[1]王梓良 何一秀 林伟力 张再磊 褚银平.单纯左心耳干预预防心源性脑卒中的研究进展[J].心血管病学进展,2021,(11):1007-1011.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
　WANG ZiliangHE YixiuLIN WeiliZHANG ZaileiCHU Yinping.Prevention of Cardiogenic Stroke by Simple Intervention of Left Atrial Appendage[J].Advances in Cardiovascular Diseases,2021,(11):1007-1011.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
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单纯左心耳干预预防心源性脑卒中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年11期
页码:
1007-1011
栏目:
综述
出版日期:
2021-11-25

文章信息/Info

Title:
Prevention of Cardiogenic Stroke by Simple Intervention of Left Atrial Appendage
文章编号:
202105041
作者:
王梓良1 何一秀2 林伟力1 张再磊1 褚银平1
(1.山西医科大学第五临床医学院,山西 太原 030001;2.杭州师范大学附属医院,浙江 杭州 310000)
Author(s):
WANG Ziliang1HE Yixiu2LIN Weili1ZHANG Zailei1CHU Yinping1
(1.The Fifth Clinical Medical College of Shanxi Medical UniversityTaiyuan 030001ShanxiChina2.The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310000ZhejiangChina)
关键词:
心房颤动; 血栓栓塞; 左心耳夹闭术; 心源性脑卒中
Keywords:
Atrial fibrillation; Thromboembolism; Left atrial appendage clipping; Cardiogenic stroke
DOI:
10.16806/j.cnki.issn.1004-3934.2021.11.000
摘要:
心房颤动（Af）是临床上最常见的心律失常之一，其引起的血栓栓塞常见且危害极大。单纯处理Af无法完全避免血栓栓塞的发生，需针对血栓的形成进行治疗。传统预防血栓栓塞主要依靠口服抗栓药物，但口服抗栓药物多具有出血风险、用药禁忌和患者依从性差等不足，通常不能完全达到Af抗凝的预期效果。随解剖及病理学研究的深入，现已证实血栓主要形成于Af患者的左心耳（LAA），因此可通过闭合LAA来预防血栓栓塞。内科经皮LAA封堵术因其器械相关血栓，并发症严重等劣势而难以推广使用。传统外科手术切除LAA成功率低，风险大，并发症多，所以无法作为首选治疗方式。LAA夹闭术以其微创、手术成功率高和并发症少等优势，在预防Af患者血栓栓塞中的作用日益被关注。现就LAA夹闭术的有效性、安全性、耐久性和存在的争议等方面进行综述。
Abstract:
Atrial fibrillation is one of the most common arrhythmias i n clinic,and thromboembolism caused by atrial fibrillation is common and harmful. The treatment of atrial fibrillation alone cannot completely avoid the occurrence of thromboembolism,so it is necessary to treat the formation of thrombus. The traditional prevention of thromboembolism mainly depends on oral antithrombotic drugs,but oral antithrombotic drugs often have shortcomings such as bleeding risk,medication contraindication and poor patient compliance,which usually can not fully achieve the expected effect of atrial fibrillation anticoagulation. With the development of anatomical and pathological research,it has been proved that thrombosis is mainly formed in the left atrial appendage（LAA） of atrial fibrillation patients. Therefore,thrombosis can be prevented by closing the LAA.?Internal medicine percutaneous LAA occlusion is difficult to be popularized because of its equipment related thrombosis and serious complications. Traditional surgical resection of LAA has low success rate,high risk and many complications,so it can not be used as the first choice of treatment.?LAA clipping has attracted more and more attention in the prevention of thromboembolism in atrial fibrillation patients for its advantages of minimally invasive,high success rate and less complications. This paper reviews the effectiveness,safety,durability and controversy of LAA clipping.

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更新日期/Last Update: 2021-12-06