[1]喜林强 孙华鑫 商鲁翔 汤宝鹏 周贤惠.心房能量代谢重塑和PPARγ靶向干预在心房颤动中的研究进展[J].心血管病学进展,2023,(10):926.[doi:10.16806/j.cnki.issn.1004-3934.2023.10.014]
 XI Linqiang,SUN Huaxin,SHANG Luxiang,et al.Atrial Energy Metabolism Remodeling and Targeted Intervention of PPAR in Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2023,(10):926.[doi:10.16806/j.cnki.issn.1004-3934.2023.10.014]
点击复制

心房能量代谢重塑和PPARγ靶向干预在心房颤动中的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年10期
页码:
926
栏目:
综述
出版日期:
2023-10-25

文章信息/Info

Title:
Atrial Energy Metabolism Remodeling and Targeted Intervention of PPAR in Atrial Fibrillation
作者:
喜林强 孙华鑫 商鲁翔 汤宝鹏 周贤惠
(新疆医科大学第一附属医院心脏起搏与电生理科/新疆心电生理与心脏重塑重点实验室,新疆 乌鲁木齐 830054)
Author(s):
XI LinqiangSUN HuaxinSHANG LuxiangTANG BaopengZHOU Xianhui
(Cardiac Pacing and Electrophysiology/Department of Cardiac Electrophysiology and Remodeling,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)
关键词:
心房颤动心肌能量代谢过氧化物酶体增殖物激活受体线粒体吡格列酮
Keywords:
Atrial fibrillationMyocardial energy metabolismPeroxisome proliferator-activated receptorMitochondriaPioglitazone
DOI:
10.16806/j.cnki.issn.1004-3934.2023.10.014
摘要:
心房颤动(房颤)是临床常见的心律失常,具有高死亡率和致残。心房重塑(电、结构重塑)与房颤发病密切相关。成熟心肌细胞向胎儿表型的转换、线粒体功能障碍和活性氧过载的细胞效应等生物学事件参与心房重塑。过氧化物酶体增殖物激活受体γ(PPARγ)是心肌细胞能量代谢调控的关键开关。对房颤能量重塑、心房肌细胞代谢紊乱调控机制的研究,特别是针对PPARγ介导的糖脂代谢表型转换的干预,可能成为房颤治疗的新策略。
Abstract:
Atrial fibrillation is a common arrhythmia with high mortality and disability.Atrial remodeling (electrical,structural and neural) is closely related to the pathogenesis of atrial fibrillation.Biological events such as the transition of mature cardiomyocytes to fetal phenotype,mitochondrial dysfunction and cellular effects of reactive oxygen species overload are involved in atrial remodeling.Peroxisome proliferator-activated receptor(PPARγ) is a key switch in the regulation of energy metabolism in cardiomyocytes.The studies on the regulation mechanism of atrial fibrillation energy remodeling and atrial myocyte metabolic disorder,especially the intervention of glucose and lipid metabolism phenotype switching mediated by PPARγ,may become a new strategy for the treatment of atrial fibrillation

参考文献/References:

