[1]桂琳 董睿 吴雪莲 王黔艳 何艳 尹虹.补体C1q/肿瘤坏死因子相关蛋白家族在动脉粥样硬化中的作用[J].心血管病学进展,2024,(6):552.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.017]
 GUI Lin,DONG Rui,WU Xuelian,et al.Role of the Complement C1q/Tumour Necrosis Factor-Related Protein Family in Atherosclerosis[J].Advances in Cardiovascular Diseases,2024,(6):552.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.017]
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补体C1q/肿瘤坏死因子相关蛋白家族在动脉粥样硬化中的作用()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年6期
页码:
552
栏目:
综述
出版日期:
2024-06-25

文章信息/Info

Title:
Role of the Complement C1q/Tumour Necrosis Factor-Related Protein Family in Atherosclerosis
作者:
桂琳1 董睿2 吴雪莲1 王黔艳1 何艳1 尹虹1
(1.华中科技大学同济医学院附属梨园医院心血管中心,湖北 武汉 430077;2.华中科技大学同济医学院附属梨园医院呼吸内科,湖北 武汉 430077)
Author(s):
GUI Lin1 DONG Rui2 WU Xuelian1 WANG Qianyan1 HE Yan1 YIN Hong1
Cardiovascular Center, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 4300 77, Hubei, China2 Department of Respiratory Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, Hubei, China)
关键词:
C1q/肿瘤坏死因子相关蛋白冠心病动脉粥样硬化
Keywords:
C1q/tumor necrosis factor-related proteinCoronary heart diseaseAtherosclerosis
DOI:
10.16806/j.cnki.issn.1004-3934.2024.06.017
摘要:
补体C1q/肿瘤坏死因子相关蛋白(CTRP)是高度保守的脂联素旁系同源物,具有与脂联素相似的结构及功能。动脉粥样硬化是冠心病的主要病理表现,CTRP家族在动脉粥样硬化、缺血性心肌病、高血压等心血管疾病中作用广泛。大量的研究数据表明补体CTRP家族中,补体CTRP1、CTRP5促进动脉粥样硬化的发展,补体CTRP3、CTRP6、CTRP9、CTRP12、CTRP13、CTRP15可抑制动脉粥样硬化的进程。现综述CTRP在动脉粥样硬化中作用的最新进展。
Abstract:
Complement C1q/tumor necrosis factor-related protein(CTRP) is a highly conserved lipocalin paralog with similar structure and function as lipocalin. Atherosclerosis is the main pathological manifestation of coronary heart disease. CTRP family plays wide-ranging roles in cardiovascular diseases, such as atherosclerosis, ischemic cardiomyopathy, and hypertension. Numerous studies have shown that among the complement CTRP family, complement CTRP1 and CTRP5 promote the development of atherosclerosis, and complement CTRP3, CTRP 6, CTRP9, CTRP12, CTRP13, and CTRP15 inhibit atherosclerotic progression. This article reviews recent advances on the role in atherosclerosis

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更新日期/Last Update: 2024-07-26