[1]郭良 黄鹤.恶性肿瘤相关心房颤动发病机制的研究进展[J].心血管病学进展,2022,(10):870.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.002]
 GUO LiangHUANG He.Pathogenesis of Malignant Tumor-Related Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2022,(10):870.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.002]
点击复制

恶性肿瘤相关心房颤动发病机制的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年10期
页码:
870
栏目:
综述
出版日期:
2022-10-25

文章信息/Info

Title:
Pathogenesis of Malignant Tumor-Related Atrial Fibrillation
作者:
郭良 黄鹤
(武汉大学人民医院心内科 心血管病湖北省重点实验室,湖北 武汉 430060)
Author(s):
GUO LiangHUANG He
(Department of Cardiology, Renmin Hospital of Wuhan University,.Hubei Key Laboratory of Cardiology, Wuchang 430060,Wuhan, China)
关键词:
心房颤动恶性肿瘤肺癌食管癌乳腺癌慢性淋巴细胞性白血病术后心房颤动
Keywords:
Atrial fibrillation Malignant tumor Lung cancer Esophagus cancer Breast cancer Chronic lymphocytic leukemia Postoperative atrial fibrillation
DOI:
10.16806/j.cnki.issn.1004-3934.2022.10.002
摘要:
恶性肿瘤相关心房颤动的发病率高,症状明显,整体预后差,发病机制尚不明确。目前有部分研究已经阐述了一些不同的发病机制,然而,不同的恶性肿瘤合并心房颤动的发生机制不同,尽可能多地了解恶性肿瘤患者心律失常的触发和维持机制,为建立预防措施和有针对性的有效治疗很重要。
Abstract:
The incidence of malignant tumor-related atrial fibrillation is high, the symptoms are obvious , the overall prognosis is poor , and the pathogenesis is not clear. At present, some studies have elucidated some different pathogenesis. However , different malignant tumors with atrial fibrillation have different mechanisms. It is important to understand as much as possible the triggering and maintenance mechanisms of arrhythmia in patients with malignant tumors for the establishment of preventive measures and targeted effective treatment.

参考文献/References:




[1] Shi S,Tang Y,Zhao Q,et al. Prevalence and risk of atrial fibrillation in China:a national cross-sectional epidemiological study[J]. Lancet Reg Health West Pac,2022,23:100439

[2] Hajjar LA,Fonseca SMR,Machado TIV. Atrial fibrillation and cancer[J]. Front Cardiovasc Med,2021,8:590768.

[3] Fitzpatrick T,Carrier M,Le Gal G. Cancer,atrial fibrillation,and stroke[J]. Thromb Res,2017,155:101-105.

[4] Chu G,Versteeg HH,Verschoor AJ,et al. Atrial fibrillation and cancer—An unexplored field in cardiovascular oncology[J]. Blood Rev,2019,35:59-67.

[5] Vedovati MC,Giustozzi M,Verdecchia P,et al. Patients with cancer and atrial fibrillation treated with doacs: A prospective cohort study[J]. Int J Cardiol,2018,269:152-157.

[6] Chebbout R,Heywood EG,Drake TM,et al. A systematic review of the incidence of and risk factors for postoperative atrial fibrillation following general surgery[J]. Anaesthesia,2018,73(4):490-498.

[7] Farmakis D,Parissis J,Filippatos G. Insights into onco-cardiology: atrial fibrillation in cancer[J]. J Am Coll Cardiol,2014,63(10):945-953.

[8] Chen PS,Tan AY. Autonomic nerve activity and atrial fibrillation[J]. Heart Rhythm,2007,4(3 Suppl):S61-S64.

[9] Yalcin MU,Gurses KM,Kocyigit D,et al. Elevated M2-muscarinic and β1-adrenergic receptor autoantibody levels are associated with paroxysmal atrial fibrillation[J]. Clin Res Cardiol,2015,104(3):226-233.

