[1]陈芸,综述,吕湛,等.心肌干细胞与心肌微环境研究进展[J].心血管病学进展,2016,(4):415-419.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.023]
 CHEN Yun,L Zhan.Advances in Association Between Myocardial Stem Cells and Its Microenvironment[J].Advances in Cardiovascular Diseases,2016,(4):415-419.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.023]
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心肌干细胞与心肌微环境研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年4期
页码:
415-419
栏目:
综述
出版日期:
2016-08-15

文章信息/Info

Title:
Advances in Association Between Myocardial Stem Cells and Its Microenvironment
作者:
陈芸1综述吕湛12审校
1.川北医学院,四川 南充 637000; 2.川北医学院附属医院心内科,四川 南充 637000
Author(s):
CHEN Yun1LÜ Zhan12
1. North Sichuan Medical College,Nanchong 637000,Sichuan,China; 2. Department of Cardiology,The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China
关键词:
心肌修复 心肌干细胞 微环境 调控
Keywords:
Myocardial rebuilding Myocardial stem cells Microenvironment Regulation
分类号:
R457.7
DOI:
10.16806/j.cnki.issn.1004-3934.2016.04.023
文献标志码:
A
摘要:
心肌梗死等心脏疾病会造成心脏相应部位的心肌细胞损伤坏死,随后出现瘢痕、心室重塑、心脏增大,最终导致心力衰竭,从而威胁患者的生命。目前主要的治疗手段是通过药物治疗、支架植入、外科手术、器官移植,但这些方法都存在各自的缺陷,寻求更优的治疗手段成为现今的一个热点。以前认为心肌细胞不可再生,不能自我更新、修复,但越来越多的研究显示心脏中存在心肌干细胞。许多学者通过研究发现干细胞移植能够修复坏死的心肌,为心脏的再生提供可能,心肌干细胞的发现为心脏疾病的治疗提供了一个广阔的前景。干细胞的增殖与分化受心肌组织中微环境的调控,但心肌梗死后会造成梗死区心肌组织的微环境发生改变如内分泌因子、渗透压、pH值等,从而影响干细胞的迁移、存活、定向分化。移植后的心肌干细胞能否向心肌坏死区域迁移,并且存活,然后定向分化为心肌细胞受许多因素影响,主要就心肌组织中微环境对心肌干细胞的调控进行相关阐述。
Abstract:
Myocardial cells damaged by myocardial infarction, may lead to ventricular scar and remodeling,and these changes ultimately lead to heart failure thereby threatening the lives of patients.Many research have focused on sufficient methods and treatment options for this disease, because traditional therapeutic program such as medication,surgery,stent implants and even organ transplantation have their shortcomings and can not provide sufficient protection. An increasing number of studies find that stem cells located in myocardial tissue are different to myocardial cells and are capable of renovating the damaged myocardial cells,a concept previously thought to be impossible. Although the findings of stem cell research provides a broad prospect for the treatment of various heart disease,there are many factors that can affect the stem cell transfer to infarcted areas and whether it can be differentiated into functional myocardial cells. In this review, the regulation of myocardial microenvironment and cytokines on myocardial stem cell will be discussed.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:陈芸(1991—),在读硕士,主要从事高血压及冠心病研究。Email:1017414211@qq.com 通信作者:吕湛(1967—),主任医师,主要从事高血压及冠心病研究。Email:Doctor_LZ@163.com
更新日期/Last Update: 2016-07-25