[1]王丁坤 李卫萍.正五聚蛋白3在冠心病中的研究进展[J].心血管病学进展,2021,(11):968-972.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
 WANG Dingkun,LI Weiping.Pentraxin 3 in Coronary Atherosclerotic Heart Disease[J].Advances in Cardiovascular Diseases,2021,(11):968-972.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
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正五聚蛋白3在冠心病中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年11期
页码:
968-972
栏目:
综述
出版日期:
2021-11-25

文章信息/Info

Title:
Pentraxin 3 in Coronary Atherosclerotic Heart Disease
文章编号:
202105112
作者:
王丁坤 李卫萍
坤 李卫萍 (首都医科大学附属北京友谊医院心内科,北京100050)
Author(s):
WANG DingkunLI Weiping
(Department of Cardiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)
关键词:
正五聚蛋白3冠心病炎症
Keywords:
Pentraxin 3Coronary atherosclerotic heart diseaseInflammation
DOI:
10.16806/j.cnki.issn.1004-3934.2021.11.000
摘要:
正五聚蛋白3(PTX3)是一种新型的炎症急性期反应蛋白,在炎症因子和外源微生物 的刺激下由多种细胞快速产生,通过与补体、核因子κB和P选择素等相互作用,调节病毒、细菌和真菌感染引发的天然免疫,同时可抑制癌症进程并促进组织修复。近年很多基础和临床研究显示,PTX3在动脉粥样硬化的发生和发展、斑块稳定性及血栓形成过程中发挥重要作用,可作为心血管不良事件的预测因子。现针对PTX3在冠心病中的研究进展进行简要概述。
Abstract:
Pentraxin 3(PTX3) is a new type of acute phase inflammatory response protein,which can be rapidly produced by various cells in response to inflammatory cytokines and exogenous microorganisms. Through interacting with complement,nuclear factor-κB and P-selectin, PTX3 regulates the natural immunity caused by virus,bacterial and fungal infection,inhibits the process of cancer and promotes tissue repair. Recent basic and clinical studies have shown that PTX3 plays an important role in the occurrence and development of atherosclerosis,plaque stability and thrombosis,and can be used as a predictor of adverse cardiovascular events. This article briefly summarizes the recent research progress of PTX3 in coronary atherosclerotic heart disease.

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更新日期/Last Update: 2021-12-06