[1]吴亚希,杨丽霞.Toll样受体4与心血管疾病的研究进展[J].心血管病学进展,2016,(1):58-61.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.015]
 WU Yaxi,YANG Lixia.Research Progress of Relationship Between Toll-like Receptor 4 and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2016,(1):58-61.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.015]
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Toll样受体4与心血管疾病的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年1期
页码:
58-61
栏目:
综述
出版日期:
2016-02-20

文章信息/Info

Title:
Research Progress of Relationship Between Toll-like Receptor 4 and Cardiovascular Disease
作者:
吴亚希杨丽霞
成都军区昆明总医院心内科, 云南 昆明 650032
Author(s):
WU YaxiYANG Lixia
Department of Cardiology, Kunming General Hospital of Chengdu Military Area, Kunming 650032,Yunnan, China
关键词:
Toll样受体4 心血管疾病 炎症反应
Keywords:
Toll-like receptors Toll-like receptor 4 Cardiovascular disease
分类号:
R54
DOI:
10.16806/j.cnki.issn.1004-3934.2016.01.015
文献标志码:
A
摘要:
Toll样受体是一类表达于细胞膜上的受体家族,在先天性免疫和获得性免疫系统中,起到识别微生物的作用。Toll样受体4是最早发现的Toll样受体,在调节免疫应答、促进免疫细胞成熟分化和参与促炎因子反应中,都起到了重要作用。越来越多的研究证实,Toll样受体4作为先天性免疫的一个重要介质参与了心血管疾病的发生、发展。现主要对Toll样受体4在心血管疾病中的研究进展做一综述。
Abstract:
Toll-like receptors(TLRs),a receptor family that express on the cell membrane, relates to the immune system that recognizes microorganisms and plays a highly important role in the activation of the innate and acquired immune system. As the first discovered TLRs,TLR4 participate in pro-inflammatory response, promote the immune cells maturity and regulate the immune response. A growing body of research suggests that TLR4 is an important medium of the innate immune is involved in the occurrence and development of cardiovascular disease. This article reviews the current research on the relationship between TLR4 and cardiovascular disease.

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备注/Memo

备注/Memo:
作者简介:吴亚希(1990—),在读硕士,主要从事动脉粥样硬化研究。Email:wuyaxi015@163.com
通信作者:杨丽霞, Email:doctorlixia@aliyun.com
更新日期/Last Update: 2016-02-20