[1]刘瑾 郭惠杰 刘彦民 吴金春.心源性卒中的发生机制及治疗进展[J].心血管病学进展,2025,(12):1062.[doi:10.16806/j.cnki.issn.1004-3934.2025.12.002]
 LIU Jin,GUO Huijie,LIU Yanmin,et al.Mechanisms of Cardioembo lic stoke and advances in therapeutic prevention and treatment[J].Advances in Cardiovascular Diseases,2025,(12):1062.[doi:10.16806/j.cnki.issn.1004-3934.2025.12.002]
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心源性卒中的发生机制及治疗进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年12期
页码:
1062
栏目:
综述
出版日期:
2025-12-25

文章信息/Info

Title:
Mechanisms of Cardioembo lic stoke and advances in therapeutic prevention and treatment
作者:
刘瑾12 郭惠杰 12 刘彦民 2 吴金春 2
(1.青海大学,青海 西宁 810007;2.青海省人民医院心血管内科,青海 西宁 810007)
Author(s):
LIU Jin12GUO Huijie12LIU Yanmin2WU Jinchun2
?1.Qinghai University,Xining 810007,Qinghai,China2.Department of Cardiovascular Medicine,Qinghai Provincial People’s Hospital,Xining 810007,Qinghai,China)
关键词:
心源性卒中心房颤动抗凝治疗
Keywords:
Cardioembolic stokeAtrial fibrillationAnticoagulation therapy
DOI:
10.16806/j.cnki.issn.1004-3934.2025.12.002
摘要:
心源性卒中是心脏来源的栓子脱落导致脑动脉栓塞引起的缺血性卒中,其发生与心房颤动、心肌病、心脏瓣膜病、卵圆孔未闭及心脏血栓形成等有关。新近研究进一步揭示了心脏血栓的来源及血流动力学紊乱在发病中的作用。抗凝治疗是相关心源性卒中治疗的基石,血管内机械取栓显著改善了患者预后,新型口服抗凝剂的出现、左心耳封堵术的发展为心房颤动相关卒中患者提供了更多治疗选择。此外,针对栓子来源进行病因治疗进一步降低了卒中发生风险。未来研究可能聚焦于生物标志物预测及基因检测指导的个体化抗栓策略。
Abstract:
Cardioembolic stoke is an ischemic stroke caused by dislodgment of an embolus of cardiac origin leading to cerebral arterial embolism ,which has been associated with atrial fibrillation,cardiomyopathy,cardiac valvular disease,patent foramen ovale,and cardiac thrombosis. In recent years,studies have further revealed the role of cardiac thrombosis and hemodynamic disturbances in pathogenesis. Anticoagulation is the cornerstone of associated cardioembolic stoke,and endovascular mechanical thrombectomy has significantly improved the prognosis of patients ,with the advent of new oral anticoagulants and the development of left atrial appendage closure providing more options for patients with AF-related stroke. In addition,etiologic treatment targeting the source of the emboli further reduced the risk of stroke. Future studies focus on biomarker prediction and individualized antithrombotic strategies guided by genetic testing

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更新日期/Last Update: 2026-04-14