[1]唐超 蔡琳 张艺文 汪汉.基于网络药理学的血必清注射液治疗新型冠状病毒感染合并心肌炎的作用机制研究[J].心血管病学进展,2021,(1):86-91.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]
　TANG Chao,CAI Lin,ZHANG Yiwen,et al.Mechanisms and Active Ingredients of Xuebiqing Injection Affecting Novel Coronavirus Infection Complicated with Myocarditis Based on Network Pharmacology[J].Advances in Cardiovascular Diseases,2021,(1):86-91.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]
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基于网络药理学的血必清注射液治疗新型冠状病毒感染合并心肌炎的作用机制研究()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年1期
页码:
86-91
栏目:
论著
出版日期:
2021-01-25

文章信息/Info

Title:
Mechanisms and Active Ingredients of Xuebiqing Injection Affecting Novel Coronavirus Infection Complicated with Myocarditis Based on Network Pharmacology
文章编号:
202003066
作者:
唐超 蔡琳 张艺文 汪汉
(西南交通大学附属医院 成都市第三人民医院心内科 成都市心血管病研究所,四川 成都 610031)
Author(s):
TANG Chao;  CAI Lin;  ZHANG Yiwen;  WANG Han
(Department of Cardiology, The Third People s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu Institute of Cardiovascular Diseases, Chengdu 610031, Sichuan, China)?/html>
关键词:
血必清注射液; 新型冠状病毒合并心肌炎; 网络药理学; 作用机制
Keywords:
Xuebiqing injection ; Novel coronavirus infection complicated with myocarditis; Network pharmacology;  Mechanism
DOI:
10.16806/j.cnki.issn.1004-3934.2021.01.000
摘要:
目的 基于网络药理学探索血必清注射液作用于 新型冠状病毒感染合并心肌炎的主要活性成分及作用机制。方法 利用TCMSP数据库对血必清注射液的主要活性成分及其靶点筛选，再运用GeneCards数据库和OMIM数据库筛选 新型冠状病毒感染合并心肌炎的相关靶点，最后对药物靶点和疾病靶点进行Venn分析得到血必清注射液作用于新型冠状病毒感染合并心肌炎的交集靶点。利用STRING数据库对交集靶点进行蛋白互作网络分析并筛选关键靶点。采用Cytoscape3.6.1软件构建“药物-活性成分-靶点-疾病”网络图，对靶点基因进行基因本体富集分析和京都基因与基因组百科全书（KEGG）通路分析。 结果 经筛选得到血必清注射液作用于新型冠状病毒感染合并心肌炎的活性成分125个和作用靶点41个，主要涉及71个生物学过程和135条通路。 结论 本研究初步验证血必清注射液可通过多成分、多靶点和多通路来发挥治疗新型冠状病毒感染合并心肌炎的作用。
Abstract:
Objective To explore the main active ingredients and mechanism s of Xuebiqing injection on novel coronavirus infection complicated with myocarditis based on network pharmacology. Methods The main active ingredients with their targets of Xuebiqing injection were screened by TCMSP database, and the targets of novel coronavirus infection complicated with myocarditis were screened by GeneCards database and OMIM database. The intersection targets of the medicine and disease were obtained by Venn analysis. We use STRING database to clarify the protein interaction network from intersection targets and screen for the key targets. The network map of “drug-active ingredient-target-disease” was constructed by Cytoscape3.6.1 software, and the target genes were analyzed by GO enrichment analysis and KEGG pathway analysis. Results We found 125 active ingredients and 41 targets related to Xuebiqing injection as treatment for noval coronavirus infection with myocarditis, which mainly involved 71 biological processes and 135 signaling pathways. Conclusion This study preliminarily verified that Xuebiqing injection can play a role in the treatment of novel coronavirus infection complicated with myocarditis through multiple active ingredients , targets and pathways.

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相似文献/References:

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　QIN Li,YANG Xiaoqian,ZHANG Yiwen,et al.Glycyrrhiza Uralenesis on Novel Coronavirus Infection Complicated with Myocarditis Based on Network Pharmacology[J].Advances in Cardiovascular Diseases,2020,(1):1215.[doi:10.16806/j.cnki.issn.1004-3934.2020.11.000]

更新日期/Last Update: 2021-03-18