[10] Yalcin MU,Gurses KM,Kocyigit D,et al. Cardiac autoantibody levels predict recurrence following cryoballoon-based pulmonary vein isolation in paroxysmal atrial fibrillation patients[J]. J Cardiovasc Electrophysiol,2015,26(6):615-621.

[11] Gurses KM,Yalcin MU,Kocyigit D,et al. M2-muscarinic acetylcholine receptor autoantibody levels predict left atrial fibrosis severity in paroxysmal lone atrial fibrillation patients undergoing cryoablation[J]. Europace,2015,17(2):239-246.

[12] Wickramasinghe SR,Patel VV. Local innervation and atrial fibrillation[J]. Circulation,2013,128(14):1566-1575.

[13] Dobrev D,Aguilar M,Heijman J,et al. Postoperative atrial fibrillation: mechanisms,manifestations and management[J]. Nat Rev Cardiol,2019,16(7):417-436.

[14] Bessissow A,Khan J,Devereaux PJ,et al. Postoperative atrial fibrillation in non-cardiac and cardiac surgery: an overview[J]. J Thromb Haemost,2015,13(Suppl 1):S304-S312.

[15] Bruins P,te Velthuis H,Yazdanbakhsh AP,et al. Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia[J]. Circulation,1997,96(10):3542-3548.

[16] Hak ?,My?liwska J,Wieckiewicz J,et al. Interleukin-2 as a predictor of early postoperative atrial fibrillation after cardiopulmonary bypass graft (CABG) [J] . J Interferon Cytokine Res,2009,29(6):327-332.

[17] Barnes WS. Depressing effects of calcium antagonists on oxygen consumption in isolated skeletal muscle during potassium depolarization[J]. Can J Physiol Pharmacol,1988,66(6):836-840.

[18] Stoppe C,Rex S,Goetzenich A,et al. Interaction of MIF family proteins in myocardial ischemia/reperfusion damage and their influence on clinical outcome of cardiac surgery patients[J]. Antioxid Redox Signal,2015,23(11):865-879.

[19] Hu YF,Chen YJ,Lin YJ,et al. Inflammation and the pathogenesis of atrial fibrillation[J]. Nat Rev Cardiol,2015,12(4):230-243.

[20] Heerdt PM,Kant R,Hu Z,et al. Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy[J]. J Mol Cell Cardiol,2012,53(3):350-353.

[21] Lohani KR,Nandipati KC,Rollins SE,et al. Transthoracic approach is associated with increased incidence of atrial fibrillation after esophageal resection[J]. Surg Endosc,2015,29(7):2039-2045.

[22] Ma JY,Wang Y,Zhao YF,et al. Atrial fibrillation after surgery for esophageal carcinoma: clinical and prognostic significance[J]. World J Gastroenterol,2006,12(3):449-452.

[23] Wu JH,Marchioli R,Silletta MG,et al. Oxidative stress biomarkers and incidence of postoperative atrial fibrillation in the omega-3 fatty acids for prevention of postoperative atrial fibrillation (OPERA) trial[J]. J Am Heart Assoc,2015,4(5):e001886.

[24] Sovari AA,Dudley SC. Antioxidant therapy for atrial fibrillation:lost in translation?[J]. Heart,2012,98(22):1615- 1616.

[25] Briones AM,Touyz RM. Oxidative stress and hypertension:current concepts[J]. Curr Hypertens Rep,2010,12(2):135-142.

[26] Grieve DJ,Shah AM. Oxidative stress in heart failure. More than just damage[J]. Eur Heart J,2003,24(24):2161-2163.

[27] Fukunaga N,Takahashi N,Hagiwara S,et al. Establishment of a model of atrial fibrillation associated with chronic kidney disease in rats and the role of oxidative stress[J]. Heart Rhythm,2012,9(12):2023-2031.

[28] Li Y,Sheng L,Li W,et al. Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs[J]. Biochem Biophys Res Commun,2009,381(2):198-203.

[29] Wu JH,Lemaitre RN,King IB,et al. Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study[J]. Circulation,2012,125(9):1084-1093.

