[1]王静娜,侯瑞田,史亦男,等.糖尿病心肌病发病机制及病理改变研究进展[J].心血管病学进展,2016,(4):412-415.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.022]
 WANG Jingna,HOU Ruitian,SHI Yinan,et al.Research Progress on Pathogenesis and Pathological Changes of Diabetic Cardiomyopathy[J].Advances in Cardiovascular Diseases,2016,(4):412-415.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.022]
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糖尿病心肌病发病机制及病理改变研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年4期
页码:
412-415
栏目:
综述
出版日期:
2016-08-15

文章信息/Info

Title:
Research Progress on Pathogenesis and Pathological Changes of Diabetic Cardiomyopathy
作者:
王静娜1侯瑞田2史亦男1王福慧1综述金凤表1审校
1.承德医学院附属医院内分泌科,河北 承德 067000; 2.承德医学院附属医院心内科,河北 承德 067000
Author(s):
WANG Jingna1 HOU Ruitian2 SHI Yinan1 WANG Fuhui1 JIN Fengbiao1
1. Department of Endocrinology, The Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei, China; 2. Department of Cardiology, The Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei, China
关键词:
糖尿病心肌病 发病机制 病理变化
Keywords:
Diabetic cardiomyopathy Pathogenesis Pathological changes
分类号:
R541.8
DOI:
10.16806/j.cnki.issn.1004-3934.2016.04.022
文献标志码:
A
摘要:
长期糖尿病可引起一种独立于高血压、冠心病等疾病的特异性心肌病变,即糖尿病心肌病。糖尿病心肌病是一种渐进性疾病,其发病机制尚未完全阐明,高血糖、高血脂、炎症及心肌舒缩功能障碍等均影响糖尿病心肌病的进展。现对近几年糖尿病心肌病的发病机制及病理改变最新研究进展综述如下。
Abstract:
Long-term diabetes can cause diabetic cardiomyopathy(DCM), a specific form of cardiomyopathy, independent hypertension, coronary heart disease and other diseases. DCM is a progressive disease and its pathogenesis has not been fully understood. Its progression is affected by high blood sugar, high cholesterol, inflammation and myocardial function disorders and many other factors. In this paper, the latest research progress of DCM is summarized as follows in recent years.

参考文献/References:

[1] Guariguata L. By the numbers:new estimates from the IDF diabetes atlas update for 2012[J]. Diabetes Res Clin Pract,2012,98(3):524-525.
[2] Pappachan JM, Varghese GI, Sriraman R, et al. Diabetic cardiomypathy:pathophysiology, diagnostic evaluation and management[J]. World J Diabetes,2013,4(5):177-189.
[3] Chavali V, Tyagi SC, Mishra PK. Predictors and prevention of diabetic cardiomyopathy[J]. Diabetes Metab Syndr Obes,2013,2013(6):151-160.
[4] Duan J, Wei G, Cui J, et al. Aralia taibiensis protects cardiac myocytes against high glucose-induced oxidative stress and apoptosis[J]. Am J Chin Med,2015,43(6):1159-1175.
[5] Winhofer Y, Krssák M, Jankovic D, et al. Short-term hyperinsulinemia and hyperglycemia increase myocardial lipid content in normal subjects[J]. Diabetes,2012,61(5):1210-1216.
[6] Calligaris SD, Lecanda M, Solis F, et al. Mice long-term high-fat diet feeding recapitulates human cardiovascular alteration:an animal model to study the early phases of diabetic[J]. PLoS One,2013,8(4):e60931.
[7] van de Weijer T,Schrauwen-Hinderling VB,Schrauwen P. Lipotoxicity in type 2 diabetic cardiomyopathy[J]. Cardiovasc Res,2011,92(1):10-18.
[8] van Herpen NA, Schrauwen-Hinderling VB. Lipid accumulation in non-adipose tissue and lipotoxicity[J]. Physiol Behav,2008,94(2):231-241.
[9] Srivastava A, Shinn AS, Lee PJ, et al.MKK3 mediates inflammatory response through modulation of mitochondrial function[J].Free Radic Biol Med,2015,83(15):139-148.
[10] Risco A, del Fresno C, Mambol A, et al. p38γ and p38δ kinases regulate the Toll-like receptor 4(TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation[J]. Proc Natl Acad Sci USA,2012,109(28):11200-11205.
[11] Guleria RS, Choudhary R, Tanaka T, et al. Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis:role of the renin-angiotensin system[J]. J Cell Physiol,2011,226(5):1292-1307.
[12] Kumar R, Yong QC, Thomas CM, et al. Intracardiac intracellular angiotensin system in diabetes[J]. Am J Physiol Regul Integr Comp Physiol,2012,302(5):R510-R517.
[13] Kurdi M, Booz GW. New take on the role of angiotensin Ⅱ in cardiac hypertrophy and fibrosis[J]. Hypertension,2011,57(6):1034-1038.
[14] Thomas CM, Yong QC, Seqqat R, et al. Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model:comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor[J]. Clin Sci,2013,124(8):529-541.
[15] Hohensinner PJ, Niessner A, Huber K, et al. Inflammation and cardiac outcome[J]. Curr Opin Infect Dis,2011,24(3):259-264.
[16] Tanaka K, Essick EE, Doros G, et al. Circulating matrix metalloproteinases and tissue inhibitors of metalloproteinases in cardiac amyloidosis[J]. J Am Heart Assoc,2013,2(2):e005868.
[17] Wauman J, Tavemier J. Leptin receptor signaling:pathways to leptin resistance[J].Front Biosci(Landmark Ed),2011,17(16):2771-2793.
[18] Vasselli JR. The role of dietary components in leptin resistance[J]. Adv Nutr,2012,3(5):736-738.
[19] Erickson JR, Pereira L, Wang L, et al. Diabetic hyperglycemia activates CaMKⅡ and arrhythmias by O-linked glycosylation[J]. Nature,2013,502(7471):372-376.
[20] Dhalla NS, Takeda N, Rodriguez-Leyya D, et al. Mechanisms of subcellular remodeling in heart falure due to diabetes[J].Heart Fail Rev,2014,19(1):87-99.
[21] Kumar S, Kain V, Sitasawad SL. High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways[J]. Biochim Biophys Acta,2012,1820(7):907-920.
[22] Liu C, Wang L, He K. Diabetic cardiomyopathy and autophagy[J]. Zhonghua Bing Li Xue Za Zhi,2015,44(2):146-149.
[23] Kubli DA, Gustafsson AB. Unbreak my heart:targeting mitochondrial autophagy in diabetic cardiomyopathy[J]. Antioxid Redox Signal,2015,22(17):1527-1544.
[24] Bariow AD, Thomas DC. Autophagy in diabetes:β-cell dysfunction, insulin resistance, and complications[J]. DNA Cell Biol,2015,34(4):252-260.
[25] Pappachan JM, Varughese GI, Sriraman R, et al. Diabetic cardiomyopathy: pathophysiology, diagnostic evaluation and management[J]. World J Diabetes,2013,4(5):177-189.
[26] Adameova A, Dhalla NS. Role of microangiopathy in diabetic cardiomyopathy[J]. Heart Fail Rev,2014,19(1):25-33.
[27] Dimitropoulos J, Tahrani AA, Stevens MJ. Cardiac autonomic neuropathy in patients with diabetes mellitus[J]. World J Diabetes,2014,5(1):17-39.
[28] Kuehl M, Stevens MJ. Cardiovascular autonomic neuropathies as complications of diabetes mellitus[J]. Nat Rev Endocrinol,2012,8(7):405-416.

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备注/Memo

备注/Memo:
作者简介:王静娜(1990—),在读硕士,主要从事内分泌与代谢性疾病研究。Email:940392589@qq.com 通信作者:金凤表(1965—),主任医师,教授,主要从事内分泌与代谢性疾病研究。Email:hrt65@sohu.com
更新日期/Last Update: 2016-07-25