[1].Essien UR,Kornej J,Johnson AE,et al.Social determinants of atrial fibrillation [J].Nat Rev Cardiol,2021,18(11):763-773.
[2].Du X,Guo L,Xia S,et al.Atrial fibrillation prevalence,awareness and management in a nationwide survey of adults in China[J].Heart,2021,107(7):535-541.
[3].Burdett P,Lip GYH.Atrial fibrillation in the UK:predicting costs of an emerging epidemic recognizing and forecasting the cost drivers of atrial fibrillation-related costs[J].Eur Heart J Qual Care Clin Outcomes,2022,8(2):187-194.
[4].Wijesurendra RS,Casadei B.Mechanisms of atrial fibrillation[J].Heart,2019,105(24):1860-1867.
[5].Xia W,Li X,Wu Q,et al. The importance of caveolin as a target in the prevention and treatment of diabetic cardiomyopathy[J]. Front Immunol,2022,13:951381.
[6].Chen YC,Voskoboinik A,Gerche A,et al.Prevention of pathological atrial remodeling and atrial fibrillation:JACC state-of-the-art review [J].J Am Coll Cardiol,2021,77(22):2846-2864.
[7].Tribulova N,Egan Benova T,Szeiffova Bacova B,et al.New aspects of pathogenesis of atrial fibrillation: remodelling of intercalated discs[J].J Physiol Pharmacol,2015,66(5):625-634.
[8].Landstrom AP,Dobrev D,Wehrens XHT.Calcium signaling and cardiac arrhythmias[J].Circ Res,2017,120(12):1969-1993.
[9].Heijman J,Muna AP,Veleva T,et al.Atrial myocyte NLRP3/CaMKII Nexus forms a substrate for postoperative atrial fibrillation [J].Circ Res,2020,127(8):1036-1055.
[10].Zhou B,Caudal A,Tang X,et al.Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts [J].J Clin Invest,2022,132(10):e155333.
[11].Guan D,Xiong Y,Borck PC,et al.Diet-induced circadian enhancer remodeling synchronizes opposing hepatic lipid metabolic processes [J].Cell,2018,174(4):831-842.e12.
[12].Emelyanova L,Ashary Z,Cosic M,et al.Selective downregulation of mitochondrial electron transport chain activity and increased oxidative stress in human atrial fibrillation [J].Am J Physiol Heart Circ Physiol,2016,311(1):H54-63.
[13].Davogustto G,Dillon W,Salazar R,et al. The Warburg effect in the heart:increased glucose metabolism drives car-diomyocyte hypertrophy in response to adrenergic stimulation[J]. J Am Coll Cardiol,2018,71(11):A802-812.14.
[14].Hu HJ,Zhang C,Tang ZH,et al. Regulating the Warburg effect on metabolic stress and myocardial fibrosis remodeling and atrial intracardiac waveform activity induced by atrial fibrillation[J].Biochem Biophys Res Commun,2019,516(3):653-660.
[15].Garbincius JF,Elrod JW.Mitochondrial calcium exchange in physiology and disease[J].Physiol Rev,2022,102(2):893-992.
[16].Kummer E,Ban N.Mechanisms and regulation of protein synthesis in mitochondria[J].Nat Rev Mol Cell Biol,2021,22(5):307-325.
[17].Wiersma M,van Marion DMS,Wüst RCI,et al.Mitochondrial dysfunction underlies cardiomyocyte remodeling in experimental and clinical atrial fibrillation [J].Cells,2019,8(10):1202.
[18].Foster MN,Coetzee WA.KATP channels in the cardiovascular system [J] .Physiol Rev,2016,96(1):177-252.
[19].Brown SM,Larsen NK,Thankam FG,et al.Fetal cardiomyocyte phenotype ,ketone body metabolism,and mitochondrial dysfunction in the pathology of atrial fibrillation[J].Mol Cell Biochem,2021,476(2):1165-1178.
[20].Zhang D,Wu CT,Qi X,et al. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation [J].Circulation,2014,129(3):346-358.
[21].Boyman L,Karbowski M,Lederer WJ.Regulation of mitochondrial ATP production:Ca2+ signaling and quality control [J].Trends Mol Med,2020,26(1):21-39.
[22].Montaigne D,Butruille L,Staels B.PPAR control of metabolism and cardiovascular functions[J].Nat Rev Cardiol,2021,18(12):809-823.
[23].Pol CJ,Lieu M,Drosatos K.PPARs: protectors or opponents of myocardial function?[J].PPAR Res,2015,2015:835985.
[24].Legchenko E,Chouvarine P,Borchert P,et al.PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation [J].Sci Transl Med,2018,10(438):eaao0303.
[25].Yan XL,Wang YY,Yu ZF,et al. Peroxisome proliferator-activated receptor-gamma activation attenuates diabetic cardiomyopathy via regulation of the TGF-β/ERK pathway and epithelial-to-mesenchymal transition [J].Life Sci,2018,213:269-278.
[26].Taylor CT,Scholz CC.The effect of HIF on metabolism and immunity[J].Nat Rev Nephrol,2022,18(9):573-587.
[27].Ambrose LJA,Abd-Jamil AH,Gomes RSM,et al.Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms of regulation [J].J Cardiovasc Pharmacol Ther,2014,19(6):574-585.
[28].Suffee N,Baptista E,Piquereau J,et al. Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice [J].Cardiovasc Res,2022,118(15):3126-3139.
[29].Lim SA,Moon Y,Shin MH,et al.Hypoxia-driven HIF-1α activation reprograms pre-activated NK cells towards highly potent effector phenotypes via ERK/STAT3 pathways [J].Cancers (Basel),2021,13(8):1904.
[30].Krishnan J,Suter M,Windak R,et al.Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy [J].Cell Metab,2009,9(6):512-524.
[31].Liu Y,Zhang Q,Yang L,et al.Viametformin attenuates cardiac hypertrophy the HIF-1α/PPAR-γ signaling pathway in high-fat diet rats[J].Front Pharmacol,2022,13:919202.
[32].Ban JJ,Ruthenborg RJ,Cho KW,et al.Regulation of obesity and insulin resistance by hypoxia-inducible factors [J].Hypoxia (Auckl),2014,2:171-183.
[33].Hoong CWS,Chua MWJ.SGLT2 inhibitors as calorie restriction mimetics:insights on longevity pathways and age-related diseases[J].Endocrinology,2021,162(8):bqab079.
[34].Liao Hung-Wei,Saver Jeffrey L,Wu Yi-Ling et al. Pioglitazone and cardiovascular outcomes in patients with insulin resistance, pre-diabetes and type 2 diabetes: a systematic review and meta-analysis.[J] .BMJ Open, 2017, 7: e013927.
[35].Zhang Z,Zhang X,Meng L,et al.Pioglitazone inhibits diabetes-induced atrial mitochondrial oxidative stress and improves mitochondrial biogenesis ,dynamics,and function through the PPAR-γ/PGC-1α signaling pathway[J].Front Pharmacol,2021,12:658362.
[36].Zhang Zhiwei,Zhang Xiaowei,Korantzopoulos Panagiotis et al. Thiazolidinedione use and atrial fibrillation in diabetic patients: a meta-analysis.[J] .BMC Cardiovasc Disord, 2017, 17: 96.
[37].Liu C,Liu R,Fu H,et al.Pioglitazone attenuates atrial remodeling and vulnerability to atrial fibrillation in alloxan-induced diabetic rabbits [J].Cardiovasc Ther,2017,35(5).DOI:10.1111/1755-5922.12284.
[38].Ploeg MC,Munts C,Prinzen FW,et al.Piezo1 mechanosensitive ion channel mediates stretch-induced Nppb expression in adult rat cardiac fibroblasts [J].Cells,2021,10(7):1745.
[39].Fernandez-Boyanapalli RF,Frasch SC,Thomas SM,et al.Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease[J].J Allergy Clin Immunol,2015,135(2):517-527.e12.

