[1]范新荣,等.心房颤动药物治疗的新靶点[J].心血管病学进展,2015,(5):584-589.[doi:10.3969/j.issn.1004-3934.2015.05.015]
 FAN Xinrong,ZENG Xiaorong,et al.Novel Targets of Pharmacological Therapies at Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2015,(5):584-589.[doi:10.3969/j.issn.1004-3934.2015.05.015]
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心房颤动药物治疗的新靶点()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2015年5期
页码:
584-589
栏目:
综述
出版日期:
2016-05-20

文章信息/Info

Title:
Novel Targets of Pharmacological Therapies at Atrial Fibrillation
作者:
范新荣12曾晓荣2蔡琳1
1.成都市第三人民医院心内科 成都市心血管病研究所,四川 成都 610031; 2.泸州医学院心血管医学研究所 教育部医学电生理学重点实验室,四川 泸州 646000
Author(s):
FAN Xinrong1 2 ZENG Xiaorong 2 CAI Lin 1
1. Department of Cardiology, The Third People's Hospital of Chengdu, Chengdu Cardiovascular Disease Institute,Chengdu 610031,Sichuan,China; 2. The Institute of Cardiovascular Research, Luzhou Medical College and the Key Laboratory of Medical Electrophysio
关键词:
心房颤动 药物治疗 心房选择性 离子通道
Keywords:
atrial fibrillation pharmacological therapies atrial selectivity ion channels
分类号:
R541.7
DOI:
10.3969/j.issn.1004-3934.2015.05.015
文献标志码:
A
摘要:
心房颤动是临床上常见的,具有高发病率及病死率的一种快速性心律失常,而目前还没有安全有效的心房颤动治疗方法能完全解决这一医学难题。新近提出的心房选择性药物策略可能是心房颤动治疗新的选择。这些心房选择性药物靶点涉及多种离子通道,包括钠通道、钾通道、阳离子通道等等。这些药物作用于心房肌发挥抗心律失常作用,但极少影响心室肌,从而避免产生室性心律失常作用。现就目前已较多研究的几个心房颤动相关离子通道治疗靶点入手,详细介绍在使用或研发的药物。
Abstract:
Atrial fibrillation(AF)is the most common tachycardia and is associated with increased morbidity and mortality. Development of safe and effective treatments for AF is one of the greatest medical needs facing our society. The current atrial-selective pharmacologic strategy represents promising novel therapeutic options for the treatment of AF. The atrial-selective targets of anti-AF are involved in multiple ion channels, which include sodium channels, potassium channels and cation channels. These novel drugs possess anti-arrhythmic activity by effecting on atrium, but produce little to no effect on ventricular electrophysiologic parameters, which avoid the genesis of ventricular arrhythmia. This review focuses on several targets of anti-AF related with ion channels and new drugs on clinical practice or ongoing development.

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备注/Memo

备注/Memo:
基金项目:成都市科技局支持项目(12PPYB104SF); 四川省卫生与计划生育委员会科研项目(150016) 作者简介:范新荣(1982—),住院医师,博士,主要从事心脏电生理及心律失常机制的基础及临床研究。Email: fxr-1003@163.com 通信作者:蔡琳(1963—),主任医师,硕士,主要从事冠状动脉介入及心律失常介入治疗研究。Email: cailinwm@163.com
更新日期/Last Update: 2016-05-20