.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
点击复制

自噬与心房颤动关系的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年3期
页码:
218-221
栏目:
综述
出版日期:
2022-03-25

文章信息/Info

Title:
The Relationship Between Autophagy and Atrial Fibrillation
文章编号:
202110122
作者:
陈稳 叶强
(西南医科大学附属医院心血管内科,四川 泸州 646000)
Author(s):
CHEN WenYE Qiang
(Department of Cardiology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China)
关键词:
自噬心房颤动心房重构
Keywords:
AutophagyAtrial fibrillationAtrial remodeling
DOI:
10.16806/j.cnki.issn.1004-3934.2022.03.000
摘要:
心房颤动是临床常见心律失常,发病率高,可导致多种并发症。心房颤动的确切发生机制至今仍未完全阐明。自噬是细胞内一种进化上高度保守的特殊生理过程。在正常情况下,心肌细胞自噬维持在一个较低的水平。最新研究提示自噬在心房颤动发生及维持中起着重要作用。现就自噬在心房颤动发生、发展和维持中的作用以及机制的研究进展进行综述。
Abstract:
Atrial fibrillation is a common clinical arrhythmia with high incidence and could lead to a variety of complications. The exact mechanism of atrial fibrillation has not been fully elucidated. Autophagy is a highly evolutionarily conserved physiological process in cells. Under normal circumstances,autophagy of cardiomyocytes is maintained at a low level. Recent studies have shown that autophagy plays an important role in the occurrence and maintenance of atrial fibrillation. T he role and mechanism of autophagy in the occurrence,development and maintenance of atrial fibrillation would be reviewed i n this paper

参考文献/References:

[1]中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2020概要[J]. 中国循环杂志,2021,36(6):521-545.

[2]Nishimura T,Tooze SA. Emerging roles of ATG proteins and membrane lipids in autophagosome formation[J]. Cell Discov,2020,6(1):32.

[3]Levine B,Kroemer G. Biological functions of autophagy genes:a disease perspective[J]. Cell,2019,176(1-2):11-42.

[4]Thorburn A. Crosstalk between autophagy and apoptosis:mechanisms and therapeutic implications[J]. Prog Mol Biol Transl Sci,2020,172:55-65.

[5]Li J,Zhang D,Wiersma M,et al. Role of autophagy in proteostasis:friend and foe in cardiac diseases[J]. Cells,2018,7(12):279.

[6]Iwasaki YK,Nishida K,Kato T,et al. Atrial fibrillation pathophysiology:implications for management[J]. Circulation,2011,124(20): 2264-2274.

[7]Yue Y,Zhao J,Yan S,et al. Autophagy:a potential novel mechanistic contributor to atrial fibrillation[J]. Int J Cardiol,2014,172(2):492-494.

[8]van Bavel JJA,Vos MA,van der Heyden MAG. Cardiac arrhythmias and antiarrhythmic drugs:an autophagic perspective[J]. Front Physiol,2018,9:127.

[9]Yuan Y,Zhao J,Gong Y,et al. Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel[J]. Cell Death Dis,2018,9(9):873.

[10]Nagibin V,Egan Benova T,Viczenczova C,et al. Ageing related down-regulation of myocardial connexin-43 and up-regulation of MMP-2 may predict propensity to atrial fibrillation in experimental animals[J]. Physiol Res,2016,65 suppl 1:S91-S100.

[11]Chen Y,Qiao X,Zhang L,et al. Apelin-13 regulates angiotensin Ⅱ-induced Cx43 downregulation and autophagy via the AMPK/mTOR signaling pathway in HL-1 cells[J]. Physiol Res,2020,65(5):813-822.

[12]Xu X,Jiang R,Chen M,et al. Puerarin decreases collagen secretion in AngⅡ-induced atrial fibroblasts through inhibiting autophagy via the JNK-Akt-mTOR signaling pathway[J]. J Cardiovasc Pharmacol,2019,73(6):373-382.

[13]Ghavami S,Cunnington RH,Gupta S,et al. Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts[J]. Cell Death Dis,2015,6(3):e1696.

[14]Fu L,Wei CC,Powell PC,et al. Volume overload induces autophagic degradation of procollagen in cardiac fibroblasts[J]. J Mole Cell Cardiol,2015,89 (Pt B):241-250.

[15]Nüchel J,Ghatak S,Zuk AV,et al. TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators[J]. Autophagy,2018,14(3):465-486.

[16]Lin R,Wu S,Zhu D,et al. Osteopontin induces atrial fibrosis by activating Akt/GSK-3β/β-catenin pathway and suppressing autophagy[J]. Life Sci,2020 ,245:117328.

[17]Wiersma M,Meijering RAM,Qi XY,et al. Endoplasmic reticulum stress is associated with autophagy and cardiomyocyte remodeling in experimental and human atrial fibrillation[J]. J Am Heart Assoc,2017,6(10):e006458.

[18]Ullrich M,A?mus B,Augustin AM,et al. SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy[J]. J Mol Cell Cardiol,2019,129:13-26.

