[1]王猛 江洪.肠道菌群及其代谢产物与心房颤动的研究进展[J].心血管病学进展,2022,(3):214-217.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
 WANG Meng,JIANG Hong.Gut Microbiota an d Its Metabolites in Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2022,(3):214-217.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
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肠道菌群及其代谢产物与心房颤动的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年3期
页码:
214-217
栏目:
综述
出版日期:
2022-03-25

文章信息/Info

Title:
Gut Microbiota an d Its Metabolites in Atrial Fibrillation
文章编号:
202111095
作者:
王猛 江洪
(武汉大学人民医院心内科 武汉大学自主神经研究中心 心血管病湖北省重点实验室,湖北 武汉 430060)
Author(s):
WANG MengJIANG Hong
(Department of Cardiology,Renmin Hospital of Wuhan University/Autonomic Nervous Research Center,Wuhan University,Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)
关键词:
肠道菌群心房颤动氧化三甲胺脂多糖
Keywords:
Gut microbiotaAtrial fibrillationTrimethylamine oxideLipopolysaccharide
DOI:
10.16806/j.cnki.issn.1004-3934.2022.03.000
摘要:
心房颤动(房颤)是临床常见的心律失常之一,随年龄的增长,其发病率显著增加。而房颤控制不佳易导致卒中、心力衰竭和死亡等并发症的发生风险增加。因此,明确房颤的发生机制及关键危险因素对于防治房颤的发生具有重要意义。近年来,研究发现肠道菌群及其代谢产物氧化三甲胺、脂多糖、短链脂肪酸等能通过影响机体炎症反应、心房电重构及心房纤维化等过程,促进房颤的发生和发展。现对肠道微生物及其代谢产物在房颤中作用的最新研究进展进行综述。
Abstract:
Atrial fibrillation is common arrhythmia in clinical practice,and its incidence rate increases significantly with age. Poor control of atrial fibrillation tends to increase the risk of stroke,heart failure and death. In recent years,studies have found that gut microbiota and its metabolites,trimethylamine oxide,lipopolysaccharide and short-chain fatty acids,can promote the occurrence and development of atrial fibrillation by affecting the body’s inflammatory response,atrial electrical remodeling and atrial fibrosis. We will review the latest studies about the role of gut microbiota and its metabolites in atrial fibrillation.

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更新日期/Last Update: 2022-04-20