[1]郑梦 郭建强.氧化三甲胺和肾素-血管紧张素系统组分的关系在动脉粥样硬化中的作用[J].心血管病学进展,2025,(5):433.[doi:10.16806/j.cnki.issn.1004-3934.2025.05.012]
 ZHENG Meng,GUO Jianqiang.Role of Interaction Between Trimethylamine N-Oxide and Components of Renin-Angiotensin System in Development of Atherosclerosis[J].Advances in Cardiovascular Diseases,2025,(5):433.[doi:10.16806/j.cnki.issn.1004-3934.2025.05.012]
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氧化三甲胺和肾素-血管紧张素系统组分的关系在动脉粥样硬化中的作用()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年5期
页码:
433
栏目:
综述
出版日期:
2025-05-25

文章信息/Info

Title:
Role of Interaction Between Trimethylamine N-Oxide and Components of Renin-Angiotensin System in Development of Atherosclerosis
作者:
郑梦 郭建强
?内蒙古医科大学附属医院心血管内科,内蒙古 呼和浩特 010050)
Author(s):
ZHENG MengGUO Jianqiang
?Department of Cardiology,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia,China)
关键词:
氧化三甲胺动脉粥样硬化肾素-血管紧张素系统
Keywords:
Trimethylamine N- oxideAtherosclerosisRenin-angiotensin system
DOI:
10.16806/j.cnki.issn.1004-3934.2025.05.012
摘要:
氧化三甲胺(TMAO)是肠道菌群的代谢产物。既往研究显示TMAO在动脉粥样硬化的病理过程中发挥重要作用。TMAO参与动脉粥样硬化的病理机制主要包括参与内皮功能障碍、促进泡沫细胞形成和血栓形成。近年来,研究发现TMAO与肾素-血管紧张素系统有一定的关联。TMAO可能通过调控血管紧张素Ⅱ和血管紧张素Ⅱ1型受体的表达,激活血管紧张素Ⅱ1型受体下游信号通路,加重动脉粥样硬化的病变。现围绕TMAO促进动脉粥样硬化病理过程的机制进行综述,并提出TMAO与肾素-血管紧张素系统的相关性这一新角度,以期为心血管疾病的防治提供新方法。
Abstract:
Trimethylamine N-oxide (TMAO) is a metabolite of intestinal flora. Previous studies have shown that TMAO plays an important role in the pathologic process of atherosclerosis. The pathological mechanisms of TMAO involved in atherosclerosis mainly include participation in endothelial dysfunction,promotion of foam cell formation and thrombosis. Recently,it has been found that TMAO is associated with the renin-angiotensin system.TMAO may exacerbate the lesions of atherosclerosis by regulating the expression of angiotensinⅡand angiotensinⅡtype 1 receptor and activating the angiotensinⅡtype 1 receptor downstream signaling pathway. This review aims to provide a comprehensive overview of the mechanisms by which TMAO facilitates atherosclerosis ,while introducing a novel perspective on the potential interaction between TMAO and renin-angiotensin system pathway and providing new approaches for the prevention and treatment of atherosclerosis.

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