[30] Leitinger N,Huber J,Rizza C,et al. The isoprostane 8-iso-PGF(2alpha) stimulates endothelial cells to bind monocytes:differences from thromboxane-mediated endothelial activation[J]. FASEB J,2001,15(7):1254-1256.

[31] Huber J,Bochkov VN,Binder BR,et al. The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways[J]. Antioxid Redox Signal,2003,5(2):163-169.

[32] Sardar P,Kundu A,Chatterjee S,et al. Transcatheter versus surgical aortic valve replacement in intermediate-risk patients:evidence from a meta-analysis[J]. Catheter Cardiovasc Interv,2017,90(3):504-515.

[33] Ai D,Lasala J,Mehran JR,et al. Preoperative echocardiographic parameters of diastolic dysfunction did not provide a predictive value for postoperative atrial fibrillation in lung and esophageal cancer surgery[J]. J Cardiothorac Vasc Anesth,2015,29(5):1127-1130.

[34] Amar D,Zhang H,Shi W,et al. Brain natriuretic peptide and risk of atrial fibrillation after thoracic surgery[J]. J Thorac Cardiovasc Surg,2012,144(5):1249-1253.

[35] Nojiri T,Maeda H,Takeuchi Y,et al. Predictive value of B-type natriuretic peptide for postoperative atrial fibrillation following pulmonary resection for lung cancer[J]. Eur J Cardiothorac Surg,2010,37(4):787-791.

[36] Gibson PH,Croal BL,Cuthbertson BH,et sl. Use of preoperative natriuretic peptides and echocardiographic parameters in predicting new-onset atrial fibrillation after coronary artery bypass grafting: a prospective comparative study[J]. Am Heart J,2009,158(2):244-251.

[37] Amar D,Burt ME,Bains MS,et al. Symptomatic tachydysrhythmias after esophagectomy:incidence and outcome measures[J]. Ann Thorac Surg,1996,61(5):1506-1509.

[38] Stephens DM,Byrd JC. How I manage ibrutinib intolerance and complications in patients with chronic lymphocytic leukemia[J].Blood,2019,133(12):1298-1307.

[39] Tuomi JM,Xenocostas A,Jones DL. Increased susceptibility for atrial and ventricular cardiac arrhythmias in mice treated with a single high dose of ibrutinib[J]. Can J Cardiol,2018,34(3):337-341.

[40] McMullen JR,Boey EJ,Ooi JY,et al. Ibrutinib increases the risk of atrial fibrillation,potentially through inhibition of cardiac PI3K-Akt signaling[J]. Blood,2014,124(25):3829-3830.

[41] Pretorius L,Du XJ,Woodcock EA,et al. Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation[J]. Am J Pathol,2009,175(3):998-1009.

[42] Alexandre J,Moslehi JJ,Bersell KR,et al. Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms[J]. Pharmacol Ther,2018,189:89-103.

[43] Qureshi WT,O’Neal WT,Khodneva Y,et al. Association between opioid use and atrial fibrillation: the reasons for geographic and racial differences in stroke (REGARDS) study[J]. JAMA Intern Med,2015,175(6):1058-1060.

[44] Lendeckel U,Müller C,R?cken C,et al. Expression of opioid receptor subtypes and their ligands in fibrillating human atria[J]. Pacing Clin Electrophysiol,2005,28(suppl 1):S275-S279.

[45] Al-Hasani R,Bruchas MR. Molecular mechanisms of opioid receptor-dependent signaling and behavior[J]. Anesthesiology,2011,115(6):1363-1381.

[46] Wang SY,Long JB,Hurria A,et al. Cardiovascular events,early discontinuation of trastuzumab, and their impact on survival[J]. Breast Cancer Res Treat,2014,146(2):411-419.

[47] Chen J,Long J,Hurria A,et al. Early termination of adjuvant trastuzumab associated with cardiovascular events in older women with breast cancer[J]. Circulation,2012,126(21): A18979.

