[1]施国荣 刘婷婷 田欣 祝自新 郑文荣 王宇峰 孙芳玲 王文.Eph/ephrin信号通路在缺血性心脏病中血管生成中的研究进展[J].心血管病学进展,2021,(2):158.[doi:10.16806/j.cnki.issn.1004-3934.2021.02.016]
 Shi Guorong,Liu Tingting,Tian Xin,et al.Research Progress of Eph/ephrin Signaling Pathway in Angiogenesis of Ischemic Heart Disease[J].Advances in Cardiovascular Diseases,2021,(2):158.[doi:10.16806/j.cnki.issn.1004-3934.2021.02.016]
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Eph/ephrin信号通路在缺血性心脏病中血管生成中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年2期
页码:
158
栏目:
综述
出版日期:
2021-02-25

文章信息/Info

Title:
Research Progress of Eph/ephrin Signaling Pathway in Angiogenesis of Ischemic Heart Disease
作者:
施国荣 刘婷婷 田欣 祝自新 郑文荣 王宇峰 孙芳玲 王文
 (北京市老年病医疗研究中心,首都医科大学宣武医院实验动物室,北京 100053)
Author(s):
Shi GuorongLiu TingtingTian XinZhu ZixinZhen WenrongWang YufengSun FanglingWang Wen
 (Beijing Geriatrics Medical Research Center,Xuanwu Hospital Animal LaboratoryCapital Medical University ,Beijing 100053,China)
关键词:
缺血性心脏病Eph/ephrin信号通路血管再生
Keywords:
Ischemic heart diseaseEph/ephrin pathwayRegeneration of vascular
DOI:
10.16806/j.cnki.issn.1004-3934.2021.02.016
摘要:
缺血性心脏病主要是粥样硬化病变导致冠状动脉梗阻进而引起心肌缺血后的左心室发生一系列病变问题,在中老年人群中的发病率和死亡率逐年增高。Eph/ephrin信号对心脏发育及血管生成等过程具有重要的作用,很可能作为心脏功能调控的关键途径。现对Eph/ephrin信号通路在血管发育及再生中的作用机制的研究进展进行综述,以期为缺血性心脏病的有效治疗提供参考。
Abstract:
Ischemic heart disease is mainly caused by atherosclerotic lesions, which leads to coronary artery obstruction,and a series of pathological changes of left ventricle. The morbidity and mortality of myocardial ischemia in middle-aged population are rapidly increasing year by year. Since Eph/ephrin signaling pathway is essential for heart development and vessels formation,it might play an important role in heart function recovery. This paper reviews the research progesses of Eph/ephrin pathway in the development and regeneration of vascular,to provide an insight into the treatment of ischemic heart disease

参考文献/References:

[1]Gurunathan A,Ricci K,Iacobas I,et al. Impact of vascular anomalies on the PTEN phenotype in children and young adults[J]. Pediatr Blood Cancer,2020,67(6):e28258.

[2]Niethamer TK,Bush JO. Getting direction(s):the Eph/ephrin signaling system in cell positioning[J]. Dev Biol,2019,447(1):42-57.

[3]Su SA,Xie Y,Zhang Y,et al. Essential roles of EphrinB2 in mammalian heart:from development to diseases[J]. Cell Commun Signal,2019,17(1):29.

[4]Yang D,Jin C,Ma H,et al. EphrinB2/EphB4 pathway in postnatal angiogenesis:a potential therapeutic target for ischemic cardiovascular disease[J].Angiogenesis, 2016,19(3):297-309.

[5]Tsakiroglou P,VandenAkker NE,Del Bo’C,et al. Role of berry anthocyanins and phenolic acids on cell migration and angiogenesis:an updated overview[J]. Nutrients,2019,11(5):1075.

[6]Luxán G,Stewen J,Díaz N,et al. Endothelial EphB4 maintains vascular integrity and transport function in adult heart[J]. Elife,2019,8:e45863.

[7]Chen K,Bai H,Liu Y,et al. EphB4 forward-signaling regulates cardiac progenitor development in mouse ES cells[J]. J Cell Biochem,2015,116(3):467-475.

[8]Park I,Lee HS. EphB/ephrinB signaling in cell adhesion and migration[J]. Mol Cells,2015,38(1):14-19.

[9]Gucciardo E,Sugiyama N,Lehti K. Eph- and ephrin -dependent mechanisms in tumor and stem cell dynamics[J]. Cell Mol Life Sci,2014,71(19):3685-3710.

[10]Pitulescu ME,Schmidt I,Giaimo BD,et al. Dll4 and Notch signalling couples sprouting angiogenesis and artery formation[J]. Nat Cell Biol,2017,19(8):915-927.

[11]Yuan C,Wang P,Zhu S,et al. Overexpression of ephrinB2 in stem cells from apical papilla accelerates angiogenesis[J]. Oral Dis,2019,25(3):848-859.

[12]Cao C,Huang Y,Tang Q,et al. Bidirectional juxtacrine ephrinB2/Ephs signaling promotes angiogenesis of ECs and maintains self-renewal of MSCs[J]. Biomaterials, 2018,172:1-13.

[13]Ho VC,Fong GH. Vasculogenesis and angiogenesis in VEGF receptor-1 deficient mice[J]. Methods Mol Biol,2015,1332:161-176.

[14]Groppa E,Brkic S,Uccelli A,et al. EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF[J]. EMBO Rep,2018,19(5):e45054.

[15]Gong T,Xu J,Heng B,et al. EphrinB2/EphB4 signaling regulates DPSCs to induce sprouting angiogenesis of endothelial cells[J]. J Dent Res,2019,98(7):803-812.

[16]Chen D,Teng JM,North PE,et al. RASA1-dependent cellular export of collagen Ⅳ controls blood and lymphatic vascular development[J]. J Clin Invest, 2019,129(9):3545-3561.

[17]Xiao H,Huang Q,Wang JQ,et al. Effect of ephrin-B2 on the expressions of angiopoietin-1 and -2 after focal cerebral ischemia/reperfusion[J]. Neural Regen Res,2016,11(11):1784-1789.

[18]Buckens OJ,El Hassouni B,Giovannetti E,et al. The role of Eph receptors in cancer and how to target them:novel approaches in cancer treatment[J]. Expert Opin Investig Drugs,2020,29(6):567-582.

[19]Cheng N,Brantley DM,Liu H,et al. Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis[J]. Mol Cancer Res,2002,1(1):2-11.

[20]Torres MJ,McLaughlin KL,Renegar RH,et al. Intracardiac administration of ephrinA1-Fc preserves mitochondrial bioenergetics during acute ischemia/reperfusion injury[J]. Life Sci,2019,239:117053.

[21]Le MNT,Hasegawa K. Expansion culture of human pluripotent stem cells and production of cardiomyocytes[J]. Bioengineering (Basel),2019,6(2):48.

[22]Kemmerling N,Wunderlich P,Theil S,et al. Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia[J]. Glia,2017,65(7):1103-1118.

[23]Barquilla A,Pasquale EB. Eph receptors and ephrins:therapeutic opportunities[J]. Annu Rev Pharmacol Toxicol,2015,55:465-487.

[24]Protack CD,Foster TR,Hashimoto T,et al. Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency[J]. Sci Rep,2017,7(1):15386.

[25]Zheng LC,Wang XQ,Lu K,et al. Ephrin-B2/Fc promotes proliferation and migration, and suppresses apoptosis in human umbilical vein endothelial cells[J]. Oncotarget, 2017,8(25):41348-41363.

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更新日期/Last Update: 2021-06-16