[1]陈甘潇 张中和 胡丹 夏豪.发热诱发Brugada综合征的临床及心电图特征[J].心血管病学进展,2021,(1):81-85.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]
　CHEN Ganxiao,ZHANG Zhonghe,HU Dan,et al.Clinical and Electrocardiogram Characteristics of Fever-induced Brugada Syndrome[J].Advances in Cardiovascular Diseases,2021,(1):81-85.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]
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发热诱发Brugada综合征的临床及心电图特征()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年1期
页码:
81-85
栏目:
论著
出版日期:
2021-01-25

文章信息/Info

Title:
Clinical and Electrocardiogram Characteristics of Fever-induced Brugada Syndrome
文章编号:
202005151
作者:
陈甘潇 张中和 胡丹 夏豪
(武汉大学人民医院心血管内科,湖北 武汉 430000 )
Author(s):
CHEN Ganxiao;  ZHANG Zhonghe;  HU Dan;  XIA Hao
(Department of Cardiology, Renmin Hospital of Wuhan University,Wuhan 430000,Hubei,China)
关键词:
Brugada综合征; 发热; 药物激发试验; 恶性心律失常
Keywords:
Brugada syndrome; Fever; Drug challenge test; Malignant arrhythmia
DOI:
10.16806/j.cnki.issn.1004-3934.2021.01.000
摘要:
目的 探究发热诱发Brugada综合征的临床及心电图特点。 方法 选择 2000年1月—2019年1月武汉大学人民医院收治Brugada综合征患者112例，根据诱发因素将全部病例分为发热组（34例）和非发热组，比较分析两组临床特点及药物激发试验结果。结果 发热组在主要心血管事件发生率及家族史比例方面均显著大于非发热组（52.94% vs 29.49%, P=0.018；17.65% vs 3.85%, P=0.036）；药物激发试验阳性的发热组患者表现出较发热时更长的QT间期和PR间期[（371.00±43.06）ms vs （327.00±36.89）ms, P =0.015；（187.88±27.41）ms vs（156.75±9.5）ms, P=0.022]。结论 发热诱发Brugada综合征存在着相对较高的主要心血管事件风险和相关家族史比例，同一患者由发热与药物诱导的Brugada心电图也存在差异，表明发热诱发Brugada综合征具备相对独特的临床和心电图特点。
Abstract:
Objective To explore the clinical and electrocardiogram characteristics of fever-induced Brugada syndrome. Methods From January 2000 to January 2019, 112 patients with Brugada syndrome were treated in Renmin Hospital of Wuhan University, including 34 patients with fever-induced Brugada syndrome. The clinical characteristics and drug challenge test results were analyzed. According to the inducing factors,they were divided into fever-induced group and non-fever group. The clinical data of each group were compared to explore the fever-induced Brugada syndrome’s characteristics. Results The ratio of major cardiovascular events and related positive family history in patients with fever-induced Brugada syndrome were significantly higher than those in non-febrile patients(52.94% vs 29.49%,P=0.018;17.65% vs 3.85%,P=0.036). Patients in fever group who tested positive in drug challenge test,showed prolonged QT interval and PR interval than that during fever [(371.00±43.06)ms vs (327.00±36.89)ms, P=0.015;(187.88 ±27.41)ms vs (156.75±9.56)ms, P=0.022]. Conclusion Fever-induced Brugada syndrome has relatively high incidence of major cardiovascular events,and a relatively large proportion of positive family history. This study shows that fever-induced Brugada syndrome has relatively unique clinical characteristics

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更新日期/Last Update: 2021-03-18