相似文献/References:

[1]贺鹏康,周菁.心房颤动治疗新技术——冷冻球囊消融[J].心血管病学进展,2016,(1):1.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.001]
 HE Pengkang,ZHOU Jing.Cryoballoon Ablation, A Novel Technology for Atrial Fibrillation Treatment[J].Advances in Cardiovascular Diseases,2016,(10):1.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.001]
[2]都明辉,施海峰*,佟佳宾,等.心房颤动消融相关性无症状性脑缺血[J].心血管病学进展,2016,(1):3.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.002]
 DU Minghui,SHI Haifeng*,TONG Jiabin,et al.Silent Cerebral Ischemia Related to Atrial Fibrillation Ablation[J].Advances in Cardiovascular Diseases,2016,(10):3.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.002]
[3]郑环杰,综述,肖骅,等.心房颤动抗栓治疗研究进展[J].心血管病学进展,2016,(2):142.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.012]
 ZHENG Huanjie,XIAO Hua.Progress of Antithrombotic Therapy in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):142.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.012]
[4]张清,综述,罗素新,等.新型Xa 因子抑制剂———依度沙班在心房颤动患者抗凝治疗中的研究进展[J].心血管病学进展,2016,(2):151.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
 ZHANG Qing,LUO Suxin,TANG Jiong.Novel Factor Xa Inhibitors—Edoxaban in Prevention of Stroke in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):151.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
[5]胡红玲,综述,罗素新,等.预防非瓣膜性心房颤动性脑卒中的治疗新进展[J].心血管病学进展,2016,(3):250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.009]
 HU Hongling,LUO Suxin.New Progress in the Treatment for Cerebral Apoplexy of Nonvalvular Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.009]
[6]王超,杨国澍,综述,等.关附甲素治疗心房颤动的研究进展[J].心血管病学进展,2016,(3):254.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.010]
 WANG Chao,YANG Guoshu,CAI Lin,et al.Research Progress of the Treatment of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):254.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.010]
[7]徐小东,综述,杨东辉,等.决奈达隆治疗心房颤动的现状及展望[J].心血管病学进展,2016,(4):368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.011]
 XU Xiaodong,YANG Donghui.Status and Prospect of Dronedarone in Treating Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.011]
[8]张莎,储国俊,吴弘.经导管左心耳封堵术的临床应用进展[J].心血管病学进展,2015,(5):547.[doi:10.3969/j.issn.1004-3934.2015.05.006]
 ZHANG Sha,CHU Guojun,WU Hong.Clinial Application Advances in Left Atrial Appendage Closure[J].Advances in Cardiovascular Diseases,2015,(10):547.[doi:10.3969/j.issn.1004-3934.2015.05.006]
[9]汪俊,杨浩.心房颤动射频消融的术式演变[J].心血管病学进展,2015,(5):574.[doi:10.3969/j.issn.1004-3934.2015.05.013]
 WANG Jun,YANG Hao.Evolution of Radiofrequency Ablation of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2015,(10):574.[doi:10.3969/j.issn.1004-3934.2015.05.013]
[10]赵璐,苏立.心房颤动与离子通道重构研究进展[J].心血管病学进展,2015,(5):580.[doi:10.3969/j.issn.1004-3934.2015.05.014]
 ZHAO Lu,SU Li.Research Progress of Atrial Fibrillation and Ion Channel Remodeling[J].Advances in Cardiovascular Diseases,2015,(10):580.[doi:10.3969/j.issn.1004-3934.2015.05.014]

更新日期/Last Update: 2023-11-15