[19]Shingu Y,Takada S,Yokota T,et al. Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation[J]. P LoS One,2020,15(4):e0224713.

[20]Montaigne D,Marechal X,Lefebvre P,et al. Mitochondrial dysfunction as an arrhythmogenic substrate:a translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops[J]. J Am Coll Cardiol,2013,62(16):1466-1473.

[21]Wiersma M,van Marion DMS,Wüst RCI,et al. Mitochondrial dysfunction underlies cardiomyocyte remodeling in experimental and clinical atrial fibrillation[J]. Cells,2019,8(10),1202.

[22]Morales PE,Arias-Durán C,?valos-Guajardo Y,et al. Emerging role of mitophagy in cardiovascular physiology and pathology[J]. Mol Aspects Med,2020,71:100822.

[23]Zhou S,Dai W,Zhong G,et al. Impaired mitophagy:a new potential mechanism of human chronic atrial fibrillation[J]. Cardiol Res Pract,2020,2020:6757350.

相似文献/References:

[1]贺鹏康,周菁.心房颤动治疗新技术——冷冻球囊消融[J].心血管病学进展,2016,(1):1.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.001]
 HE Pengkang,ZHOU Jing.Cryoballoon Ablation, A Novel Technology for Atrial Fibrillation Treatment[J].Advances in Cardiovascular Diseases,2016,(3):1.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.001]
[2]都明辉,施海峰*,佟佳宾,等.心房颤动消融相关性无症状性脑缺血[J].心血管病学进展,2016,(1):3.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.002]
 DU Minghui,SHI Haifeng*,TONG Jiabin,et al.Silent Cerebral Ischemia Related to Atrial Fibrillation Ablation[J].Advances in Cardiovascular Diseases,2016,(3):3.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.002]
[3]郑环杰,综述,肖骅,等.心房颤动抗栓治疗研究进展[J].心血管病学进展,2016,(2):142.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.012]
 ZHENG Huanjie,XIAO Hua.Progress of Antithrombotic Therapy in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(3):142.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.012]
[4]张清,综述,罗素新,等.新型Xa 因子抑制剂———依度沙班在心房颤动患者抗凝治疗中的研究进展[J].心血管病学进展,2016,(2):151.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
 ZHANG Qing,LUO Suxin,TANG Jiong.Novel Factor Xa Inhibitors—Edoxaban in Prevention of Stroke in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(3):151.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
[5]胡红玲,综述,罗素新,等.预防非瓣膜性心房颤动性脑卒中的治疗新进展[J].心血管病学进展,2016,(3):250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.009]
 HU Hongling,LUO Suxin.New Progress in the Treatment for Cerebral Apoplexy of Nonvalvular Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(3):250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.009]
[6]王超,杨国澍,综述,等.关附甲素治疗心房颤动的研究进展[J].心血管病学进展,2016,(3):254.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.010]
 WANG Chao,YANG Guoshu,CAI Lin,et al.Research Progress of the Treatment of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(3):254.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.010]
[7]徐小东,综述,杨东辉,等.决奈达隆治疗心房颤动的现状及展望[J].心血管病学进展,2016,(4):368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.011]
 XU Xiaodong,YANG Donghui.Status and Prospect of Dronedarone in Treating Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(3):368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.011]
[8]张莎,储国俊,吴弘.经导管左心耳封堵术的临床应用进展[J].心血管病学进展,2015,(5):547.[doi:10.3969/j.issn.1004-3934.2015.05.006]
 ZHANG Sha,CHU Guojun,WU Hong.Clinial Application Advances in Left Atrial Appendage Closure[J].Advances in Cardiovascular Diseases,2015,(3):547.[doi:10.3969/j.issn.1004-3934.2015.05.006]
[9]汪俊,杨浩.心房颤动射频消融的术式演变[J].心血管病学进展,2015,(5):574.[doi:10.3969/j.issn.1004-3934.2015.05.013]
 WANG Jun,YANG Hao.Evolution of Radiofrequency Ablation of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2015,(3):574.[doi:10.3969/j.issn.1004-3934.2015.05.013]
[10]赵璐,苏立.心房颤动与离子通道重构研究进展[J].心血管病学进展,2015,(5):580.[doi:10.3969/j.issn.1004-3934.2015.05.014]
 ZHAO Lu,SU Li.Research Progress of Atrial Fibrillation and Ion Channel Remodeling[J].Advances in Cardiovascular Diseases,2015,(3):580.[doi:10.3969/j.issn.1004-3934.2015.05.014]
[11]韩亚凡 李耀东.内质网应激与心房颤动的研究进展[J].心血管病学进展,2023,(6):491.[doi:10.16806/j.cnki.issn.1004-3934.2023.06.003]
 HAN Yafan,LI Yaodong.Critical Role of Endoplasmic Reticulum Stress in Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2023,(3):491.[doi:10.16806/j.cnki.issn.1004-3934.2023.06.003]

更新日期/Last Update: 2022-04-20