[1]张清,综述,罗素新,等.新型Xa 因子抑制剂———依度沙班在心房颤动患者抗凝治疗中的研究进展[J].心血管病学进展,2016,(2):151-155.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
 ZHANG Qing,LUO Suxin,TANG Jiong.Novel Factor Xa Inhibitors—Edoxaban in Prevention of Stroke in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(2):151-155.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
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新型Xa 因子抑制剂———依度沙班在心房颤动患者抗凝治疗中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年2期
页码:
151-155
栏目:
综述
出版日期:
2016-04-20

文章信息/Info

Title:
Novel Factor Xa Inhibitors—Edoxaban in Prevention of Stroke in Patients with Atrial Fibrillation
作者:
张清综述罗素新1唐炯2审校
1.重庆医科大学附属第一医院心血管内科,重庆 400016; 2.成都市第三人民医院心血管内科,四川 成都 610031
Author(s):
ZHANG QingLUO Suxin1TANG Jiong2
1.Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China; 2.Department of Cardiology,The Third People's Hospital of Chengdu,Chengdu 610031,Sichuan,China
关键词:
心房颤动 脑卒中 新型口服抗凝药 Xa因子抑制剂 依度沙班
Keywords:
Atrial fibrillation Stroke prevention Novel oral anticoagulants Factor Xa inhibitors Edoxaban
分类号:
R541.7+5; R973+2
DOI:
10.16806/j.cnki.issn.1004-3934.2016.02.014
文献标志码:
A
摘要:
心房颤动是最常见的心律失常,也是缺血性卒中的主要危险因素之一。一直以来华法林都是心房颤动患者预防脑卒中和系统性血栓的一线抗凝药,但由于其治疗窗窄、药物及食物之间相互作用,需频繁监测国际标准化比值等不足,限制了其在临床上的应用。新型口服抗凝药如达比加群酯、利伐沙班和阿哌沙班目前均已上市,且广泛用于非瓣膜性心房颤动患者预防脑卒中和系统性血栓的治疗中。依度沙班是最新的用于抗凝治疗的Xa因子抑制剂,实验结果显示,依度沙班在非瓣膜性心房颤动患者预防脑卒中及系统性血栓事件上效果不亚于华法林,总的出血事件及心血管死亡事件发生率更低。现对依度沙班的临床研究及临床应用进展做一综述。
Abstract:
Atrial fibrillation is the most common arrhythmia, and patients with atrial fibrillation are susceptible to developing cardioembolic stroke.Warfarin has traditionally been used for stroke prevention.Although effective warfarin use has multiple concerns, such as a narrow therapeutic window, drug-drug and drug-food interactions and frequent need of INR monitoring.Novel oral anticoagulant agents(direct thrombin inhibitor dabigatran and factor Xa inhibitors like rivaroxaban and apixaban)have recently become available as viable alternatives for warfarin therapy.Edoxaban is the latest oral direct factor Xa inhibitor studied in the largest novel oral anticoagulant trial so far.Edoxaban was found to be non-inferior to dose-adjusted warfarin in reducing the rate of stroke and systemic embolism in patients with non-valvular atrial fibrillation, with a lower incidence of bleeding complications and cardiovascular deaths.This article reviews the clinical trials and progress of clinical application of edoxaban.

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备注/Memo

备注/Memo:
基金项目:国家重点基础研究发展计划(2014CB542400); 国家自然科学基金面上项目(81170112、81270210); 重庆市科委课题(CSTC2012jjA10143); 国家临床重点专科建设项目经费资助【财社(2011)170号】 作者简介:张清( 1990—),硕士,主要从事冠心病、心律失常、高血压临床研究。Email: 704493989@ qq. com 通信作者:罗素新,主任医师,教授,博士,硕士生导师,主要从事高血压、冠心病、心律失常、心力衰竭临床研究。Email: luosux
更新日期/Last Update: 2016-03-25