[1]范贵娟,综述,徐瑞,等.盐敏感性高血压的研究进展[J].心血管病学进展,2016,(4):364-368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.010]
 FAN Guijuan,XU Rui.Research Progress of Salt Sensitive Hypertension[J].Advances in Cardiovascular Diseases,2016,(4):364-368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.010]
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盐敏感性高血压的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年4期
页码:
364-368
栏目:
综述
出版日期:
2016-08-15

文章信息/Info

Title:
Research Progress of Salt Sensitive Hypertension
作者:
范贵娟12综述徐瑞1审校
1.山东大学附属千佛山医院心血管内二科,山东 济南 250014; 2.山东中医药大学第二临床医学院,山东 济南 250014
Author(s):
FAN Guijuan12 XU Rui1
1. Department of Cardiology, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014,Shandong, China; 2. Shandong University of Traditional Chinese Medicine, Jinan 250014,Shandong, China
关键词:
高血压 盐敏感 发病机制 基因研究 治疗靶点
Keywords:
High blood pressure Salt sensitivity Pathogenesis Gene research Therapeutic targets
分类号:
R544.1
DOI:
10.16806/j.cnki.issn.1004-3934.2016.04.010
文献标志码:
A
摘要:
盐敏感性高血压是中国人群高血压的常见类型,其血压控制不满意,并发症严重,导致人们对盐敏感性高血压关注度越来越高。为了指导盐敏感性高血压的诊治,延缓靶器官损害,研究人员围绕其发生机制进行了大量研究,并且发现了新的治疗靶点。现对盐敏感性高血压的发病机制、基因研究及新的治疗靶点进行综述。
Abstract:
Salt sensitive hypertension is a common type of hypertension in China. Salt sensitive hypertension is characterized by difficult to control blood pressure and more serious complications, which leads people to concentrate increasingly on salt sensitivity of high blood pressure. In order to guide the diagnosis and treatment of high blood pressure, and delay target-organ damage, researchers have researched to understand how salt sensitivity develops in humans, and found new therapeutic targets. In this review we will summarize pathogenesis, gene research and therapeutic targets of salt sensitive hypertension.

参考文献/References:

