[1]于博文 修成奎 王雪 杨静 雷燕.内皮微粒在临床中的研究进展及应用[J].心血管病学进展,2021,(1):76-80.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]
 YU Bowen,XIU Chengkui,WANG Xue,et al.Research Progress and Application of Endothelial Microparticles in Clinic[J].Advances in Cardiovascular Diseases,2021,(1):76-80.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]





Research Progress and Application of Endothelial Microparticles in Clinic
于博文12 修成奎1 王雪1 杨静1 雷燕1
(中国中医科学院医学实验中心 北京市中医药防治重大疾病基础研究重点实验室,北京 100700;2. 中国中医科学院博士后科研流动站,北京 100700)
YU Bowen12XIU Chengkui1WANG Xue1YANG Jing1LEI Yan1
Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases,Medical Experiment Center,China Academy of Chinese Medical Sciences, Beijing 100700,China; 2.Center for Post-doctoral Studies,China Academy of Chinese Medical Sciences,Beijing 100700,China)
Endothelial microparticlesEndothelial dysfunctionBiomarker Vascular health
Endothelial microparticles(EMP) are small vesicles that released from activated or damaged endothelial cells. EMP are regard as a new way of intercellular communication and play an important role in inflammatory response,coagulation response and angiogenesis. Besides,EMP are biomarkers of endothelial dysfunction and vascular health,and are closely related to a variety of diseases. However,our understanding of the molecular mechanism of EMP is not deep enough. There are limitations in clinical research, detection methods and the regulation of EMP release have brought challenges to the research of translational medicine which takes EMP as disease targets. This paper review s the research progress in the field of EMP from the concept,pathophysiological function,clinical application,detection methods and existing problems in clinical research.


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更新日期/Last Update: 2021-03-18