[1]陈怡彤 国伟.SHH信号通路在缺血性心脏病中的细胞特异性作用及其机制的研究进展[J].心血管病学进展,2026,(4):334.[doi:10.16806/j.cnki.issn.1004-3934.2026.04.010]
 CHEN Yitong,GUO Wei.Cell-Specific Roles and Mechanisms of the SHH Signal Pathway in Ischemic Heart Disease[J].Advances in Cardiovascular Diseases,2026,(4):334.[doi:10.16806/j.cnki.issn.1004-3934.2026.04.010]
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SHH信号通路在缺血性心脏病中的细胞特异性作用及其机制的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2026年4期
页码:
334
栏目:
综述
出版日期:
2026-04-25

文章信息/Info

Title:
Cell-Specific Roles and Mechanisms of the SHH Signal Pathway in Ischemic Heart Disease
作者:
陈怡彤1 国伟2
(1.山东第二医科大学临床医学院,山东 潍坊261000;2.济宁市第一人民医院老年医学科,山东 济宁272000)
Author(s):
CHEN Yitong1GUO Wei2
(1.School of Clinical MedicineClinical Medical College,Shandong Second Medical University ,Wei fang 261000,Shandong,China;2.Department of Geriatrics,Jining First People s Hospital,Jining 272000,Shandong,China)
关键词:
SHH信号通路缺血性心脏病氧化应激炎症细胞凋亡自噬血管再生细胞焦亡
Keywords:
SHH signal pathwayIschemic Heart DiseaseOxidative StressInflammationApoptosisAutophagyAngiogenesisPyroptosis
DOI:
10.16806/j.cnki.issn.1004-3934.2026.04.010
摘要:
SHH信号通路不仅在胚胎发育中扮演重要角色,而且还参与了多种病理生理学过程。研究发现SHH信号通路在调节心血管系统形成、组织损伤后修复和再生等环节发挥重要功能。本文从氧化应激、炎症反应、细胞凋亡、自噬、血管再生、细胞焦亡等方面,对SHH信号通路在缺血性心脏病的细胞特异性作用及其机制进行综述。
Abstract:
The SHH signal pathway not only plays an important role in embryonic development,but also participates in many physiological and pathophysiological processes,including ischemic heart disease. The SHH signal pathway plays an important role in regulating cardiovascular system formation ,cell differentiation,tissue repair after injury,and tissue regeneration. This review systematically summarizes the cell-specific roles and underlying mechanisms of the SHH signal pathway in ischemic heart disease,focusing on oxidative stress,inflammatory responses,apoptosis,autophagy,angiogenesis,and pyroptosis

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更新日期/Last Update: 2026-08-25