[48] Lampson BL,Yu L,Glynn RJ,et al. Ventricular arrhythmias and sudden death in patients taking ibrutinib[J]. Blood,2017,129(18):2581-2584.

[49] ElZarrad MK,Mukhopadhyay P,Mohan N,et al. Trastuzumab alters the expression of genes essential for cardiac function and induces ultrastructural changes of cardiomyocytes in mice[J]. PLoS One,2013,8(11):e79543.

相似文献/References:

[1]贺鹏康,周菁.心房颤动治疗新技术——冷冻球囊消融[J].心血管病学进展,2016,(1):1.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.001]
 HE Pengkang,ZHOU Jing.Cryoballoon Ablation, A Novel Technology for Atrial Fibrillation Treatment[J].Advances in Cardiovascular Diseases,2016,(10):1.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.001]
[2]都明辉,施海峰*,佟佳宾,等.心房颤动消融相关性无症状性脑缺血[J].心血管病学进展,2016,(1):3.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.002]
 DU Minghui,SHI Haifeng*,TONG Jiabin,et al.Silent Cerebral Ischemia Related to Atrial Fibrillation Ablation[J].Advances in Cardiovascular Diseases,2016,(10):3.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.002]
[3]郑环杰,综述,肖骅,等.心房颤动抗栓治疗研究进展[J].心血管病学进展,2016,(2):142.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.012]
 ZHENG Huanjie,XIAO Hua.Progress of Antithrombotic Therapy in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):142.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.012]
[4]张清,综述,罗素新,等.新型Xa 因子抑制剂———依度沙班在心房颤动患者抗凝治疗中的研究进展[J].心血管病学进展,2016,(2):151.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
 ZHANG Qing,LUO Suxin,TANG Jiong.Novel Factor Xa Inhibitors—Edoxaban in Prevention of Stroke in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):151.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
[5]胡红玲,综述,罗素新,等.预防非瓣膜性心房颤动性脑卒中的治疗新进展[J].心血管病学进展,2016,(3):250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.009]
 HU Hongling,LUO Suxin.New Progress in the Treatment for Cerebral Apoplexy of Nonvalvular Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.009]
[6]王超,杨国澍,综述,等.关附甲素治疗心房颤动的研究进展[J].心血管病学进展,2016,(3):254.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.010]
 WANG Chao,YANG Guoshu,CAI Lin,et al.Research Progress of the Treatment of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):254.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.010]
[7]徐小东,综述,杨东辉,等.决奈达隆治疗心房颤动的现状及展望[J].心血管病学进展,2016,(4):368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.011]
 XU Xiaodong,YANG Donghui.Status and Prospect of Dronedarone in Treating Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(10):368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.011]
[8]张莎,储国俊,吴弘.经导管左心耳封堵术的临床应用进展[J].心血管病学进展,2015,(5):547.[doi:10.3969/j.issn.1004-3934.2015.05.006]
 ZHANG Sha,CHU Guojun,WU Hong.Clinial Application Advances in Left Atrial Appendage Closure[J].Advances in Cardiovascular Diseases,2015,(10):547.[doi:10.3969/j.issn.1004-3934.2015.05.006]
[9]汪俊,杨浩.心房颤动射频消融的术式演变[J].心血管病学进展,2015,(5):574.[doi:10.3969/j.issn.1004-3934.2015.05.013]
 WANG Jun,YANG Hao.Evolution of Radiofrequency Ablation of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2015,(10):574.[doi:10.3969/j.issn.1004-3934.2015.05.013]
[10]赵璐,苏立.心房颤动与离子通道重构研究进展[J].心血管病学进展,2015,(5):580.[doi:10.3969/j.issn.1004-3934.2015.05.014]
 ZHAO Lu,SU Li.Research Progress of Atrial Fibrillation and Ion Channel Remodeling[J].Advances in Cardiovascular Diseases,2015,(10):580.[doi:10.3969/j.issn.1004-3934.2015.05.014]

更新日期/Last Update: 2022-12-26