[1] Jablonski KL, Racine ML, Geolfos CJ, et al. Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure[J]. J Am Coll Cardiol,2013,61(3):335-343.
[2] 宁少雄, 尚志星, 邵珊, 等. Rac1 抑制剂对盐敏感性高血压肾损害大鼠转化生长因子β-1及Ⅲ型胶原表达的影响[J]. 中华高血压杂志,2015,23(4): 349-353.
[3] Oberleithner H, Peters W, Kusche-Vihrog K, et al. Salt overload damages the glycocalyx sodium barrier of vascular endothelium[J]. Pflügers Arch,2011,462(4):519-528.
[4] Briet M, Schiffrin EL. The role of aldosterone in the metabolic syndrome[J]. Curr Hypertens Rep,2011,13(2):163-172.
[5] Shibata S, Mu S, Kawarazaki H, et al. Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway[J]. J Clin Invest,2011,121(8):3233-3243.
[6] Zhou MS, Schulman IH, Pagano PJ, et al. Reduced NAD(P)H oxidase in low renin hypertension link among angiotensin Ⅱ, atherogenesis, and blood pressure[J]. Hypertension,2006,47(1):81-86.
[7] Yamauchi K, Tsuchimochi H, Stone AJ, et al. Increased dietary salt intake enhances the exercise pressor reflex[J]. Am J Physiol Heart Circ Physiol,2014,306(3):H450-H454.
[8] Ando K, Fujita T. Pathophysiology of salt sensitivity hypertension[J]. Ann Med, 2012,44(sup1):S119-S126.
[9] Zhu H, Pollock NK, Kotak I, et al. Dietary sodium, adiposity, and inflammation in healthy adolescents[J]. Pediatrics,2014,133(3):e635-e642.
[10] 高峰, 刘哲, 周静, 等. 盐敏感性高血压患者胰岛素抵抗性及其与炎症因子的关系[J]. 延安大学学报: 医学科学版,2011,9(4):12-14.
[11] Boden G, Cheung P, Kresge K, et al. Insulin resistance is associated with diminished endoplasmic reticulum stress responses in adipose tissue of healthy and diabetic subjects[J]. Diabetes,2014,63(9):2977-2983.
[12] Arcaro G, Cretti A, Balzano S, et al. Insulin causes endothelial dysfunction in humans sites and mechanisms[J]. Circulation,2002,105(5):576-582.
[13] Osborn JW, Olson DM, Guzman P, et al. The neurogenic phase of angiotensin II-salt hypertension is prevented by chronic intracerebroventricular administration of benzamil[J]. Physiol Rep,2014,2(2):e00245.
[14] 刘雪梅, 王利华, 赵风. Th17 细胞对盐敏感性高血压大鼠肾损害影响的实验研究[J]. 中国医疗前沿,2012,7(12):4-5.
[15] Worou ME, Liao TD, D'Ambrosio M, et al. Renal protective effect of N-acetyl-seryl-aspartyl-lysyl-proline in Dahl salt-sensitive rats[J]. Hypertension,2015,66(4):816-822.
[16] Grigorova YN, Juhasz O, Zernetkina V, et al. Aortic fibrosis, induced by high salt intake in the absence of hypertensive response, is reduced by a monoclonal antibody to marinobufagenin[J]. Am J Hypertens,2016,29(5):641-646.
[17] Zheng WL, Wang J, Mu JJ, et al. Effects of salt intake and potassium supplementation on renalase expression in the kidneys of Dahl salt-sensitive rats[J]. Exp Biol Med,2016,241(4):382-386.
[18] Shibata S, Zhang J, Puthumana J, et al. Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4[J]. Proc Natl Acad Sci U S A,2013,110(19):7838-7843.
[19] 汪洋, 牟建军, 刘富强, 等. 高盐喂食对 Dahl 盐敏感大鼠肾小管上皮向间质转化和肾脏纤维化的影响[J]. 中华高血压杂志,2015,3:14.
[20] Qi J, Yu XJ, Shi XL, et al. NF-κB blockade in hypothalamic paraventricular nucleus inhibits high-salt-induced hypertension through NLRP3 and caspase-1[J]. Cardiovasc Toxicol,2015,1-10[Epub ahead of print].
[21] Washburn LK, Brosnihan KB, Chappell MC, et al. The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia[J]. JRAAS,2015,16(3):912-917.
[22] Williams JS, Chamarthi B, Goodarzi MO, et al. Lysine-specific demethylase 1:an epigenetic regulator of salt-sensitive hypertension[J]. Am J Hypertens,2012,25(7):812-817.
[23] Zhang D, Yu Z, Cruz P, et al. Epigenetics and the control of epithelial sodium channel expression in collecting duct[J]. Kidney Int,2009,75(3):260-267.
[24] Kitamura K, Tomita K. Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension[J]. Clin Exp Nephrol,2012,16(1):44-48.
[25] Leibowitz A, Volkov A, Voloshin K, et al. Melatonin prevents kidney injury in a high salt diet-induced hypertension model by decreasing oxidative stress[J]. J Pineal Res,2016,60(1):48-54.
[26] Arai K, Tsuruoka H, Homma T. CS-3150, a novel non-steroidal mineralocorticoid receptor antagonist, prevents hypertension and cardiorenal injury in Dahl salt-sensitive hypertensive rats[J]. Eur J Pharmacol,2015,769:266-273.
[27] Toyoda S, Inami S, Kato T, et al. Choice of antihypertensive combination therapy based on daily salt intake[J]. Am J Med Sci,2015,350(3):160-166.

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备注/Memo

备注/Memo:
基金项目:山东省优秀中青年科学家科研奖励基金(BS2010YY062); 山东省医药卫生科技发展计划(2013WS0130); 山东省卫生厅青年科技基金项目(2014GSF118055) 作者简介:范贵娟(1986—),在读硕士,主要从事心血管病学研究。Email:917072500@qq.com 通信作者:徐瑞(1971—),主任医师,博士后,主要从事心血管病学研究。Email:xuruicn@hotmail.com
更新日期/Last Update: 2016-07-25